Thomas P Cleveland

US Patent:

8563599, Oct 22, 2013

Filed:

Mar 3, 2009

Appl. No.:

12/921013

Inventors:

Paul W. Erhardt - Toledo OH, US
Rahul Khupse - Toledo OH, US
Jefferey G. Sarver - Toledo OH, US
Thomas E. Cleveland - New Orleans LA, US
Stephen M. Boue - New Orleans LA, US
Thomas E. Wiese - New Orleans LA, US
Matthew E. Burow - New Orleans LA, US
John A. McLachlan - New Orleans LA, US

Assignee:

The United States of America, represented by the Secretary of Agriculture - Washington DC
Xavier University of Louisiana - New Orleans LA
University of Toledo - Toledo OH

International Classification:

A61K 31/352

US Classification:

514453

Abstract:

Two distinct methods are disclosed and claimed for synthesizing glyceollin I plus glyceollin II as a mixture and as their pure forms. Stereochemical isomers and various synthetic intermediates are also synthesized and claimed for their novel compositions of matter. All compounds and their mixtures are claimed for use in formulations that are useful to treat or prevent cancer, or that have utility as selective estrogen receptor modulators, such formulations including enhanced or medical foods, dietary supplements and ethical pharmaceutical agents.