Thomas E Lavin

US Patent:

6380255, Apr 30, 2002

Filed:

Jul 14, 2000

Appl. No.:

09/617052

Inventors:

Thomas N. Lavin - Watchung NJ

Assignee:

Karo Bio AB - Huddinge

International Classification:

A61K 31195

US Classification:

514567, 514369, 514469, 514557, 514646

Abstract:

The present invention is directed to a method for treating dermal atrophy of the skin. The method of the invention includes applying a composition to the skin of a mammal suffering from dermal atrophy of the skin, and comprising at least one thyroid hormone compound or thyroid hormone-like compound together with a pharmacologically acceptable base suitable for topical application, wherein the thyroid hormone compound or the thyroid hormone-like compound binds to TR- or TR- with an equilibrium dissociation constant, K , of at least 10 M. The invention is also directed to an article of manufacture comprising packaging material and a pharmaceutical agent contained within the packaging material, wherein the pharmaceutical agent is therapeutically effective for treating dermal atrophy of the skin.

US Patent:

20020123521, Sep 5, 2002

Filed:

Feb 25, 2002

Appl. No.:

10/081397

Inventors:

Thomas Lavin - Watchung NJ, US

International Classification:

A61K031/41
A61K031/195
G01N033/566

US Classification:

514/381000, 514/567000, 436/501000

Abstract:

The present invention is directed to a method for treating dermal atrophy of the skin. The method of the invention includes applying a composition to the skin of a mammal suffering from dermal atrophy of the skin, and comprising at least one thyroid hormone compound or thyroid hormone-like compound together with a pharmacologically acceptable base suitable for topical application, wherein the thyroid hormone compound or the thyroid hormone-like compound binds to TR- or TR- with an equilibrium dissociation constant, K, of at least 10M. The invention is also directed to an article of manufacture comprising packaging material and a pharmaceutical agent contained within the packaging material, wherein the pharmaceutical agent is therapeutically effective for treating dermal atrophy of the skin.

US Patent:

20060292194, Dec 28, 2006

Filed:

Jun 20, 2006

Appl. No.:

11/455971

Inventors:

Thomas Lavin - Watchung NJ, US

International Classification:

A61K 31/198
A61K 9/127

US Classification:

424401000, 424450000, 977907000, 514567000

Abstract:

A topical preparation for treating first and second degree burns includes TriAc. The topical preparation preferably includes less than 10 mg of TriAc per 100 ml of pharmaceutical excipient base. In another embodiment, a topical preparation includes TriAc for decreasing cellulite. In this embodiment, the topical preparation is preferably applied only before exercise. In a preferred embodiment, the preparation is applied only intermittently, preferably no more than three times a week, or in amounts sufficient to not downregulate receptor number and become inefficacious.

US Patent:

20090306249, Dec 10, 2009

Filed:

May 29, 2009

Appl. No.:

12/474810

Inventors:

Thomas Lavin - Watchung NJ, US
Houssam Toutanji - Madison AL, US
John Gilbert - Huntsville AL, US

Assignee:

OPTECHNOLOGY, INC. - Huntsville AL

International Classification:

C04B 26/04

US Classification:

524 4, 524 8

Abstract:

A method of improving the stress strain characteristics, the ductility, the energy absorbing characteristics, the fractal roughness and the material roughness of a cementitious mix includes adding at least 1%, by weight of the total weight of the cementitious mix of poly(vinyl butyrate) in addition to a reinforcing agent, preferably poly(vinyl alcohol). In a preferred embodiment, the amount of poly(vinyl butyrate) is about 40% to about 50%, by weight. This provides the optimum levels of performance of the characteristics listed above.

US Patent:

20100010092, Jan 14, 2010

Filed:

Dec 19, 2007

Appl. No.:

12/518870

Inventors:

Thomas N. Lavin - Watchung NJ, US
Catherine H. Koo - Watchung NJ, US

International Classification:

A61K 31/165
A61P 43/00

US Classification:

514618

Abstract:

A method for relieving, treating, improving or attenuating one or more symptoms of RLS and related movement disorders such as PLMS, and snoring ICSD 780.53-1 is disclosed. The method includes the administration to a host afflicted with RLS or related disorder a pharmaceutically effective amount of a modafinil compound or a related compound. The method of the present invention is to treat a host to reduce or diminish snoring, the unpleasant leg sensations associated with unwanted leg movements and to diminish or eliminate the unwanted, involuntary leg movements at rest, awake or asleep, typically occurring in the evenings and at night.

US Patent:

20100047332, Feb 25, 2010

Filed:

Jul 13, 2009

Appl. No.:

12/460049

Inventors:

Thomas Lavin - Watchung NJ, US

International Classification:

A61K 31/195
A61K 9/127
A61P 17/02

US Classification:

424450, 514567, 977773

Abstract:

A topical preparation for treating first and second degree burns includes TriAc. The topical preparation preferably includes less than 10 mg of TriAc per 100 ml of pharmaceutical excipient base. In another embodiment, a topical preparation includes TriAc for decreasing cellulite. In this embodiment, the topical preparation is preferably applied only before exercise. In a preferred embodiment, the preparation is applied only intermittently, preferably no more than three times a week, or in amounts sufficient to not downregulate receptor number and become inefficacious.

US Patent:

53173813, May 31, 1994

Filed:

Sep 18, 1989

Appl. No.:

7/408826

Inventors:

Thomas J. Lavin - Nutley NJ

Assignee:

Allied-Signal Inc. - Morris Township, Morris County NJ

International Classification:

G01C 1968

US Classification:

356350

Abstract:

A pneumatically dithered ring laser gyroscope features providing an oscillatory motion directly to a segment of the excited gas which serves as the laser photon source. Alternately switching ionizing potential between two cathodes in appropriately designed cavities establishes desired oscillatory gas velocities to effect emitted frequencies within the gyro, thereby permitting the detection of rotational rates below the "lock-in" rate of the undithered gyro.

US Patent:

62219111, Apr 24, 2001

Filed:

Mar 9, 1998

Appl. No.:

8/973627

Inventors:

Thomas N. Lavin - Watchung NJ
Anders B. Vahlquist - Uppsala, SE

Assignee:

Karo Bio AB - Huddinge

International Classification:

A61K 31195

US Classification:

514567

Abstract:

This invention relates to the use of topically applied thyroid hormone compounds and thyroid hormone-like compounds which are receptor binding ligands, either agonists or antagonists, to improve the appearance of the skin and underlying subcutaneous fat and improve certain medical conditions when applied topically. These compounds can be used to treat skin conditions such as stria, cellulite, roughened skin, actinic skin damage, intrinsically aged skin, photodamaged kin, lichen planus, ichthyosis, acne, psoriasis, wrinkled skin, corticosteroid atrophy, collagen deficient skin, and to diminish the size and improve the appearance of skin scarring from surgical or naturally occurring wounds, and to reduce the incidence of hyperkeratotic scarring. The thyroid agonists and antagonists may also promote differentiation and amelioration of dedifferentiated skin in premalignant lesions. The thyroid agonists and antagonists can be active in all organisms which contain the thyroid hormone receptors, notably amphibians, birds and subjects.