Thomas M Lane

US Patent:

8258266, Sep 4, 2012

Filed:

May 27, 2009

Appl. No.:

12/472877

Inventors:

Shrikant Deshpande - Fremont CA, US
Haichun Huang - Fremont CA, US
Mohan Srinivasan - Cupertino CA, US
Josephine M. Cardarelli - San Carlos CA, US
Changyu Wang - Fremont CA, US
David B. Passmore - San Carlos CA, US
Vangipuram Rangan - Pleasant Hill CA, US
Thomas E. Lane - Irvine CA, US
Hans S. Keirstead - Irvine CA, US
Michael T. Liu - Irvine CA, US

Assignee:

Medarex, Inc. - Princeton NJ

International Classification:

C07K 16/00
C12P 21/08
A61K 39/395
A61K 39/40
C12N 5/02
C12N 5/16
C07K 1/00

US Classification:

5303871, 5303873, 5303879, 5303881, 53038815, 5303882, 53038823, 5303911, 4241301, 4241321, 4241341, 4241361, 4241391, 4241411, 4241421, 4241581, 4241781, 435325, 435326, 435328, 435331, 435335

Abstract:

The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.

US Patent:

8263153, Sep 11, 2012

Filed:

Apr 19, 2005

Appl. No.:

11/547986

Inventors:

Nynne M. Forchhammer - Hedehusene, DK
Beth Fryksdale - San Jose CA, US
Keith Hayes - Florence KY, US
Csilla Kollar - Midland MI, US
Thomas H. Lane - Midland MI, US
Anthony Revis - Freeland MI, US

Assignee:

Dow Corning Corporation - Midland MI

International Classification:

A23L 2/72

US Classification:

426422, 426 11, 4263303, 426423, 426424

Abstract:

The present invention provides a method for preventing or reducing haze development in a beverage. Silane-treated silica filter media are synthesized. By contacting the beverage with the silane-treated silica filter, one or more haze-forming components bind to the silane-treated silica filter media and are removed by filtration. In addition, particulates in the beverage are removed by filtration. Beverages that tend to develop haze on standing and/or chilling such as alcoholic, fruit, and vegetable beverages, are suitable for the present invention. This haze in a beverage is mainly caused by polyphenols and proteins. The present invention provides a method that can reduce the levels of both polyphenols and proteins. The silica filter media useful for the present method include rice hull ash, oat hull ash, or diatomaceous earth.

US Patent:

20050191293, Sep 1, 2005

Filed:

Dec 10, 2004

Appl. No.:

11/009731

Inventors:

Shrikant Deshpande - Freemont CA, US
Haichun Huang - Fremont CA, US
Mohan Srinivasan - Cupertino CA, US
Josephine Cardarelli - San Carlos CA, US
Changyu Wang - Fremont CA, US
David Passmore - Mountain View CA, US
Vangipuram Rangan - Pleasant Hill CA, US
Thomas Lane - Irvine CA, US
Hans Keirstead - Irvine CA, US
Michael Liu - Irvine CA, US

International Classification:

A61K039/395
C07K016/28

US Classification:

424143100, 530388220

Abstract:

The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.

US Patent:

20060083776, Apr 20, 2006

Filed:

Oct 11, 2005

Appl. No.:

11/248017

Inventors:

Richard Bott - Burlingame CA, US
Kurt Brandstadt - Midland MI, US
Csilla Kollar - Midland MI, US
Thomas Lane - Midland MI, US
Donald Liles - Midland MI, US
Mae Saldjeno - Daly City CA, US
Xavier Thomas - Foix, FR
Kevin Murphy - Midland MI, US
Gerald Schalau - Freeland MI, US

International Classification:

A61L 15/00

US Classification:

424445000

Abstract:

A multi-layer dressing and controlled-release composition for topical application to a substrate include an emulsion and an active agent incorporated into the emulsion. The active agent includes a protein. A method of delivering the active agent to the substrate provides the emulsion and incorporates the active agent into the emulsion for delivery of the active agent to the substrate. Multi-layer dressings and methods particularly suited for management of wound exudate and effective debridement of wound eschar.

US Patent:

20070218115, Sep 20, 2007

Filed:

Oct 27, 2004

Appl. No.:

10/576356

Inventors:

Richard Bott - Burlingame CA, US
Kurt Brandstadt - Midland MI, US
Csilla Kollar - Midland MI, US
Thomas Lane - Midland MI, US
Donald Liles - Midland MI, US
Mae Saldjeno - Dale City CA, US
Xavier Thomas - Foix, FR

International Classification:

A61K 9/70

US Classification:

424445000

Abstract:

A multi-layer dressing and controlled-release composition for topical application to a substrate include an emulsion and an active agent incorporated into the emulsion. The active agent includes a protein. A method of delivering the active agent to the substrate provides the emulsion and incorporates the active agent into the emulsion for delivery of the active agent to the substrate.

US Patent:

20120230998, Sep 13, 2012

Filed:

May 23, 2012

Appl. No.:

13/478786

Inventors:

Shrikant DESHPANDE - Fremont CA, US
Haichun HUANG - Fremont CA, US
Mohan SRINIVASAN - Cupertino CA, US
Josephine M. CARDARELLI - San Carlos CA, US
Changyu WANG - Fremont CA, US
David PASSMORE - Mountain View CA, US
Vangipuram RANGAN - Pleasant Hill CA, US
Thomas E. LANE - Irvine CA, US
Hans S. KEIRSTEAD - Irvine CA, US
Michael T. LIU - Irvine CA, US

Assignee:

MEDAREX, INC. - Princeton NJ

International Classification:

A61K 39/395
A61P 25/00
A61P 19/02
A61P 29/00
A61P 1/00
A61P 9/10
A61P 17/00
A61P 11/00
A61P 25/28
A61K 48/00
A61P 13/12
C12N 5/02
A61P 3/10

US Classification:

4241351, 435375, 4241391, 4241331

Abstract:

The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.

US Patent:

55354203, Jul 9, 1996

Filed:

Dec 14, 1994

Appl. No.:

8/356131

Inventors:

James Kardach - San Jose CA
Sung S. Cho - Sunnyvale CA
Nicholas B. Peterson - San Jose CA
Thomas R. Lane - San Jose CA

Assignee:

Intel Corporation - Santa Clara CA

International Classification:

G06F 1324

US Classification:

395868

Abstract:

A computer architecture which provides for the dynamic configuration of peripheral interrupts. A global router is implemented for mapping interrupts received over a multiple-line shared interrupt bus to correspond to system standard IRQ interrupt signals for a programable interrupt controller (PIC). The global router may configure interrupts to be both level sensitive and edge-triggered interrupts as well as being sharable among multiple devices. The global router further provides its interrupts to a shared interrupt bus which may receive other system interrupts for propagation to the computer system's PIC. The global router provides a centrally located motherboard resource that provides a totally flexible interrupt configuration scheme.

US Patent:

56219008, Apr 15, 1997

Filed:

May 17, 1995

Appl. No.:

8/442690

Inventors:

Thomas R. Lane - San Jose CA
James P. Kardach - Saratoga CA

Assignee:

Intel Corporation - Santa Clara CA

International Classification:

G06F 1336
G06F 13372

US Classification:

395300

Abstract:

A computer system has both positive decode agents and subtractive decode agents that are targets of bus transactions, as well as an agent that does not perform a positive decode of a bus transaction, yet does claim bus transactions on behalf of agents to whom a bus transaction is directed.