Thomas M Chen

US Patent:

7799012, Sep 21, 2010

Filed:

Jul 10, 2009

Appl. No.:

12/501012

Inventors:

Yehoshua Shachar - Santa Monica CA, US
Leslie Farkas - Ojai CA, US
Bruce Marx - Ojai CA, US
David Johnson - West Hollywood CA, US
Laszlo Farkas - Ojai CA, US
Thomas C. Chen - La Canada CA, US

Assignee:

Pharmaco-Kinesis Corporation - Inglewood CA

International Classification:

A61M 31/00

US Classification:

604508, 604506, 604507, 604509, 6048901

Abstract:

A magnetically controlled pump is implanted into the brain of a patient and delivers a plurality of medicating agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled pouch that is formed from two layers of polymer. The pouch is alternately expanded and contracting by magnetic solenoid. When contracted, a medicating agent is pushed out of the pouch through a plurality of needles. When the pouch is expanded, surrounding cerebral fluid is drawn into the space between the double walls of the pouch from which it is drawn through a catheter to an analyzer. Cerebral fluid drawn from the patient is analyzed. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.

US Patent:

7799016, Sep 21, 2010

Filed:

Jun 20, 2008

Appl. No.:

12/143720

Inventors:

Yehoshua Shachar - Santa Monica CA, US
Thomas C. Chen - La Canada CA, US
Leslie Farkas - Ojai CA, US
Bruce Marx - Ojai CA, US
David Johnson - West Hollywood CA, US
Laszlo Farkas - Ojai CA, US

Assignee:

Pharmaco-Kinesis Corporation - Inglewood CA

International Classification:

A61K 9/22

US Classification:

6048911, 6048901, 604 65, 604 66, 604 67, 604508

Abstract:

A magnetically controlled pump is implanted into the brain of a patient and delivers a plurality of medicating agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled pouch that is formed from two layers of polymer. The pouch is alternately expanded and contracting by magnetic solenoid. When contracted, a medicating agent is pushed out of the pouch through a plurality of needles. When the pouch is expanded, surrounding cerebral fluid is drawn into the space between the double walls of the pouch from which it is drawn through a catheter to an analyzer. Cerebral fluid drawn from the patient is analyzed. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.

US Patent:

8133172, Mar 13, 2012

Filed:

Dec 23, 2008

Appl. No.:

12/343436

Inventors:

Josh Shachar - Santa Monica CA, US
Thomas Chen - La Canada CA, US
Leslie Farkas - Ojai CA, US
Winston Wu - Alhambra CA, US
Kyle Zimmerman - Los Angeles CA, US
Moran Cerf - Los Angeles CA, US
Bruce Marx - Ojai CA, US
David Johnson - West Hollywood CA, US
Laszlo Farkas - Ojai CA, US

Assignee:

Pharmaco-Kinesis Corporation - Inglewood CA

International Classification:

A61B 1/32

US Classification:

600202, 600544

Abstract:

Described is a surgical system for monitoring a patient's condition during surgery. One aspect is a non-contact EEG sensor. The non-contact EEG sensor can be used to predict the onset of physiological disorders. Another aspect includes the use of a plurality of pressure sensors to determine the pressure applied by retractors on the patient, including the brain and other organs.

US Patent:

8145434, Mar 27, 2012

Filed:

Apr 10, 2009

Appl. No.:

12/422125

Inventors:

Josh Yehoshua Shachar - Santa Monica CA, US
Winston H. Wu - Alhambra CA, US
Leslie Farkas - Ojai CA, US
Thomas Chen - La Canada CA, US

Assignee:

Pharmaco-Kinesis Corporation - Inglewood CA

International Classification:

G06F 11/00

US Classification:

702 19

Abstract:

A novel architecture solid-state biosensor for label-free detection of vascular endothelial growth factor (VEGF) hybridization is presented. The new device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. The detection mechanism is based on an electrochemical binding of circulating VEGF to an immobilized VEGF aptamer; whereby binding of these two compounds modulates the threshold voltage of a novel circuit, changing the impedance (capacitance) of the circuit. This novel circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the VEGF molecules and the aptamer. An apparatus forming a fluid cell is configured so as to enable the flow for delivering VEGF samples onto the active surface of the chip. The device has an array of parallel capacitors which act as an integrated, individual counter-electrode, computational apparatus which employs the sensory output over the time domain so as to enable detection, reporting and formation of a homeostatic loop for VEGF measurements.

