Thomas E Day

US Patent:

8410193, Apr 2, 2013

Filed:

Feb 7, 2009

Appl. No.:

12/367521

Inventors:

Thomas E. Day - Rolla MO, US

International Classification:

A61K 6/083
A61F 2/00

US Classification:

523115, 216 44, 556479

Abstract:

A method of preparing a ceramic-resin composite material for bone repair, including preparing a predetermined amount of pH controlled substantially anhydrous coupling agent by mixing a liquid silane material, alcohol and organic acid, producing particulate bioactive glass having a desired particle size of less than about 53 mesh, measuring a desired quantity of the particulate bioactive glass into a mixing vessel, heating the mixing vessel and particulate bioactive glass to about 100 degrees Celsius, mixing the heated quantity of particulate bioactive glass and spraying a predetermined amount of substantially anhydrous coupling agent into the heated quantity of particulate bioactive glass to define an admixture, mixing the admixture for sufficient time to define a quantity of substantially evenly coated particles, heating the quantity of substantially evenly coated particles for sufficient time to evolve excess solvent therefrom, and incorporating the quantity of substantially evenly coated particles into a resinous matrix to define a bone replacement medium.

US Patent:

8567162, Oct 29, 2013

Filed:

Oct 28, 2010

Appl. No.:

12/914376

Inventors:

Charanpreet S. Bagga - Basking Ridge NJ, US
Hyun W. Bae - Santa Monica CA, US
Thomas E. Day - Rolla MO, US

Assignee:

Prosidyan, Inc. - Basking Ridge NJ

International Classification:

A61F 2/28
B65B 3/00

US Classification:

53428, 53431, 53432, 53436, 206438, 249121, 249134, 249140, 249160, 264102, 264109, 264517, 264571, 623 2361, 623901

Abstract:

The present disclosure relates to a dynamic bioactive bone graft material and a method of handling the material to prepare an implant. In one embodiment, a method of preparing a dynamic bioactive bone graft implant is provided. The method includes the step of providing a porous, fibrous composition of bioactive glass fibers, wherein the fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and wherein the porosity of the matrix ranges from about 100 nanometers to about 1 millimeter. The porous, fibrous composition is introduced into a mold tray, and a shaped implant is created using the mold tray. The composition may be wetted with a fluid such as saline or a naturally occurring body fluid like blood prior to creating the shaped implant. In another embodiment, the porous, fibrous composition is provided with the mold tray as a kit.

US Patent:

20100136086, Jun 3, 2010

Filed:

May 7, 2009

Appl. No.:

12/437531

Inventors:

Thomas E. Day - Rolla MO, US
Erik M. Erbe - Berwyn PA, US

International Classification:

A61F 2/28
A61K 33/42
A61K 33/00
A61P 19/08

US Classification:

424426, 424602, 424724

Abstract:

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure and plurality of pores distributed throughout the scaffold. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material.

US Patent:

20110144763, Jun 16, 2011

Filed:

Oct 28, 2010

Appl. No.:

12/914468

Inventors:

CHARANPREET S. BAGGA - Basking Ridge NJ, US
HYUN W. BAE - Santa Monica CA, US
THOMAS E. DAY - Rolla MO, US

Assignee:

PROSIDYAN INC. - Basking Ridge NJ

International Classification:

A61F 2/28
C04B 14/22

US Classification:

623 2361, 10628734

Abstract:

The present disclosure relates to a dynamic bioactive bone graft material having an engineered porosity. In one embodiment, a bone graft material is provided having bioactive glass fibers arranged in a porous matrix that is moldable into a desired shape for implantation. The material can be substantially without additives and can include at least one nanofiber. The porous matrix may include a combination of one or more pore sizes including nanopores, macropores, mesopores, and micropores. In another embodiment, a bone graft implant is provided having a matrix comprising a plurality of overlapping and interlocking bioactive glass fibers, and having a distributed porosity based on a range of pores provided in the bioactive glass fibers. The distributed porosity can comprise a combination of macropores, mesopores, and micropores, and the matrix can be formable into a desired shape for implantation into a patient.

US Patent:

20110144764, Jun 16, 2011

Filed:

Oct 28, 2010

Appl. No.:

12/914772

Inventors:

CHARANPREET S. BAGGA - Basking Ridge NJ, US
Hyun W. Bae - Santa Monica CA, US
Thomas E. Day - Rolla MO, US

Assignee:

PROSIDYAN INC. - Basking Ridge NJ

International Classification:

A61F 2/28
A61K 9/00
A61K 33/42
A61K 33/00
A61K 33/06
A61P 19/00

US Classification:

623 2361, 424423, 424602, 424724, 424696

Abstract:

The present disclosure relates to a bone graft material and a bone graft implant formed from the material. In some embodiments, the bone graft implant comprises a porous matrix having a plurality of overlapping and interlocking bioactive glass fibers and a plurality of pores dispersed throughout the matrix, whereby the fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the pores are characterized by pore diameters ranging from about 100 nanometers to about 1 millimeter. The implant may be formed into a desired shape for a clinical application. The embodiments may be employed to treat a bone defect. For example, the bone graft material may be wetted and molded into a suitable form for implantation. The implant may then be introduced into a prepared anatomical site.

US Patent:

20230077763, Mar 16, 2023

Filed:

May 23, 2022

Appl. No.:

17/750861

Inventors:

- New Providence NJ, US
Hyun W. Bae - Los Angeles CA, US
Thomas E. Day - Rolla MO, US

International Classification:

A61L 27/42

Abstract:

The present disclosure relates to a dynamic bioactive bone graft material having an engineered porosity. In one embodiment, a bone graft material is provided having bioactive glass fibers arranged in a porous matrix that is moldable into a desired shape for implantation. The material can be substantially without additives and can include at least one nanofiber. The porous matrix may include a combination of one or more pore sizes including nanopores, macropores, mesopores, and micropores. In another embodiment, a bone graft implant is provided having a matrix comprising a plurality of overlapping and interlocking bioactive glass fibers, and having a distributed porosity based on a range of pores provided in the bioactive glass fibers. The distributed porosity can comprise a combination of macropores, mesopores, and micropores, and the matrix can be formable into a desired shape for implantation into a patient.

US Patent:

20200093963, Mar 26, 2020

Filed:

Nov 26, 2019

Appl. No.:

16/695997

Inventors:

- New Providence NJ, US
Hyun W. Bae - Los Angeles CA, US
Thomas E. Day - Rolla MO, US

International Classification:

A61L 27/42

Abstract:

The present disclosure relates to a dynamic bioactive bone graft material having an engineered porosity. In one embodiment, a bone graft material is provided having bioactive glass fibers arranged in a porous matrix that is moldable into a desired shape for implantation. The material can be substantially without additives and can include at least one nanofiber. The porous matrix may include a combination of one or more pore sizes including nanopores, macropores, mesopores, and micropores. In another embodiment, a bone graft implant is provided having a matrix comprising a plurality of overlapping and interlocking bioactive glass fibers, and having a distributed porosity based on a range of pores provided in the bioactive glass fibers. The distributed porosity can comprise a combination of macropores, mesopores, and micropores, and the matrix can be formable into a desired shape for implantation into a patient.

US Patent:

20140214173, Jul 31, 2014

Filed:

Mar 27, 2014

Appl. No.:

14/227019

Inventors:

Thomas E. Day - Rolla MO, US
Erik M. Erbe - Rancho Santa Fe CA, US
Steven B. Jung - Rolla MO, US

International Classification:

A61F 2/28

US Classification:

623 2356, 264 453

Abstract:

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.