Thomas P Freeman

US Patent:

6528245, Mar 4, 2003

Filed:

May 7, 1999

Appl. No.:

09/307824

Inventors:

Juan Sanchez-Ramos - Tampa FL
Shijie Song - Tampa FL
William Janssen - Tampa FL
Paul Sanberg - Spring Hill FL
Thomas Freeman - Tampa FL

Assignee:

University of South Florida - Tampa FL

International Classification:

A01N 102

US Classification:

435 11, 435368, 435325

Abstract:

Bone marrow stromal cells (BMSC) differentiate into neuron-like phenotypes in vitro and in vivo, engrafted into normal or denervated rat striatum. The BMSC did not remain localized to the site of the graft, but migrated throughout the brain and integrated into specific brain regions in various architectonic patterns. The most orderly integration of BMSC was in the laminar distribution of cerebellar Purkinje cells, where the BMSC-derived cells took on the Purkinje phenotype. The BMSC exhibited site-dependent differentiation and expressed several neuronal markers including neuron-specific nuclear protein, tyrosine hydroxylase and calbindin. BMSC can be used to target specific brain nuclei in strategies of neural repair and gene therapy.

US Patent:

7323333, Jan 29, 2008

Filed:

Mar 31, 2004

Appl. No.:

10/815388

Inventors:

Pablo Caviedes - Santiago, CL
Raul Caviedes - Santiago, CL
Thomas B. Freeman - Tampa FL, US
Juan A. Asenjo - Santiago, CL
Barbara A. Andrews - Santiago, CL
Dario Sepúlveda - Santiago, CL
Christian Arriagada - Santiago, CL
Julio Salazar Rivera - Santiago, CL

Assignee:

University of South Florida - Tampa FL
University of Chile

International Classification:

C12N 5/08

US Classification:

435368, 435325, 435366, 435383

Abstract:

The subject invention pertains to materials and methods for inhibiting process formation and extension by cells in culture. The subject invention further includes cultures of process-forming cells wherein formation and extension of processes have been inhibited. In another aspect, the subject invention concerns methods of transplantation using process-forming cells that have been cultured by the process-inhibiting methods of the invention.

US Patent:

7416885, Aug 26, 2008

Filed:

Feb 7, 2003

Appl. No.:

10/359854

Inventors:

Thomas B. Freeman - Tampa FL, US
Pablo Caviedes - Santiago, CL
Raul Caviedes - Santiago, CL

Assignee:

University of South Florida - Tampa FL
University of Chile

International Classification:

C12N 5/00

US Classification:

435325

Abstract:

The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines and cultures. The invention also concerns proliferation factors, and compositions containing the factors, which are capable of increasing the proliferation potential of any human or other animal cell in culture. The subject invention further pertains to a method for proliferation cells in culture by contacting cells with the proliferation factors. The proliferated cells can range in plasticity and can include, for example, blast cells, fertilized ova, non-fertilized gametes, embryonic stem cells, adult stem cells, precursor or progenitor cells, and highly specialized cells. Optionally, the cells can be induced to cease proliferation. The proliferation cells of the subject invention are useful for cell therapy, cell/gene therapy, biological production of molecules, and as in vitro models for research, toxicity testing, and drug development.

US Patent:

7699854, Apr 20, 2010

Filed:

May 4, 2006

Appl. No.:

11/381647

Inventors:

Rudy A. Mazzocchi - Melbourne FL, US
Matthew S. Solar - Indialantic FL, US
Thomas B. Freeman - Tampa FL, US

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

A61B 19/00

US Classification:

606130

Abstract:

This document discusses trajectory guides that include an instrument guide with at least one lumen angled with respect to an orthogonal or other through-axis. In one example, patterned lumens on the instrument guide provide a mirror image pattern of trajectory axes intersecting a target plane. In another example, height adjustment of the instrument guide extends these or other targeting techniques to a three-dimensional volume. This document also describes a method of manufacturing such an instrument guide, which is also applicable to manufacturing an instrument guide providing parallel lumens.