US Patent:

8323269, Dec 4, 2012

Filed:

Oct 19, 2009

Appl. No.:

12/581756

Inventors:

Yehoshua Shachar - Santa Monica CA, US
Thomas C. Chen - La Canada CA, US
Leslie Farkas - Ojai CA, US
Bruce Marx - Ojai CA, US
David Johnson - West Hollywood CA, US
Laszlo Farkas - Ojai CA, US

Assignee:

Pharmaco-Kinesis Corporation - Inglewood CA

International Classification:

A61K 9/22

US Classification:

6048911

Abstract:

A magnetically controlled pump is implanted into the cerebrospinal fluid of a patient and delivers a plurality of medicating agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled lumen, intratumoral catheter which will be implanted. Spinal fluid drawn from the patient is analyzed. Medication is delivered on a continuous metronomic basis into the CSF via an internalized pump. CSF is removed and analyzed for VEGF and other cytokines via spectrophotometer analysis or a lab on a chip. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.

US Patent:

8323270, Dec 4, 2012

Filed:

Oct 19, 2009

Appl. No.:

12/581770

Inventors:

Yehoshua Shachar - Santa Monica CA, US
Thomas C. Chen - La Canada CA, US
Leslie Farkas - Ojai CA, US
Bruce Marx - Ojai CA, US
David Johnson - West Hollywood CA, US
Laszlo Farkas - Ojai CA, US

Assignee:

Pharmaco-Kinesis Corporation - Inglewood CA

International Classification:

A61K 9/22

US Classification:

6048911

Abstract:

A magnetically controlled pump is implanted into the brain of a patient and delivers a plurality of medicating agents mixed with Avastin at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled pouch that is formed from two layers of polymer. The pouch is alternately expanded and contracting by magnetic solenoid. When contracted, the medicating agent Avastin is pushed out of the pouch through a plurality of needles. When the pouch is expanded, surrounding cerebral fluid is drawn into the space between the double walls of the pouch from which it is drawn through a catheter to an analyzer. In cases where a tumor resection is not performed, an intratumoral catheter will be implanted. Cerebral fluid drawn from the patient is analyzed. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.

US Patent:

8507734, Aug 13, 2013

Filed:

Mar 3, 2011

Appl. No.:

13/040059

Inventors:

Thomas Chen - La Canada CA, US
Daniel Levin - La Canada CA, US
Satish Puppali - Glendora CA, US

Assignee:

Neonc Technologies Inc. - Inglewood CA

International Classification:

C07C 27/26

US Classification:

568854, 568875, 556437

Abstract:

The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98. 5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98. 5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

US Patent:

8571805, Oct 29, 2013

Filed:

Jun 22, 2010

Appl. No.:

12/820830

Inventors:

Yehoshua Shachar - Santa Monica CA, US
Winston Wu - Alhambra CA, US
Thomas Chen - La Canada CA, US
Brett Jordan - Los Angeles CA, US
Kyle Zimmerman - Los Angeles CA, US
Herwin Chan - Los Angeles CA, US
Paladin Luboff - Santa Monica CA, US

Assignee:

Pharmaco-Kinesis Corporation - Century City CA

International Classification:

G01N 33/48

US Classification:

702 19

Abstract:

A biosensor for detection of vascular endothelial growth factor (VEGF) hybridization uses an array of parallel capacitors to detect electrochemical binding of circulating VEGF to immobilized anti-VEGF monoclonal half-antibodies (a-VEGF mhAb). Binding of a-VEGF mhAb modulates the threshold voltage of a circuit, changing the impedance of the circuit. An electrode coated with a p-Si substrate enhances the affinity between the VEGF molecules. A fluid cell delivers VEGF samples onto the active surface of the chip. An array of parallel capacitors arranged in an interdigitated pattern detects the VEGF in the fluid. The detector provides an accurately measured and quantifiable rate of change of the VEGF molecules in vivo, providing real time feedback which is used to measure response of the tumor to delivered chemotherapeutic agents and biological response modifiers (BRMs) for the purpose of determining tumor burden and efficacy of the chemotherapy as part of a homeostatic loop for chemotherapy.