Thomas A Loftus

US Patent:

7970534, Jun 28, 2011

Filed:

Aug 21, 2007

Appl. No.:

11/894835

Inventors:

Thomas Michael Loftus - Great Falls VA, US
Dorian Sergio Araneda - Lovettesville VA, US
James Robert Sherman - Penn Laird VA, US

Assignee:

Blackbird Technologies, Inc. - Herndon VA

International Classification:

G01C 21/30

US Classification:

701208, 701207, 701213, 34053913

Abstract:

A handheld device and system includes a mapping module, a tracking module interoperative with the mapping module, and a communications module interoperative with the tracking module and the mapping module. At least two antennae are communicatively connected, via the communications module, to at least one central processing unit. At least one of said at least two antenna is suitable for communicating using at least two distinct communication modes.

US Patent:

8099235, Jan 17, 2012

Filed:

Jun 27, 2011

Appl. No.:

13/169569

Inventors:

Thomas Michael Loftus - Great Falls VA, US
Dorian Sergio Araneda - Lovettesville VA, US
James Robert Sherman - Penn Laird VA, US

Assignee:

Blackbird Technologies, Inc. - Herndon VA

International Classification:

G01C 21/30

US Classification:

701208, 701207, 701213, 34053913

Abstract:

A handheld device and system, in which such device and system include at least one mapping module, at least one tracking module interoperative with said at least one mapping module, at least one communications module interoperative with each of said at least one tracking module and said at least one mapping module, at least two antennae communicatively connected via said at least one communications module to at least one central processing unit, wherein at least one of said at least two antenna is suitable for communications using at least two distinct communication modes.

US Patent:

20040157918, Aug 12, 2004

Filed:

Oct 31, 2003

Appl. No.:

10/476513

Inventors:

Thomas Loftus - Great Falls VA, US
Craig Townsend - Baltimore MD, US
Gabriele Ronnett - Lutherville MD, US
M. Lane - Baltimore MD, US
Francis Kuhajda - Lutherville MD, US

International Classification:

A61K031/365

US Classification:

514/473000

Abstract:

This invention provides a method for inducing weight loss in an animal by administering to the animal a compound which reduces the expression and/or secretion of neuropeptide Y (NPY). The effect may be accomplished directly, indirectly or humorally. Preferably, administration of this compound has the effect of increasing malonyl CoA levels in the animal. Compounds administered according to this invention may be inhibitors of fatty acid synthase (FAS), including substituted -methylene--carboxyl--butyrolactones, or inhibitors of malonyl Coenzyme A decarboxylase (MCD). Preferably, the compound is administered in an amount sufficient to reduce the amount and/or duration of expression and/or secretion of NPY to levels at or below those observed for lean animals. In another preferred embodiment, the administration will reduce expression and/or secretion to levels observed for fed or satiated animals; more preferably, administration will reduce the level of NPY below that of fed animals. In a particular embodiment, this invention provides a method for inducing weight loss in an animal by administering a compound which inhibits feeding behavior in the animal. The method is particularly useful for inducing weight loss in animals deficient in expression of the hormone leptin or animals resistant to the action of leptin.

US Patent:

20070197638, Aug 23, 2007

Filed:

Jan 25, 2007

Appl. No.:

11/657536

Inventors:

Thomas Loftus - Great Falls VA, US
Craig Townsend - Baltimore MD, US
Gabrielle Ronnett - Lutherville MD, US
M. Lane - Baltimore MD, US
Francis Kuhajda - Lutherville MD, US

Assignee:

The Johns Hopkins University School of Medicine Licensing and Technology Development - Baltimore MD

International Classification:

A61K 31/365
C12Q 1/68

US Classification:

514473000, 435006000

Abstract:

This invention provides a method for inducing weight loss in an animal by administering to the animal a compound which reduces the expression and/or secretion of neuropeptide Y (NPY). The effect may be accomplished directly, indirectly, or humorally. Preferably, administration of this compound has the effect of increasing malonyl CoA levels in the animal. Compounds administered according to this invention may be inhibitors of fatty acid synthase (FAS), including substituted α-methylene-β-carboxyl-γ-butyrolactones, or inhibitors of malonyl Coenzyme A decarboxylase (MCD). Preferably, the compound is administered in an amount sufficient to reduce the amount and/or duration of expression and/or secretion of NPY to levels at or below those observed for lean animals. In another preferred embodiment, the administration will reduce expression and/or secretion to levels observed for fed or satiated animals; more preferably, administration will reduce the level of NPY below that of fed animals. In a particular embodiment, this invention provides a method for inducing weight loss in an animal by administering a compound which inhibits feeding behavior in the animal. The method is particularly useful for inducing weight loss in animals deficient in expression of the hormone leptin or animals resistant to the action of leptin.

