Thomas E Gilbert

US Patent:

8535719, Sep 17, 2013

Filed:

Jul 6, 2007

Appl. No.:

11/825540

Inventors:

Stephen F. Badylak - Pittsburgh PA, US
Donald O. Freytes - Pittsburgh PA, US
Thomas W. Gilbert - Pittsburgh PA, US
Jianjun Guan - Dublin OH, US
John Stankus - Campbell CA, US
William R. Wagner - Wexford PA, US

Assignee:

University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

A61K 9/70

US Classification:

424484, 424426, 424486, 424551, 424574, 424 937, 5147723

Abstract:

Provided herein is a biohybrid elastomeric scaffold comprising a synthetic polymeric component and a biological polymeric component. The scaffold can be fabricated to have many different forms, non-limiting examples of which include a non-woven fibrous mesh or in a porous composite. Methods of use of the biohybrid elastomeric scaffolds in wound healing and tissue regeneration are also provided.

US Patent:

20070166396, Jul 19, 2007

Filed:

Jan 5, 2007

Appl. No.:

11/650015

Inventors:

Stephen Badylak - Pittsburgh PA, US
Thomas Gilbert - Pittsburgh PA, US
Alejandro Nieponice - Buenos Aires, AR

Assignee:

University of Pittsburgh - Pittsburgh PA

International Classification:

A61K 35/38

US Classification:

424551000

Abstract:

Provided are medical devices for implantation in patients having suffered the loss of or damage to at least part of their esophagus. The medical device connects the esophagus or remaining part thereof with the stomach to form a gastro-esophageal junction that promotes healing and encourages new host tissue growth while distributing the load and decreasing tension at the anastomotic site. The medical device comprises extracellular matrix shaped into a conformation that more closely approximates the geometry of the native gastro-esophageal junction than does direct attachment of the stomach to the shortened esophagus. Molds useful in manufacturing the medical device and methods of use of the device are also described herein.

US Patent:

20110184439, Jul 28, 2011

Filed:

May 8, 2009

Appl. No.:

12/991809

Inventors:

William D. Anderson - Pittsburgh PA, US
Stephen F. Badylak - Pittsburgh PA, US
Thomas W. Gilbert - Pittsburgh PA, US
John M. Wainwright - Churchill PA, US

Assignee:

University of Pittsburgh-Of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

A61B 17/08

US Classification:

606151

Abstract:

Provided herein is a device to occlude a hole in a wall of an organ or tissue. In another embodiment, a device is provided which comprises an extracellular matrix-derived material and an adhesive to occlude a hole in a wall of an organ or tissue. Provided are devices prepared from extracellular matrix-derived cell-growth scaffolding to repair defects in walls of organs or tissues. Also provided are methods for preparing the device as well as for using the device.

US Patent:

20110262498, Oct 27, 2011

Filed:

Dec 4, 2009

Appl. No.:

13/132708

Inventors:

Thomas Gilbert - Pittsburgh PA, US
Michelle Manni - Sewickley PA, US
Tim D. Oury - Wexford PA, US

Assignee:

University of Pittsburgh-Of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

A61K 9/12
A61P 11/00
A61K 35/22
A61K 9/00
A61K 35/12

US Classification:

424400, 424 43, 424520, 424558

Abstract:

Provided herein are methods of preventing, lessening or treating pulmonary fibrosis in a subject. The methods comprise delivering an amount of a powdered extracellular matrix (ECM)-derived material to the respiratory system of the subject effective to prevent, lessen or treat pulmonary fibrosis in a subject. Also provided is an apparatus for delivering the powdered ECM-derived material to a subject.

US Patent:

20110288654, Nov 24, 2011

Filed:

May 16, 2011

Appl. No.:

13/108074

Inventors:

Stephen F. Badylak - Pittsburgh PA, US
Thomas W. Gilbert - Pittsburgh PA, US
Alejandro Nieponice - Buenos Aires, AR

Assignee:

University of Pittsburgh-Of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

A61F 2/04

US Classification:

623 2364

Abstract:

Provided are medical devices for implantation in patients having suffered the loss of or damage to at least part of their esophagus. The medical device connects the esophagus or remaining part thereof with the stomach to form a gastro-esophageal junction that promotes healing and encourages new host tissue growth while distributing the load and decreasing tension at the anastomotic site. The medical device comprises extracellular matrix shaped into a conformation that more closely approximates the geometry of the native gastro-esophageal junction than does direct attachment of the stomach to the shortened esophagus. Molds useful in manufacturing the medical device and methods of use of the device are also described herein.

US Patent:

20150182663, Jul 2, 2015

Filed:

Dec 9, 2014

Appl. No.:

14/564624

Inventors:

- Pittsburgh PA, US
Thomas W. Gilbert - Pittsburgh PA, US
Alejandro Nieponice - Buenos Aires, AR

International Classification:

A61L 27/36
A61F 2/04

Abstract:

Provided are medical devices for implantation in patients having suffered the loss of or damage to at least part of their esophagus. The medical device connects the esophagus or remaining part thereof with the stomach to form a gastro-esophageal junction that promotes healing and encourages new host tissue growth while distributing the load and decreasing tension at the anastomotic site. The medical device comprises extracellular matrix shaped into a conformation that more closely approximates the geometry of the native gastro-esophageal junction than does direct attachment of the stomach to the shortened esophagus. Molds useful in manufacturing the medical device and methods of use of the device are also described herein.