Thomas D Bayne

Deceased

from Lake Havasu City, AZ

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Spore-Based Probiotic Composition For Reduction Of Dietary Endotoxemia And Related Methods
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US Patent:

20230049876, Feb 16, 2023
Filed:

Oct 18, 2022
Appl. No.:

17/968161
Inventors:

- Bagsvaerd, DK
Dale Kriz - Phoenix AZ, US
Thomas Bayne - Glenview IL, US
Assignee:

Novozymes A/S - Bagsvaerd
International Classification:

A61K 35/742
A61K 35/744
A61P 31/04
A61K 35/747
A23L 31/10
A23L 33/135
A61K 35/745
A23L 33/14
Abstract:

A method of treating metabolic endotoxemia comprising identifying a subject having post-prandial dietary endotoxemia and administering an effective amount of a spore-based probiotic. While any spore-based probiotic may be used, the probiotic supplement may comprise (HU36), (HU58), , and . One or more of a level of blood endotoxin, triglyceride, post-prandial insulin, post-prandial ghrelin level, MCP-1, GM-CSF, IL-12p70, IL-13, IL-1beta, IL-4, IL-5, IL-6, IL-7, IL-8, and TNF-α is observed as being lower after spore-based probiotic supplementation when compared to placebo. At least one of post-prandial leptin and IL-10 is observed as being higher after spore-based probiotic supplementation when compared to placebo.

Spore-Based Probiotic Composition For Reduction Of Dietary Endotoxemia And Related Methods
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US Patent:

20180289752, Oct 11, 2018
Filed:

Apr 6, 2018
Appl. No.:

15/947521
Inventors:

- Glenview IL, US
Dale Kriz - Phoenix AZ, US
Thomas Bayne - Glenview IL, US
International Classification:

A61K 35/742
A23L 31/10
A23L 33/135
A23L 33/14
A61K 35/747
A61P 31/04
Abstract:

A method of treating metabolic endotoxemia comprising identifying a subject having post-prandial dietary endotoxemia and administering an effective amount of a spore-based probiotic. While any spore-based probiotic may be used, the probiotic supplement may comprise (HU36), (HU58), , and . One or more of a level of blood endotoxin, triglyceride, post-prandial insulin, post-prandial ghrelin level, MCP-1, GM-CSF, IL-12p70, IL-13, IL-1beta, IL-4, IL-5, IL-6, IL-7, IL-8, and TNF-α is observed as being lower after spore-based probiotic supplementation when compared to placebo. At least one of post-prandial leptin and IL-10 is observed as being higher after spore-based probiotic supplementation when compared to placebo.