US Patent:

20100022639, Jan 28, 2010

Filed:

Sep 11, 2009

Appl. No.:

12/558313

Inventors:

Thomas M. Loftus - Great Falls VA, US
Craig A. Townsend - Baltimore MD, US
Gabriele Ronnett - Lutherville MD, US
M. Daniel Lane - Baltimore MD, US
Francis P. Kuhajda - Lutherville MD, US

Assignee:

The Johns Hopkins University School of Medicine Licensing and Technology Development - Baltimore MD

International Classification:

A61K 31/365
C12Q 1/68
A61K 31/336

US Classification:

514473, 435 6, 514475

Abstract:

This invention provides a method for inducing weight loss in an animal by administering to the animal a compound which reduces the expression and/or secretion of neuropeptide Y (NPY). The effect may be accomplished directly, indirectly, or humorally. Preferably, administration of this compound has the effect of increasing malonyl CoA levels in the animal. Compounds administered according to this invention may be inhibitors of fatty acid synthase (FAS), including substituted α-methylene-β-carboxyl-γ-butyrolactones, or inhibitors of malonyl Coenzyme A decarboxylase (MCD). Preferably, the compound is administered in an amount sufficient to reduce the amount and/or duration of expression and/or secretion of NPY to levels at or below those observed for lean animals. In another preferred embodiment, the administration will reduce expression and/or secretion to levels observed for fed or satiated animals; more preferably, administration will reduce the level of NPY below that of fed animals. In a particular embodiment, this invention provides a method for inducing weight loss in an animal by administering a compound which inhibits feeding behavior in the animal. The method is particularly useful for inducing weight loss in animals deficient in expression of the hormone leptin or animals resistant to the action of leptin.

US Patent:

20120209504, Aug 16, 2012

Filed:

Jan 13, 2012

Appl. No.:

13/350330

Inventors:

Thomas Michael Loftus - Great Falls VA, US
Dorian Sergio Araneda - Lovettesville VA, US
James Robert Sherman - Penn Laird VA, US

Assignee:

Blackbird Technologies, Inc. - Herndon VA

International Classification:

G01C 21/30
G08B 1/08

US Classification:

701409, 34053913

Abstract:

A handheld device and system, in which such device and system include at least one mapping module, at least one tracking module interoperative with said at least one mapping module, at least one communications module interoperative with each of said at least one tracking module and said at least one mapping module, at least two antennae communicatively connected via said at least one communications module to at least one central processing unit, wherein at least one of said at least two antenna is suitable for communications using at least two distinct to communication modes.

US Patent:

20180321641, Nov 8, 2018

Filed:

Apr 30, 2018

Appl. No.:

15/967409

Inventors:

- Sunnyvale CA, US
Adam T. Black - Annandale VA, US
Thang Q. Tran - San Jose CA, US
Matthew D. Swallows - Santa Clara CA, US
Brian R. Patton - San Francisco CA, US
Miao Zhu - San Jose CA, US
Thomas H. Loftus - Arvada CO, US
Mark A. Kasevich - Palo Alto CA, US

International Classification:

G04F 5/14
H03L 7/26
H05H 3/02

Abstract:

An atomic oscillator device includes an atomic oscillator, a controlled oscillator, a resonance controller, and a cold-atom clock output. The atomic oscillator comprises a two-dimensional optical cooling region (2D OCR) for providing a source of atoms and a three-dimensional optical cooling region (3D OCR) for cooling and/or trapping the atoms emitted by the 2D OCR. The atomic oscillator comprises a microwave cavity surrounding the 3D OCR for exciting an atomic resonance. The controlled oscillator produces an output frequency. The resonance controller is for steering the output frequency of the controlled oscillator based on the output frequency and the atomic resonance as measured using an atomic resonance measurement. The cold-atom clock output is configured as being the output frequency of the controlled oscillator.