Thomas F Lavin

US Patent:

48166952, Mar 28, 1989

Filed:

Aug 31, 1987

Appl. No.:

7/091389

Inventors:

Thomas N. Lavin - Sausalito CA

International Classification:

G01H 1506

US Classification:

250573

Abstract:

An optical fluid detector (10) has an opaque housing (12). There is a first passage (14) through the housing (12) to receive a transparent, flexible plastic tube (50). A second passage (20) through the housing (12) orthogonally intersects the first passage (14). A first receptacle (22) in the housing has a light emitting diode (D1) with a housing having a flat surface (30) engaging the receptacle (22) and facing the second passage (20). A second receptacle (24) at a second end of the second passage on an opposing side of the first passage (14) from the first receptacle has a photodetector (Q1) with a housing having a flat surface (32) facing the second passage (20). An output circuit (33) is connected to the photodetector.

US Patent:

55008070, Mar 19, 1996

Filed:

Feb 21, 1992

Appl. No.:

7/839170

Inventors:

Thomas N. Lavin - Sausalito CA
Mark F. Norman - Petaluma CA
Teri E. Klein - San Francisco CA
George Seibel - San Francisco CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G06F 1711

US Classification:

364496

Abstract:

The present invention provides a predictive method for selecting organic compounds having useful pharmaceutical activity in a mammal. The method uses volume areas of similar molecules. When specific substituents of the test compound file predetermined volumes, the compound is subject to a binding assay. Only when the binding assay is positive, is the experimental compound recommended for further pharmaceutical evaluation. Example compounds are derivatives of 4-substituted 2,6-diiodophenols of the structure: ##STR1## where R. sup. 1 and R. sup. 2 are defined as aliphatic or substituted aliphatic moieties or aromatic or substituted aromatic moieties. Useful structures are described. The compounds have useful pharmaceutical properties to treat conditions in a human being, including hyperthyroidism, angina pectoris, arrythmia, and the like.