Thomas R Doran

US Patent:

53428331, Aug 30, 1994

Filed:

Nov 22, 1993

Appl. No.:

8/155663

Inventors:

Thomas I. Doran - West Orange NJ
John A. McLane - New Haven CT
Masami Okabe - Nutley NJ
Michelangelo Scalone - Birsfelden, CH
Milan R. Uskokovic - Upper Montclair, NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07C40100

US Classification:

514167

Abstract:

The invention is drawn to compounds of the formula ##STR1## wherein R. sup. 1 and R. sup. 2 are hydrogen or acyl; provided that only one of R. sup. 1 or R. sup. 2 is hydrogen, useful in the treatment of hyperproliferative skin diseases and sebaceous gland diseases.

US Patent:

53843142, Jan 24, 1995

Filed:

Mar 11, 1994

Appl. No.:

8/212453

Inventors:

Thomas I. Doran - West Orange NJ
Milan R. Uskokovic - Upper Montclair NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07C40100

US Classification:

514167

Abstract:

This invention is for 1. alpha. -fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol, which can be further characterized by the formula: ##STR1## and which is useful as an agent for the treatment of sebaceous gland diseases such as acne and sebhorreic dermatitis.

US Patent:

53691261, Nov 29, 1994

Filed:

Jan 6, 1993

Appl. No.:

8/001144

Inventors:

Thomas I. Doran - West Orange NJ
Michael Rosenberger - Caldwell NJ
Stanley S. Shapiro - Livingston NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

A61K 3120
C07C 5900

US Classification:

514559

Abstract:

A compound of the formula ##STR1## its pharmaceutically acceptable salts, and its pharmaceutically acceptable hydrolyzable esters for reducing sebum secretion and combatting acne as well as oral and topical compositions for use thereof.

US Patent:

53939000, Feb 28, 1995

Filed:

Jun 7, 1994

Appl. No.:

8/255012

Inventors:

Thomas I. Doran - West Orange NJ
John A. McLane - New Haven CT
Masami Okabe - Nutley NJ
Michelangelo Scalone - Birsfelden, CH
Milan R. Uskokovic - Upper Montclair NJ

Assignee:

Hoffmann-La Roche inc. - Nutley NJ

International Classification:

C07J 900

US Classification:

552505

Abstract:

The invention comprises compounds of the formula ##STR1## wherein R. sup. 1 and R. sup. 2 are hydrogen or acyl; provided that only one of R. sup. 1 or R. sup. 2 is hydrogen, useful in the treatment of hyperproliferative skin diseases and sebaceous gland diseases. The invention also includes a process for making these compounds and steroid intermediates of the process.

US Patent:

39947424, Nov 30, 1976

Filed:

Nov 29, 1974

Appl. No.:

5/528106

Inventors:

David B. Russell - Westfield NJ
Thomas J. Doran - Norton OH

Assignee:

PPG Industries, Inc. - Pittsburgh PA

International Classification:

C08K 154
C08K 334
C09C 128
C08K 904

US Classification:

106288Q

Abstract:

Abrasion-resistant vulcanized rubber compositions which are also resistant to heat build-up are provided which are useful as tire treads and subtreads for vehicles, e. g. , automobiles. The compounds comprise the vulcanizate of a rubber polymer, a finely-divided reinforcing siliceous pigment, and an organic coupling agent having at least one nitrogen functional group that bonds to the siliceous pigment and at least one sulfur functional group that bonds to the rubber polymer.

US Patent:

54280290, Jun 27, 1995

Filed:

Nov 24, 1993

Appl. No.:

8/158068

Inventors:

Thomas I. Doran - West Orange NJ
Bernard M. Hennessy - Nutley NJ
John A. McLane - West Haven CT
Giacomo Pizzolato - Glen Ridge NJ
Farhad Sedarati - Wayne NJ
Milan R. Uskokovic - Upper Montclair NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07C40100

US Classification:

514167

Abstract:

Compounds of the formula ##STR1## wherein R is hydrogen, hydroxy, or fluorine, X is H. sub. 2 or. dbd. CH. sub. 2, and the 23,24-double bond is E or Z, are useful as agents for the treatment of hyperproliferative disorders of the skin such as psoriasis, as agents for the treatment of tumors such as breast cancer, as agents for the treatment of neoplastic diseases such as leukemia, and as agents for the treatment of sebaceous gland diseases such as acne and seborrheic dermatitis.

US Patent:

57474788, May 5, 1998

Filed:

Nov 23, 1994

Appl. No.:

8/344421

Inventors:

Thomas I. Doran - West Orange NJ
John Arthur McLane - New Haven CT

Assignee:

Hoffman-La Roche Inc. - Nutley NJ

International Classification:

A61K 3159

US Classification:

514167

Abstract:

Compounds of the formula ##STR1## wherein R. sup. 1 and R. sup. 2 are hydrogen or acyl; provided that only one of R. sup. 1 or R. sup. 2 is hydrogen are taught as useful in the treatment of hyperproliferative skin diseases and sebaceous gland diseases.