Thomas J Carr

US Patent:

6713502, Mar 30, 2004

Filed:

Nov 5, 2002

Appl. No.:

10/275426

Inventors:

Dashyant Dhanak - King of Prussia PA
Thomas Carr - Collegeville PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

A61K 3140

US Classification:

514422, 514423, 548527, 548533

Abstract:

Novel anti-infective and methods of using them are provided.

US Patent:

57338825, Mar 31, 1998

Filed:

Feb 28, 1995

Appl. No.:

8/396356

Inventors:

Thomas Joseph Carr - Phoenixville PA
Peter Lawrence DeMarsh - Downingtown PA
Geoffrey Bainbridge Dreyer - Malvern PA
Ashley Edward Fenwick - Radnor PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07D23364
A61K 31415

US Classification:

514 19

Abstract:

The present invention provides compounds, more particularly dipeptide analogs, which bind to retroviral proteases. These compounds are inhibitors of retroviral proteases and are useful for treating diseases related to infection by retroviruses.

US Patent:

40880370, May 9, 1978

Filed:

Jul 29, 1976

Appl. No.:

5/709702

Inventors:

Thomas M. Carr - Ardmore PA

International Classification:

F16H 308

US Classification:

74371

Abstract:

An improved transmission shift mechanism which incorporates both a combined synchronizing clutch and a positive engagement system for coupling and decoupling gear elements within a transmission frame. The synchronizing clutch mechanism has a plurality of circumferentially spaced latch members which are radially displaceable for frictional circumferential engagement with the inner walls of a gear member having a central bore opening. The positive engagement system is a locking unit which includes circumferentially spaced spherical elements which are also radially reciprocal for seating within corresponding recesses within the bore of the gears. The frictional engagement members and the positive locking ball elements are cooperatively actuated through contoured cam surface elements which are longitudinally displaceable within the sliding member responsive to manual operation of an extension rod in the longitudinal direction.

US Patent:

63315424, Dec 18, 2001

Filed:

Apr 19, 2000

Appl. No.:

9/551968

Inventors:

Thomas Joseph Carr - Phoenixville PA
Renee Louise Desjarlais - St. Davids PA
Timothy Francis Gallagher - Harleysville PA
Stacie Marie Halbert - Harleysville PA
Hye-Ja Oh - Exton PA
Scott Kevin Thompson - Phoenixville PA
Daniel Frank Veber - Ambler PA
Dennis Shinji Yamashita - King of Prussia PA
Jack Hwekwo Yen - Malvern PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

A61K 315375
A61K 314409
C07D40112
C07D26530

US Classification:

5142378

Abstract:

The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.

US Patent:

62323423, May 15, 2001

Filed:

Jun 11, 1999

Appl. No.:

9/330451

Inventors:

Thomas Joseph Carr - Phoenixville PA
Renee Louise Desjarlais - St. Davids PA
Timothy Francis Gallagher - Harleysville PA
Stacie Marie Halbert - Harleysville PA
Hye-Ja Oh - Exton PA
Scott Kevin Thompson - Phoenixville PA
Daniel Frank Veber - Ambler PA
Dennis Shinji Yamashita - King of Prussia PA
Jack Hwekwo Yen - Malvern PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

A61K 31277
A61K 3118
C07C25550
C07C31118

US Classification:

514524

Abstract:

The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease, hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting and bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.