Thomas Stephen Everett

US Patent:

51165996, May 26, 1992

Filed:

Jul 31, 1989

Appl. No.:

7/388049

Inventors:

Walter J. Rogers - Ellicott City MD
Thomas S. Everett - Lutherville MD

Assignee:

Johns Hopkins Univ. - Baltimore MD
Towson State Univ. - Lutherville MD

International Classification:

G01N 3100
G01N 2400
C07H 100
C07H 1500

US Classification:

424 9

Abstract:

Accordingly, the present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies. The perfluoro-t-butyl (PFTB) moiety, ##STR1## is an excellent reporter group for fluorine-19 NMR/MRI. It is a source of nine magnetically equivalent fluorine nuclei which generate a single intense resonance for easy detection in spectroscopy or imaging. This signal is a sharp singlet, not split by neighboring nuclei or spread over a wide frequency range and eliminates any chance of ghost images which might arise from multiple resonances. These spectral properties ensure a maximum signal-to-noise ratio (S/N) for readily detecting this moiety. The foregoing allows either reduction in the concentration of the derivatized compound, ability to use MRI instruments with lower field strengths, a reduction in imaging times, or a combination of the foregoing as a result of this moiety producing a single, sharp, intense resonance.

US Patent:

53245040, Jun 28, 1994

Filed:

Mar 4, 1993

Appl. No.:

8/010013

Inventors:

Walter J. Roger - Ellicott City MD
Thomas S. Everett - Lutherville MD

Assignee:

The Johns Hopkins University - Baltimore MD
Towson State University - Lutherville MD

International Classification:

A61B 5055
C07C 5321
C07C21103
A61K 3120

US Classification:

424 9

Abstract:

Accordingly, the present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies. The perfluoro-t-butyl (PFTB) moiety, ##STR1## is an excellent reported group for fluorine-19 NMR/MRI. It is a source of nine magnetically equivalent fluorine nuclei which generate a single intense resonance for each detection in spectroscopy or imaging. This signal is a sharp singlet, not split by neighboring nuclei or spread over a wide frequency range and eliminates any change of ghost images which might arise from multiple resonances. These spectral properties ensure a maximum signal-to-noise ratio (S/N) for readily detecting this moiety. The foregoing allows either reduction in the concentration of the derivatized compound, ability to use MRI instruments with lower field strengths, a reduction in imaging times, or a combination of the foregoing as a result of this moiety producing a single, sharp, intense resonance. Additionally, the PFTB moiety-containing compounds may be utilized to determine oxygen concentration in aqueous solutions present in animate and inanimate objects.

US Patent:

52346803, Aug 10, 1993

Filed:

Sep 19, 1991

Appl. No.:

7/762445

Inventors:

Walter J. Rogers - Ellicott City MD
Thomas S. Everett - Lutherville MD

Assignee:

Johns Hopkins Univ. - Baltimore MD
Towson State University - Lutherville MD

International Classification:

G01N 2408
G12Q 156
A61K 3700
C07C21100

US Classification:

424 9

Abstract:

The present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies. The perfluoro-t-butyl (PFTB) moiety, ##STR1## is an excellent reporter group for fluorine-19 NMR/MRI. It is a source of nine magnetically equivalent fluorine nuclei which generate a single intense resonance for easy detection in spectroscopy or imaging. This signal is a sharp singlet, not split by neighboring nuclei or spread over a wide frequency range and eliminates any chance of ghost images which might arise from multiple resonances. These spectral properties ensure a maximum signal-to-noise ratio (S/N) for readily detecting this moiety. The foregoing allows either reduction in the concentration of the derivatized compound, ability to use MRI instruments with lower field strengths, a reduction in imaging times, or a combination of the foregoing as a result of this moiety producing a single, sharp, intense resonance. Additionally, the PFTB moiety-containing compounds may be utilized to determine oxygen concentration in aqueous solutions present in animate and inanimate objects.

US Patent:

53975634, Mar 14, 1995

Filed:

Mar 1, 1994

Appl. No.:

8/203945

Inventors:

Walter J. Rogers - Ellicott City MD
Thomas S. Everett - Lutherville MD

Assignee:

The Johns Hopkins University - Baltimore MD
Towson State University - Towson MD

International Classification:

A61B 5055
C07J 5100

US Classification:

424 9

Abstract:

Accordingly, the present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies. The perfluoro-t-butyl (PFTB) moiety, ##STR1## is an excellent reporter group for fluorine-19 NMR/MRI. It is a source of nine magnetically equivalent fluorine nuclei which generate a single intense resonance for easy detection in spectroscopy or imaging. This signal is a sharp singlet, not split by neighboring nuclei or spread over a wide frequency range and eliminates any chance of ghost images which might arise from multiple resonances. These spectral properties ensure a maximum signal-to-noise ratio (S/N) for readily detecting this moiety. The foregoing allows either reduction in the concentration of the derivatized compound, ability to use MRI instruments with lower field strengths, a reduction in imaging times, or a combination of the foregoing as a result of this moiety producing a single, sharp, intense resonance. Additionally, the PFTB moiety-containing compounds may be utilized to determine oxygen concentration in aqueous solutions present in animate and inanimate objects.