Thomas B Givens

US Patent:

6502040, Dec 31, 2002

Filed:

Jun 30, 1999

Appl. No.:

09/345080

Inventors:

Thomas Givens - Rougemont NC
Paul Braun - Durham NC
Lisa Beck - Durham NC

Assignee:

bioMerieux, Inc. - Durham NC

International Classification:

G01N 2100

US Classification:

702 22, 702 28, 702 30, 702 32

Abstract:

A method for presenting relationships between data from a thrombosis-hemostasis assay on an unknown sample and data from a purality of assays on known samples, which can be in the form of a topological feature map wherein spatial locations within the map correspond to intrinsic features of the known samples. The position of the unknown sample is superimposed on the positions of the known samples. An alternative presentation is showing the distance of each of a purality of predictor variables from an unknown sample to the mean values of a known population.

US Patent:

6564153, May 13, 2003

Filed:

May 7, 2001

Appl. No.:

09/850255

Inventors:

Paul Braun - Durham NC
Thomas B. Givens - Rougemont NC
Timothy J. Fischer - Oro Valley AZ

Assignee:

bioMerieux - Durham NC

International Classification:

G01N 2100

US Classification:

702 22, 702 30, 702 32, 702 19, 436 69

Abstract:

A method is disclosed for predicting the presence of an abnormal level of one or more proteins in the clotting cascade from at least one time-dependent measurement profile. At least one time-dependent measurement on an unknown sample is performed and a respective property of said sample is measured over time so as to derive a time-dependent measurement profile. A set of a plurality of predictor variables are defined which sufficiently define the data of the time-dependent measurement profile. A model is then derived that represents the relationship between the abnormality and the set of predictor variables. Subsequently, the model is utilized to predict which protein or proteins in the clotting cascade are at an abnormal level, with the prediction being a more informative prediction than clot time alone.

US Patent:

20010053959, Dec 20, 2001

Filed:

Jul 30, 2001

Appl. No.:

09/918214

Inventors:

Thomas Givens - Rougemont NC, US
Paul Braun - Durham NC, US
Timothy Fischer - Raleigh NC, US

International Classification:

G06F019/00
G01N031/00

US Classification:

702/022000

Abstract:

A method and apparatus are disclosed for predicting the presence of at least one congenital or acquired imbalance or therapeutic condition associated with thrombosis/hemostasis from at least one time-dependent measurement profile. At least one time-dependent measurement on an unknown sample is performed and a respective property of said sample is measured over time so as to derive a time-dependent measurement profile. A set of a plurality of predictor variables are defined which sufficiently define the data of the time-dependent measurement profile. A model is then derived that represents the relationship between the congenital or acquired imbalance or therapeutic condition, and the set of predictor variables. Subsequently, the model is utilized to predict the existence of the congenital or acquired imbalance or therapeutic condition in the unknown sample.

US Patent:

57085919, Jan 13, 1998

Filed:

Jun 7, 1995

Appl. No.:

8/477839

Inventors:

Thomas B. Givens - Rougemont NC
Paul Braun - Durham NC
Timothy J. Fischer - Raleigh NC

Assignee:

Akzo Nobel N.V. - Arnhem

International Classification:

G01N 3349
G06F 1900

US Classification:

364497

Abstract:

A method and apparatus are disclosed for predicting the presence of at least one congenital or acquired imbalance or therapeutic condition associated with thrombosis/hemostasis from at least one time-dependent measurement profile. At least one time-dependent measurement on an unknown sample is performed and a respective property of said sample is measured over time so as to derive a time-dependent measurement profile. A set of a plurality of predictor variables are defined which sufficiently define the data of the time-dependent measurement profile. A model is then derived that represents the relationship between the congenital or acquired imbalance or therapeutic condition, and the set of predictor variables. Subsequently, the model is utilized to predict the existence of the congenital or acquired imbalance or therapeutic condition in the unknown sample.

