Thomas E Barnett

US Patent:

20030224390, Dec 4, 2003

Filed:

Jan 17, 2003

Appl. No.:

10/346162

Inventors:

Dana Fowlkes - Chapel Hill NC, US
Thomas Barnett - Chapel Hill NC, US
Benjamin Buehrer - Chapel Hill NC, US

Assignee:

Karo Bio AB - Huddinge

International Classification:

C12Q001/68

US Classification:

435/006000

Abstract:

Peptides which bind a cellular (surface or intracellular) receptor, such as a nuclear receptor, may be identified by screening a combinatorial peptide library presented in the form of cells each of which coexpress one member peptide and the receptor, together with a signal producing system for reporting binding. A “two-hybrid” assay is of particular interest. The screen may be carried out in the presence of a ligand, in particular, an exogenous ligand. If this screening is carried out for a plurality of different receptor conformations, then this library screening will also serve to identify conformation-specific peptides for the receptor, which may then be used in a panel for “fingerprinting” query compounds as to their ability to interact with the receptor in the presence of each of the panel peptides. These fingerprints may be compared to those of reference compounds with known biological activities mediated by that receptor.

US Patent:

20120289468, Nov 15, 2012

Filed:

Nov 12, 2010

Appl. No.:

13/509309

Inventors:

Thomas Barnett - Research Triangle Park NC, US

Assignee:

GRIFOLS THERAPEUTICS INC. - Research Triangle Park NC

International Classification:

A61K 38/37
C12N 5/10
C12N 1/21
C12N 1/15
C12N 1/19
A61P 7/00
C07K 14/00
C07K 14/755
C07K 16/00
C07H 21/04
A61P 7/02
C12P 21/00
C12N 15/63

US Classification:

514 141, 435 696, 435325, 435348, 435352, 435354, 435358, 435365, 435366, 435367, 4352523, 43525231, 43525233, 43525234, 43525235, 43525411, 4352542, 43525421, 43525423, 4353201, 530350, 530383, 5303871, 536 231

Abstract:

The present invention relates to methods, compositions and kits for preparing FVIII and employing same. Also provided are vWF polypeptides and nucleic acid molecules encoding same.

US Patent:

20230077855, Mar 16, 2023

Filed:

Aug 17, 2022

Appl. No.:

17/889875

Inventors:

Thomas Barnett - Chapel Hill NC, US
David A. Ross - Cary NC, US

Assignee:

GRIFOLS WORLDWIDE OPERATIONS LIMITED - Dublin

International Classification:

A61K 39/40
C07K 16/00
A01K 67/027
C07K 16/12

Abstract:

Embodiments of the present invention provide methods for the treatment or prevention of infection-related immune conditions using compositions comprising IgM.