US Patent:

7896889, Mar 1, 2011

Filed:

Feb 20, 2003

Appl. No.:

10/370090

Inventors:

Rudy A. Mazzocchi - Melbourne FL, US
Matthew S. Solar - Indialantic FL, US
Thomas B. Freeman - Tampa FL, US

Assignee:

Medtronic, Inc. - Minneapolis MN
University of South Florida Research Foundation, Inc. - Tampa FL

International Classification:

A61B 19/00

US Classification:

606130

Abstract:

This document discusses trajectory guides that include an instrument guide with at least one lumen angled with respect to an orthogonal or other through-axis. In one example, patterned lumens on the instrument guide provide a mirror image pattern of trajectory axes intersecting a target plane. In another example, height adjustment of the instrument guide extends these or other targeting techniques to a three-dimensional volume. This document also describes a method of manufacturing such an instrument guide, which is also applicable to manufacturing an instrument guide providing parallel lumens.

US Patent:

7963980, Jun 21, 2011

Filed:

Apr 18, 2007

Appl. No.:

11/736627

Inventors:

Thomas B. Freeman - Tampa FL, US
Wesley Johnson - Tampa FL, US

Assignee:

University of South Florida - Tampa FL

International Classification:

A61B 17/80

US Classification:

606286, 606280, 606287

Abstract:

An anti-subsidence, anti-translocation, fusion compression cervical plate system with interface visualization, drill guide and temporary pin is provided. In one embodiment the invention provides a vertebral plate for minimizing the ability of an inter-body cage, filled with bone (or BMP-soaked sponges, etc. ), to telescope into the vertebral body and to minimize failure due to cages that telescope into adjacent vertebral bodies on a delayed basis after surgery, as well as creation of reverse lordosis due to such telescoping. Another embodiment provides method to reduce the gap between the inter-body cage and the vertebral body end plate intra-operatively using compression from the plate caused by an offset between the screw bores on the plate and the drill holes, as established with an asymmetric drill guide.

US Patent:

7981120, Jul 19, 2011

Filed:

Apr 23, 2007

Appl. No.:

11/738893

Inventors:

Rudy A. Mazzocchi - Melbourne FL, US
Matthew S. Solar - Indialantic FL, US
Thomas B. Freeman - Tampa FL, US

Assignee:

University of South Florida - Tampa FL

International Classification:

A61B 19/00

US Classification:

606129, 606130, 600417, 600429

Abstract:

This document discusses trajectory guides that include an instrument guide with at least one lumen angled with respect to an orthogonal or other through-axis. In one example, patterned lumens on the instrument guide provide a mirror image pattern of trajectory axes intersecting a target plane. In another example, height adjustment of the instrument guide extends these or other targeting techniques to a three-dimensional volume. This document also describes a method of manufacturing such an instrument guide, which is also applicable to manufacturing an instrument guide providing parallel lumens.

US Patent:

8012159, Sep 6, 2011

Filed:

May 20, 2005

Appl. No.:

10/908648

Inventors:

Thomas B. Freeman - Tampa FL, US
James P. O'Connor - Billerica MA, US

Assignee:

University of South Florida - Tampa FL

International Classification:

A61B 19/00

US Classification:

606130

Abstract:

The present invention makes a grid array, for use in the transplantation of materials into the brain, in the shape of a predetermined structure, such as the putamen, based on anatomic analysis the structure. Alternatively, a smaller grid array is used which only includes the putamen target and not the caudate target, and also has two windows within the grid array. Because of the smaller size of this grid array as well as the two cutouts in the middle, it is possible for the first time to observe the brain as the needle enters the brain through the grid array. The previous solid and larger grid array made the passage of the needle into the brain a blind maneuver. Therefore if there was cortical bleeding at the time of needle insertion, it would not be known until after the transplant was done.