US Patent:

63211645, Nov 20, 2001

Filed:

Dec 31, 1997

Appl. No.:

9/001647

Inventors:

Paul Braun - Durham NC
Thomas B. Givens - Rougemont NC
Timothy J. Fischer - Raleigh NC

Assignee:

Akzo Nobel N.V.

International Classification:

G01N 2100

US Classification:

702 22

Abstract:

A method is disclosed for predicting the presence of an abnormal level of one or more proteins in the clotting cascade from at least one time-dependent measurement profile. At least one time-dependent measurement on an unknown sample is performed and a respective property of said sample is measured over time so as to derive a time-dependent measurement profile. A set of a plurality of predictor variables are defined which sufficiently define the data of the time-dependent measurement profile. A model is then derived that represents the relationship between the abnormality and the set of predictor variables. Subsequently, the model is utilized to predict which protein or proteins in the clotting cascade are at an abnormal level, with the prediction being a more informative prediction than clot time alone.

US Patent:

61014494, Aug 8, 2000

Filed:

May 21, 1997

Appl. No.:

8/859773

Inventors:

Thomas B. Givens - Rougemont NC
Paul Braun - Durham NC
Timothy J. Fischer - Raleigh NC

Assignee:

Akzo Nobel N.V. - Arnhem

International Classification:

G01N 2100

US Classification:

702 22

Abstract:

A method and apparatus are disclosed for predicting the presence of at least one congenital or acquired imbalances or therapeutic condition associated with thrombosis/hemostasis from at least one time-dependent measurement profile. At least one time-dependent measurement in a sample is performed and a respective property of sample is measured over time so as to derive a time-dependent measurement profile. A set of a plurality of predictor variables are defined which sufficiently define the data of the time-dependent measurement profile. A model is then derived that represents the relationship between the congenital or acquired imbalance or therapeutic condition, and the set of predictor variables. Subsequently, the model is utilized to predict the existence of the congenital or acquired imbalance or therapeutic condition in a sample.

US Patent:

54568846, Oct 10, 1995

Filed:

Jun 14, 1994

Appl. No.:

8/261129

Inventors:

Gregory D. Lewis - Cary NC
Roger G. Roberts - Raleigh NC
Thomas B. Givens - Rougemont NC

Assignee:

Akzo Nobel N.V. - Arnhem

International Classification:

G01N 2113

US Classification:

422 66

Abstract:

A mechanism is provided for loading the cassette into an operative relationship with a machine for dispensing contents of the cassette for use by the machine. The loading mechanism includes a base adapted for being fixedly mounted on the machine. The loading mechanism also includes a holder for releasably holding the cassette. The holder has one end pivotally connected to the base for pivoting about an axis for moving the cassette between a first position at which the holder releasably receives the cassette and a second position at which the cassette is placed in an operative relationship with the machine. The loading mechanism further includes a linkage mechanism coupled between the base and the holder for translating the holder along the axis as the holder is pivoted between the first and second positions.

US Patent:

53645928, Nov 15, 1994

Filed:

Jul 22, 1992

Appl. No.:

7/916712

Inventors:

Gregory D. Lewis - Cary NC
Roger G. Roberts - Raleigh NC
Thomas B. Givens - Rougemont NC

Assignee:

Akzo N.V. - Arnhem

International Classification:

G01N 2113
B65H 108

US Classification:

422 63

Abstract:

A cassette for storing and dispensing cuvettes and comprising an enclosable frame defining an interior volume for storing cuvettes. The frame includes a removable cover to aid in loading a plurality of cuvettes into the cassette. The frame also includes a side wall having a pivotally mounted door for pivoting between a closed position and an open position for dispensing the cuvettes from the cassette. And, the frame includes a locking mechanism for locking the door in the closed position to avoid an inadvertent dispensing of cuvettes. According to another aspect of the invention, a mechanism is provided for loading the cassette into an operative relationship with a machine for dispensing contents of the cassette for use by the machine. The loading mechanism includes a base adapted for being fixedly mounted on the machine. The loading mechanism also includes a holder for releasably holding the cassette.