Thomas F Brewer

US Patent:

6423344, Jul 23, 2002

Filed:

Feb 4, 2000

Appl. No.:

09/498397

Inventors:

Robert M. Platz - Half Moon Bay CA
Thomas K. Brewer - Walnut Creek CA
Terence D. Boardman - Palo Alto CA

Assignee:

Inhale Therapeutic Systems - San Carlos CA

International Classification:

A61K 916

US Classification:

424491, 424489, 424497, 424499, 514 2, 514 3, 264 5, 264 12

Abstract:

A process for preparing ultrafine powders of biological macromolecules comprises atomizing liquid solutions of the macromolecules, drying the droplets formed in the atomization step, and collecting the particles which result from drying. By properly controlling each of the atomization, drying, and collection steps, ultrafine dry powder compositions having characteristics particularly suitable for pulmonary delivery for therapeutic and other purposes may be prepared.

US Patent:

8173168, May 8, 2012

Filed:

Sep 28, 2006

Appl. No.:

11/536348

Inventors:

Robert M. Platz - Half Moon Bay CA, US
Thomas K. Brewer - Walnut Creek CA, US
Terence D. Boardman - Palo Alto CA, US

Assignee:

Novartis Pharma AG - Basel

International Classification:

A61K 9/14
A61K 9/16

US Classification:

424489, 424499

Abstract:

A process for preparing ultrafine powders of biological macromolecules comprises atomizing liquid solutions of the macromolecules, drying the droplets formed in the atomization step, and collecting the particles which result from drying. By properly controlling each of the atomization, drying, and collection steps, ultrafine dry powder compositions having characteristics particularly suitable for pulmonary delivery for therapeutic and other purposes may be prepared.

US Patent:

20020122827, Sep 5, 2002

Filed:

Nov 9, 2001

Appl. No.:

10/007868

Inventors:

Robert Platz - Half Moon Bay CA, US
Thomas Brewer - Walnut Creek CA, US
Terrence Boardman - Palo Alto CA, US

International Classification:

A61K009/14
A61K009/50

US Classification:

424/489000, 424/499000

Abstract:

A process for preparing ultrafine powders of biological macromolecules comprises atomizing liquid solutions of the macromolecules, drying the droplets formed in the atomization step, and collecting the particles which result from drying. By properly controlling each of the atomization, drying, and collection steps, ultrafine dry powder compositions having characteristics particularly suitable for pulmonary delivery for therapeutic and other purposes may be prepared.

US Patent:

60512563, Apr 18, 2000

Filed:

May 8, 1996

Appl. No.:

8/644681

Inventors:

Robert M. Platz - Half Moon Bay CA
Thomas K. Brewer - Walnut Creek CA
Terence D. Boardman - Palo Alto CA

Assignee:

Inhale Therapeutic Systems - San Carlos CA

International Classification:

A61K 914
A61K 3800

US Classification:

424489

Abstract:

A process for preparing ultrafine powders of biological macromolecules comprises atomizing liquid solutions of the macromolecules, drying the droplets formed in the atomization step, and collecting the particles which result from drying. By properly controlling each of the atomization, drying, and collection steps, ultrafine dry powder compositions having characteristics particularly suitable for pulmonary delivery for therapeutic and other purposes may be prepared.

US Patent:

20180215773, Aug 2, 2018

Filed:

Aug 18, 2016

Appl. No.:

15/747125

Inventors:

- Oakland CA, US
Thomas Francis Brewer - Berkeley CA, US
Jefferson Chan - Urbana IL, US

International Classification:

C07F 7/08
C09K 11/06
C12Q 1/26
G01N 21/76

Abstract:

Probes for formaldehyde (FA) including a homoallylamine trigger group attached to a detectable moiety are provided. Aspects of the probes include luminogenic or fluorogenic probes, such as a probe including a quencher in energy-receiving proximity to a fluroophore. Also provided are methods of using the probes for sensitive and bio orthogonal detection of FA in a sample. Aspects of the methods include selectively reacting the probe with the formaldehyde in the sample to a release (e.g., via a 2-aza-Cope rearrangement) a reporter group comprising a detectable moiety. Aspects of the methods detecting formaldehyde in a cell, tissue, organ or fluid in a subject. Also provided are compositions and kits including the subject probes that find use in practicing various embodiments of the subject methods.