Thomas H Magee

US Patent:

8426374, Apr 23, 2013

Filed:

May 3, 2007

Appl. No.:

11/744158

Inventors:

Thomas R. Magee - Cypress CA, US
Monica G. Ferrini - Redondo Beach CA, US
Jacob Rajfer - Rolling Hills Estate CA, US

Assignee:

Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center - Torrance CA

International Classification:

A61K 48/00

US Classification:

514 44, 536 245, 536 2431, 536 241

Abstract:

A method comprising inhibiting myostatin expression or activity to increase muscle mass. Still further, methods for locally inhibiting myostatin expression or activity to reduce fibrosis are provided. The method comprises introducing a nucleotide sequence into a vector wherein the nucleotide sequence is expressed as a shRNA having a property to inhibit myostatin expression. The vector including the sequence may be delivered to a mammalian tissue. An electrical pulse may be applied across a point of delivery. A composition comprising a vector having a nucleotide sequence wherein the nucleotide sequence is expressed as a shRNA having a property to inhibit myostatin expression is further provided.