Thomas E Gajewski

US Patent:

6553772, Apr 29, 2003

Filed:

May 9, 2002

Appl. No.:

10/140826

Inventors:

Paul William Belanger - East Amherst NY
William R. Esposito - Amherst NY
Thomas Edward Gajewski - Tonawanda NY

Assignee:

Praxair Technology, Inc. - Danbury CT

International Classification:

F25B 1902

US Classification:

62 512, 62657

Abstract:

A refrigeration system having a partially decentralized operating control system wherein five defined separate controllers control either one or more than one defined variables.

US Patent:

6716422, Apr 6, 2004

Filed:

Oct 8, 1998

Appl. No.:

09/168832

Inventors:

Thomas F. Gajewski - Chicago IL
Francesca Fallarino - Peruga, IT

Assignee:

ARCH Development Corporation - Chicago IL
Genetics Institute Incorporated - Cambridge MA

International Classification:

A61K 3820

US Classification:

424 852, 424 851, 424 937, 424 9371, 4241841, 4241851, 4242041, 4242651, 4242771, 4242781, 514 2, 530351, 530300

Abstract:

The invention provides methods of inducing the production of cytolytic T lymphocytes directed against malignancy or infectious agent by a mammal and treating such disease such that deleterious side effects are minimized and treatment of metastatic melanomas are surprisingly and dramatically improved.

US Patent:

6745794, Jun 8, 2004

Filed:

Jun 7, 2002

Appl. No.:

10/163298

Inventors:

Thomas Edward Gajewski - North Tonawanda NY

Assignee:

Praxair Technology, Inc. - Danbury CT

International Classification:

F16K 1114

US Classification:

137630, 13763015, 13759916

Abstract:

A valve assembly in which a primary valve is provided within a primary passageway of a valve housing to control flow rates of a fluid flow within the primary passageway. The primary valve is moved between open and closed positions relative to a valve seat defined in the primary passageway to produce higher flow rates as the primary valve is moved towards the open position and lower flow rates as the primary valve is moved towards the closed position. As the primary valve is moved towards the closed position an ever increasing flow rate occurs within a secondary passageway formed in the primary valve by at least an orifice. A secondary needle valve, projecting into the orifice, meters such ever increasing flow rate and thereby the lower flow rates of the fluid flow. The secondary needle valve can be attached to the valve housing and thus, be fixed in position or can be attached to a valve steam to control the degree to which the secondary needle valve projects into the orifice.

US Patent:

7381401, Jun 3, 2008

Filed:

Jan 10, 2005

Appl. No.:

11/032516

Inventors:

Thomas F. Gajewski - Chicago IL, US

Assignee:

The University of Chicago - Chicago IL

International Classification:

A61K 49/00

US Classification:

424 92

Abstract:

T cell anergy has been correlated with defective Ras signaling. However, neither a causal relationship nor the mechanism of Ras hypoactivation have been established. Using adenoviral transduction of CAR Tg T cells to enable genetic manipulation in nonproliferating cells, we show that Ras61L restores IL-2 production and MAP kinase signaling in T cells anergized in vitro or in vivo. A gene array screen revealed upregulated diacylglycerol kinase (DGK) in the anergic state, which was confirmed by RT-PCR and Western blot analysis. A DGK inhibitor significantly restored IL-2 production by anergic cells. Our data support a causal role for DGK and defective Ras signaling in T cell anergy.

US Patent:

7547422, Jun 16, 2009

Filed:

Mar 13, 2006

Appl. No.:

11/373239

Inventors:

Vasilis Papavassiliou - Williamsville NY, US
Shawn Michael Cecula - Lewiston NY, US
Perry Pacouloute - Williamsville NY, US
Thomas Edward Gajewski - North Tonawanda NY, US

Assignee:

Praxair Technology, Inc. - Danbury CT

International Classification:

B01J 8/00
C01B 3/24

US Classification:

422194, 422198, 422211, 422215, 422222, 481279, 481987

Abstract:

A catalytic reactor having a mixing section connected to a downstream reaction section containing a catalyst to promote a reaction of oxygen and a hydrocarbon fed to the catalytic reactor. The mixing section is provided with a flame arrestor to prevent a stable flame from propagating should any reaction of oxygen and hydrocarbons occur during mixing. The flame arrestor permits flow in both axial and radial directions to promote mixing. Baffle elements and a downstream static mixer can also be used. The catalyst is preferably in the form of monolithic blocks enclosed by a ceramic tube that is maintained as a unitary catalyst assembly that can be removed for replacement and installation of the catalyst as a single unit.

US Patent:

60803991, Jun 27, 2000

Filed:

Apr 23, 1998

Appl. No.:

9/064964

Inventors:

Thomas F. Gajewski - Chicago IL
Francesca Fallarino - Chicago IL

Assignee:

Arch Development Corporation - Chicago IL

International Classification:

A61K 3820
A61K 4505
A61K 3912
A61K 39002
C07K 1454

US Classification:

424 852

Abstract:

The invention provides methods of inducing the production of cytolytic T lymphocytes directed against malignancy or infectious agent by a mammal and treating such disease such that deleterious side effects are minimized and treatment of metastatic melanomas are surprisingly and dramatically improved.

US Patent:

20210139994, May 13, 2021

Filed:

Sep 18, 2020

Appl. No.:

16/948455

Inventors:

- Chicago IL, US
Yuanyuan ZHA - Chicago IL, US
Robbert M. SPAAPEN - Chicago IL, US
Thomas F. GAJEWSKI - Chicago IL, US

Assignee:

The University of Chicago - Chicago IL

International Classification:

C12Q 1/6886
G01N 33/569
G01N 33/574
G16H 50/30
A61K 31/713
A61K 45/06
C12N 15/113

Abstract:

Embodiments concern methods and composition related to anergic T-cells in patients, such as cancer patients.

US Patent:

20180312929, Nov 1, 2018

Filed:

Mar 27, 2018

Appl. No.:

15/937044

Inventors:

- Chicago IL, US
Yuanyuan ZHA - Chicago IL, US
Robbert M. SPAAPEN - Chicago IL, US
Thomas F. GAJEWSKI - Chicago IL, US

International Classification:

C12Q 1/6886
G16H 50/30
G06F 19/00
C12N 15/113
A61K 31/713
G01N 33/574
A61K 45/06
G01N 33/569

Abstract:

Embodiments concern methods and composition related to anergic T-cells in patients, such as cancer patients.