Thomas Clinton Day

US Patent:

8410193, Apr 2, 2013

Filed:

Feb 7, 2009

Appl. No.:

12/367521

Inventors:

Thomas E. Day - Rolla MO, US

International Classification:

A61K 6/083
A61F 2/00

US Classification:

523115, 216 44, 556479

Abstract:

A method of preparing a ceramic-resin composite material for bone repair, including preparing a predetermined amount of pH controlled substantially anhydrous coupling agent by mixing a liquid silane material, alcohol and organic acid, producing particulate bioactive glass having a desired particle size of less than about 53 mesh, measuring a desired quantity of the particulate bioactive glass into a mixing vessel, heating the mixing vessel and particulate bioactive glass to about 100 degrees Celsius, mixing the heated quantity of particulate bioactive glass and spraying a predetermined amount of substantially anhydrous coupling agent into the heated quantity of particulate bioactive glass to define an admixture, mixing the admixture for sufficient time to define a quantity of substantially evenly coated particles, heating the quantity of substantially evenly coated particles for sufficient time to evolve excess solvent therefrom, and incorporating the quantity of substantially evenly coated particles into a resinous matrix to define a bone replacement medium.

US Patent:

20100136086, Jun 3, 2010

Filed:

May 7, 2009

Appl. No.:

12/437531

Inventors:

Thomas E. Day - Rolla MO, US
Erik M. Erbe - Berwyn PA, US

International Classification:

A61F 2/28
A61K 33/42
A61K 33/00
A61P 19/08

US Classification:

424426, 424602, 424724

Abstract:

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure and plurality of pores distributed throughout the scaffold. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material.

US Patent:

57169039, Feb 10, 1998

Filed:

Jan 3, 1997

Appl. No.:

8/778890

Inventors:

Richard M. Kramer - Chesterfield MO
Thomas M. Day - Creve Coeur MO
Ralph E. Lindemann - St. Louis MO
Jane L. Gillespie - University City MO

Assignee:

Monsanto Company - St. Louis MO

International Classification:

A01N 5702

US Classification:

504206

Abstract:

Solid N-phosphonomethylglycine or glyphosate acid is charged to a substantially closed system and then partially pre-dried as by continuously recirculating it through a hot air grinding/drying system. A cooled solution of ammonium hydroxide is then metered into and reacted with the partially dried glyphosate acid as it is being recirculated in a manner such that the moisture content of the reaction mass so formed is continuously decreased throughout the reaction. Following completion of the ammonium hydroxide addition, a powdered reaction mass/product having a moisture content of about 2 wt. % is formed. Significantly, at this stage, the ammonium glyphosate product is suitable for end use and it can be readily dissolved in water and immediately used as a herbicide or plant growth regulator. More importantly, however, this product is capable due to its highly sorptive character to be further formulated into a product exceptionally highly loaded with adjuvants and particularly surfactants.

US Patent:

56333978, May 27, 1997

Filed:

Jun 7, 1995

Appl. No.:

8/485316

Inventors:

Jane L. Gillespie - University City MO
Thomas M. Day - Creve Coeur MO
Richard M. Kramer - Chesterfield MO

Assignee:

Monsanto Company - St. Louis MO

International Classification:

C07F 938

US Classification:

562 17

Abstract:

Solid N-phosphonomethylglycine or glyphosate acid in "wet cake" form is charged to a suitable mixer/reactor. A stoichiometric equivalent of anhydrous ammonia gas is fed to the mixer for direct reaction with the glyphosate acid as it is agitated within the mixer. A water Jacket containing circulating water or other suitable heat transfer facilitating means readily known to those in the art is adapted to the mixer and used to remove heat from the reactor produced by the exothermic reaction. The moisture content of the glyphosate wet cake, the design of the mixer including a preferred close tolerance relation between the inner walls of the reactor and its mixing impellers together with the relative location of the ammonia gas inlet in the mixer/reactor and maintenance of a reaction temperature of about 60. degree. C. or below are all important process variables. The ammonium glyphosate thereby produced is a highly sorptive, water-soluble powder suitable for end use as a plant growth regulator or as a herbicide without further processing.

US Patent:

56144687, Mar 25, 1997

Filed:

Jun 7, 1995

Appl. No.:

8/472152

Inventors:

Richard M. Kramer - Chesterfield MO
Thomas M. Day - Creve Coeur MO
Ralph E. Lindemann - St. Louis MO
Jane L. Gillespie - University City MO

Assignee:

Monsanto Company - St. Louis MO

International Classification:

A01N 5702

US Classification:

504206

Abstract:

Solid N-phosphonomethylglycine or glyphosate acid is charged to a substantially closed system and then partially pre-dried as by continuously recirculating it through a hot air grinding/drying system. A cooled solution of ammonium hydroxide is then metered into and reacted with the partially dried glyphosate acid as it is being recirculated in a manner such that the moisture content of the reaction mass so formed is continuously decreased throughout the reaction. Following completion of the ammonium hydroxide addition, a powdered reaction mass/product having a moisture content of about 2 wt. % is formed. Significantly, at this stage, the ammonium glyphosate product is suitable for end use and it can be readily dissolved in water and immediately used as a herbicide or plant growth regulator. More importantly, however, this product is capable due to its highly sorptive character to be further formulated into a product exceptionally highly loaded with adjuvants and particularly surfactants.

US Patent:

20140214173, Jul 31, 2014

Filed:

Mar 27, 2014

Appl. No.:

14/227019

Inventors:

Thomas E. Day - Rolla MO, US
Erik M. Erbe - Rancho Santa Fe CA, US
Steven B. Jung - Rolla MO, US

International Classification:

A61F 2/28

US Classification:

623 2356, 264 453

Abstract:

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.

US Patent:

20140180434, Jun 26, 2014

Filed:

Dec 20, 2012

Appl. No.:

13/721724

Inventors:

Thomas E. Day - Rolla MO, US
Erik M. Erbe - Rancho Santa Fe CA, US
Steven B. Jung - Rolla MO, US

International Classification:

A61F 2/28

US Classification:

623 2356, 427 227

Abstract:

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.