Thomas Michael Laporte

US Patent:

7671199, Mar 2, 2010

Filed:

Apr 20, 2007

Appl. No.:

11/737787

Inventors:

Gerard A. Crispino - Lawrenceville NJ, US
Mourad Hamedi - Eatontown NJ, US
Thomas L. LaPorte - Kendall Park NJ, US
John E. Thornton - Newtown PA, US
Jaan A. Pesti - Yardley PA, US
Zhongmin Xu - Princeton NJ, US
Paul C. Lobben - Lawrenceville NJ, US
David K. Leahy - Hightstown NJ, US
Jale Muslehiddinoglu - Hightstown NJ, US
Chiajen Lai - Kendall Park NJ, US
Lori Ann Spangler - Churchville PA, US
Robert P. Discordia - Pennington NJ, US
Francis S. Gibson - Pennington NJ, US

Assignee:

Britsol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 487/04
A61K 31/53
A61P 3/10

US Classification:

544183, 514243

Abstract:

The invention relates to an improved process for preparing [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester of the formula:Compound I has been shown to be useful for the treatment of certain types of cancer.

US Patent:

20050135978, Jun 23, 2005

Filed:

Oct 8, 2004

Appl. No.:

10/962072

Inventors:

Mourad Hamedi - Eatontown NJ, US
Thomas LaPorte - Kendall Park NJ, US
Yeung Chan - Kendall Park NJ, US

International Classification:

F28D021/00

US Classification:

422198000, 422201000, 422202000

Abstract:

The geometry of the reactor is tailored to increase the heat transfer capacity of the initial sections of the reactor columns where the greatest heat is generated. This is accomplished by reducing the inner diameter of the initial column sections relative to that of the final column sections and by increasing the rate of heat transfer from to the coolant proximate the initial column sections by increasing the velocity of coolant surrounding the initial column sections. Further, the coolant flow is directed in a direction perpendicular to the axis of each column by spaced, laterally offset baffles.

US Patent:

20050165233, Jul 28, 2005

Filed:

Nov 15, 2004

Appl. No.:

10/988791

Inventors:

Mourad Hamedi - Eatontown NJ, US
Thomas LaPorte - Kendall Park NJ, US
Daniel Watson - Lafayette CO, US
Lifen Shen - North Brunswick NJ, US
Eric Dowdy - Foster City CA, US
Jeffrey Depue - Hillsborough NJ, US
Yeung Chan - Kendall Park NJ, US

International Classification:

C07D043/14

US Classification:

544295000, 544230000

Abstract:

A method for continuous production of hydroxyazapirones, for example 6-hydroxybuspirone, using a modified reactor. The products of the invention are useful as pharmaceutical agents.