Thomas P Magee

US Patent:

8426374, Apr 23, 2013

Filed:

May 3, 2007

Appl. No.:

11/744158

Inventors:

Thomas R. Magee - Cypress CA, US
Monica G. Ferrini - Redondo Beach CA, US
Jacob Rajfer - Rolling Hills Estate CA, US

Assignee:

Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center - Torrance CA

International Classification:

A61K 48/00

US Classification:

514 44, 536 245, 536 2431, 536 241

Abstract:

A method comprising inhibiting myostatin expression or activity to increase muscle mass. Still further, methods for locally inhibiting myostatin expression or activity to reduce fibrosis are provided. The method comprises introducing a nucleotide sequence into a vector wherein the nucleotide sequence is expressed as a shRNA having a property to inhibit myostatin expression. The vector including the sequence may be delivered to a mammalian tissue. An electrical pulse may be applied across a point of delivery. A composition comprising a vector having a nucleotide sequence wherein the nucleotide sequence is expressed as a shRNA having a property to inhibit myostatin expression is further provided.

US Patent:

49767704, Dec 11, 1990

Filed:

Jun 29, 1989

Appl. No.:

7/373210

Inventors:

Keith D. Barnes - Newtown PA
Frederick W. Hotzman - Morrisville PA
Lawrence E. Limpel - Euclid OH
Thomas A. Magee - Mentor OH

Assignee:

Fermenta ASC Corporation - Mentor OH

International Classification:

A01N 4324

US Classification:

71 88

Abstract:

12H-dibenzo[d,g][1,3]dioxocin-6-carboxylic acid and certain derivatives thereof (glyoxylates) exhibit plant growth regulant and herbicidal activity when applied to a plant locus.