Thomas Li Chen

US Patent:

7770140, Aug 3, 2010

Filed:

Feb 5, 2008

Appl. No.:

12/026141

Inventors:

Robert H. Bell - Austin TX, US
Thomas W. Chen - Austin TX, US
Venkat R. Indukuru - Austin TX, US
Pattabi M. Seshadri - Austin TX, US
Madhavi G. Valluri - Leander TX, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06F 17/50

US Classification:

716 4, 716 1

Abstract:

A test system or simulator includes an IC test application sampling software program that executes test application software on a semiconductor die IC design model. The test application sampling software includes trace, simulation point, CPI error, clustering and other programs. IC designers utilize the test application sampling software to evaluate the performance characteristics of IC designs with test software applications. The test application sampling software generates basic block vectors (BBVs) and fly-by vectors (FBVs) from instruction trace analysis of test application software. The test application sampling software analyzes microarchitecture dependent information that it uses to generate the FBVs. Test application sampling software generates a reduced representative test application software program from the BBV and FBV data utilizing an instruction budgeting method. Designers use the test system with test application sampling software to evaluate IC design models by using the representative test application software program.

US Patent:

7844928, Nov 30, 2010

Filed:

Jan 11, 2008

Appl. No.:

11/972747

Inventors:

Robert H. Bell - Austin TX, US
Thomas W. Chen - Austin TX, US
Richard J. Eickemeyer - Rochester MI, US
Venkat R. Indukuru - Austin TX, US
Pattabi M. Seshadri - Austin TX, US
Madhavi G. Valluri - Leander TX, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06F 17/50

US Classification:

716 4, 716 1

Abstract:

A test system or simulator includes an IC benchmark software program that executes application software on a semiconductor die IC design model. The benchmark software includes trace, simulation point, clustering and other programs. IC designers utilize the benchmark software to evaluate the performance characteristics of IC designs with customer user software applications. The benchmark software generates basic block vectors BBVs from instruction traces of application software. The benchmark software analyzes data dependent information that it appends to BBVs to create enhanced BBVs or EBBVs. The benchmark software may graph the EBBV information in a cluster diagram and selects a subset of EBBVs as a representative sample for each program phase. Benchmarking software generates a reduced application software program from the representative EBBV samples. Designers use the test system with benchmarking software to evaluate IC design model modifications by using the representative reduced application software program.

US Patent:

7981917, Jul 19, 2011

Filed:

Mar 26, 2008

Appl. No.:

12/056192

Inventors:

Axel H. Schönthal - Los Angeles CA, US
Nicos A. Petasis - Hacienda Heights CA, US
Florence M. Hofman - Venice CA, US
Stan G. Louie - Fullerton CA, US
Thomas C. Chen - La Canada CA, US

Assignee:

University of Southern California - Los Angeles CA

International Classification:

A61K 31/415

US Classification:

514406, 514256

Abstract:

The present invention provides a method for inducing apoptosis in selected cells by aggravating ER-stress. The aggravation of ER-stress is achieved in a specific manner by inhibiting SERCA (sarcoplasmic/endoplasmic reticulum calcium ATPase), leading to elevated level of cytoplasmic calcium concentration, yet without inhibiting the activity of COX-2 (cyclooxygenase-2) or triggering the release of histamine. Induction of apoptosis may be enhanced by first inducing or further aggravating ER-stress through inhibition of proteasome or proteases. Also provided are compounds and compositions useful as ER-stress aggravating agents, methods for screening, selecting, identifying and designing the same and methods for treating diseased conditions by inducing apoptosis through specific and selective aggravation of ER-stress.

US Patent:

8236862, Aug 7, 2012

Filed:

Feb 4, 2010

Appl. No.:

12/700614

Inventors:

Thomas C. Chen - Los Angeles CA, US
Clovis O. da Fonseca - Rio de Janeiro, BR
Thereza Quirico dos Santos - Niterói, BR
Gilberto Schwartsmann - Porto Alegre, BR

Assignee:

University of Southern California - Los Angeles CA

International Classification:

A61K 31/045

US Classification:

514729, 514724, 554229

Abstract:

This invention provides a compositions for transport of a therapeutic agent. The compositions contain a therapeutic agent and a monoterpene or an analog thereof. In one aspect, the monoterpene is perillyl alcohol (POH) or an analog thereof. In one aspect, the therapeutic agent is provided in an amount effective to treat the disease or subject of choice.

US Patent:

8507734, Aug 13, 2013

Filed:

Mar 3, 2011

Appl. No.:

13/040059

Inventors:

Thomas Chen - La Canada CA, US
Daniel Levin - La Canada CA, US
Satish Puppali - Glendora CA, US

Assignee:

Neonc Technologies Inc. - Inglewood CA

International Classification:

C07C 27/26

US Classification:

568854, 568875, 556437

Abstract:

The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98. 5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98. 5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

US Patent:

20030204560, Oct 30, 2003

Filed:

Apr 26, 2002

Appl. No.:

10/133030

Inventors:

Thomas Chen - Houston TX, US
Jenny Chen - Houston TX, US

International Classification:

G06F015/16

US Classification:

709/203000

Abstract:

A System Apparatus of Programmable Logic Controller (PLC) containing System Software of Embedded Intelligent Web Server uses a service-based application method to administrate and manage of control and system related services for controlling machines, equipment and manufacturing processes globally. The main component of System Apparatus of Programmable Logic Controller is Central Processing Unit which is connected to an Apparatus Memory , a Wireline Connection Port , a Wireless Transceiver Port , a plurality of Input Interface Module , and a plurality of Output Interface Module . Input Interface Module is connected to a plurality of Field Input Device , and Output Interface Module is connected to a plurality of Field Output Device . System Apparatus of Programmable Logic Controller is also connected by a Power Supply for power source. System Software of Embedded Intelligent Web Server resides in Central Processing Unit and is comprised of a Real-time Operation System (RTOS) , a Runtime Language Executor , a Service Central Controller . Service Central Controller is comprised of a Service Administrator , a Service Shared Memory , a plurality of Grouped and Prioritized Input Service , a plurality of Grouped and Prioritized Output Service , a plurality of Intelligent Agent Monitoring Service , a HTTP Service , a Wireline Data Service , a Wireless Data Service , and a Store and Forward Message Service . Service Central Controller is responsible for registering, installing, activating, deactivating, and uninstalling all control and system related services of PLC operations dynamically at runtime. Each control or system service, although executed independently, can be called by other services for accomplishing complex or collaborating tasks.

US Patent:

20040130446, Jul 8, 2004

Filed:

Jan 6, 2003

Appl. No.:

10/337096

Inventors:

Thomas Chen - Houston TX, US
Connie Chen - Houston TX, US

International Classification:

G08B001/08

US Classification:

340/539120, 340/539130, 340/573100

Abstract:

A Wireless Communication and Global Location Enabled Intelligent Health Monitoring System comprising of a plurality of Wireless Medical Sensor Apparatus for measuring a patient's vital signs on different parts of a patient's body, and a Main Processing Unit Apparatus containing System Software that uses an active, real-time monitoring method to process a patient's vital signs and location information for providing an alert on location and transmitting an emergency request to a remote patient monitoring station for immediate assistance. The key component of Main Processing Unit Apparatus is Main Microcontroller which is connected to Global Position System Module , Long-Range Two Way Wireless Communication Module , Short-Range RF Receiver , System Main Memory , Flash Memory , Panic Button , On/Off Button , Alert Beeper and Removable/Rechargeable Battery . Main Microcontroller comprises System Processor , Digital Signal Processing (DSP) Processor and System Interface Processor . Both Global Position System Module and Long-Range Two-Way Wireless Communication Module are connected to Multi-Band Antenna , and System Interface Processor , and means for conducting two-way wireless communication and GPS data acquisition simultaneously. Short-Range RF Receiver is connected to DSP Processor , and means for receiving wireless signal from a plurality of Wireless Medical Sensor . Wireless Medical Sensor comprises the circuitry for both vital sign measurements and short-range RF transmission, and means for measuring and interpreting a patient's vital signs, modulating and transmitting wireless signal back to Short-Range RF Receiver through a short-range RF network. System Software of the Wireless Communication and Global Location Enabled Intelligent Health Monitoring System resides in System Processor and includes Intelligent Controller , which comprises Task Control Administrator , and a plurality of Task Shared Memory . Task Control Administrator manages and controls the execution of Two-Way Wireless Communication Task , Global Position Data Acquisition Task , Panic Button Task , HTTP Request Processing Task , Patient Vital Sign Processing Task , Adaptive Location Assessment Task , On/Off Button Task , Alert Beeper Activation Task , Battery Management Task , and Wireless Medical Sensor Decoding Task . All application tasks of System Software are running under separate parallel execution threads. Under an urgent situation, the two-way wireless communication, global position data and adaptive location assessment capabilities allow an Emergency Service Vehicle to be dispatched to the patient that carries the system. The system also includes a HTTP Web server that can respond to a remote request sent wirelessly either from a patient monitoring station or a patient's family member through a standard Internet browser, anywhere and anytime. The system uses a rechargeable/removable battery in conjunction with a software control to recharge the system and conserve system's power consumption.

US Patent:

20060267731, Nov 30, 2006

Filed:

May 31, 2005

Appl. No.:

11/141762

Inventors:

Thomas Chen - Houston TX, US

International Classification:

H04Q 5/22

US Classification:

340010100, 340572100, 340539220

Abstract:

An Internet-linked RFID Sensor Network (iRfidSensorNet) system that uses sensors, RFID tags, RFID readers, intelligent-agent-based software, wireless and landline communication networks, and Internet, Intranet, Extranet links for continually identifying, sensing, monitoring, tracking and networking of multiple clusters of objects that are either at stationary location or on the move, and communicating autonomously among these object clusters within the iRfidSensorNet's accessible range. The iRfidSensorNet system comprises a plurality of Wireless RFID/Sensor Tag Apparatus for identifying, sensing and measuring object conditions, and a RFID Reader Apparatus containing System Software that uses an active, real-time concurrent method to process object's conditions and location information for providing an alert to be transmitted to a remote monitoring station for immediate attention.