Thomas B Manning

US Patent:

20130004993, Jan 3, 2013

Filed:

Jun 28, 2011

Appl. No.:

13/170855

Inventors:

Thomas J. Manning - Hahira GA, US

Assignee:

University System of Georgia - Atlanta GA
Valdosta State University - Valdosta GA

International Classification:

C12P 21/00
C12N 1/26
C12N 1/14
C12N 1/12
C07D 305/14
C12P 17/18
C07D 515/22
C07K 1/14
C07D 493/22
C12P 17/02
C12N 1/20
C12N 1/22

US Classification:

435 712, 4352536, 435248, 4352568, 4352571, 435252, 435119, 540466, 435 711, 530344, 549344, 530321, 549267, 435123, 549510

Abstract:

Methods for producing and obtaining natural products from microbial amplification chambers are described. This approach utilizes the concept of green chemistry to synthesize and extract the marine and terrestrial natural products. The method describes techniques to colonize and grow the selected bacteria and to continuously harvest the pharmaceutical agent from the broth without using any commercial solvents.

US Patent:

20130237511, Sep 12, 2013

Filed:

Mar 12, 2012

Appl. No.:

13/418235

Inventors:

Thomas J. Manning - Hahira GA, US
Ryenne Nicole Ogburn - Valdosta GA, US
Kaitlyn Victoria Ledwitch - Valdosta GA, US
Dennis Ray Phillips - Nicholson GA, US
Gregory Page Wylie - Athens GA, US

Assignee:

University System of Georgia - Atlanta GA
Valdosta State University - Valdosta GA

International Classification:

A61K 31/555
A61P 35/00

US Classification:

514187, 514185

Abstract:

Methods for utilizing copper ions to bind to and help transport medicinal agents that contain a nitrogen atom or atoms are disclosed. The copper ion or ions serve as a delivery platform for a known pharmaceutical agent. The copper ions may be used to impact the polarity of the medicinal agents so they perform more efficiently in a physiological environment. The copper ions may also improve the efficacy of the drug by impacting their stability.

US Patent:

49681427, Nov 6, 1990

Filed:

Jun 2, 1989

Appl. No.:

7/360559

Inventors:

Thomas J. Manning - Gainesville FL
Byron A. Palmer - Los Alamos NM
Douglas E. Hof - Santa Fe NM

Assignee:

The United States of America as represented by the United States
Department of Energy - Washington DC

International Classification:

G01N 2173
G01N 3112
G01J 3443

US Classification:

356316

Abstract:

A closed inductively coupled plasma cell generates a relatively high power, low noise plasma for use in spectroscopic studies. A variety of gases can be selected to form the plasma to minimize spectroscopic interference and to provide a electron density and temperature range for the sample to be analyzed. Grounded conductors are placed at the tube ends and axially displaced from the inductive coil, whereby the resulting electromagnetic field acts to elongate the plasma in the tube. Sample materials can be injected in the plasma to be excited for spectroscopy.

US Patent:

60224568, Feb 8, 2000

Filed:

Feb 20, 1998

Appl. No.:

9/026835

Inventors:

Thomas J. Manning - Valdosta GA

Assignee:

Valdosta State University - Valdosta GA

International Classification:

B01J 1908

US Classification:

204176

Abstract:

A recirculating loop method for producing and/or using ozone is disclosed. The method comprises the steps of: supplying a gas mixture comprising oxygen and a catalyst, generating ozone from the gas mixture, and recirculating the gas mixture. In a preferred method, the method comprises the additional steps of: reacting the ozone with a chemically reactive species and adding sufficient oxygen to the oxygen and noble gas mixture to maintain the specific oxygen to noble gas ratio. Preferably, the ozone is generated by electrical discharge from oxygen and noble gas mixtures of a volume ratio of not greater than 9 to 1 oxygen to catalyst gas. The closed loop apparatus for generating ozone gas comprises: an electrical discharge chamber, a means for supplying oxygen to said electrical discharge chamber, a means for supplying a catalyst to said electrical discharge chamber, an application chamber connected to said electrical chamber, a means for supplying a chemically reactive species to said application chamber, a means for removing said chemically reactive species from said application chamber, a means for returning oxygen and the catalyst to said electrical discharge chamber.

US Patent:

20160135435, May 19, 2016

Filed:

Nov 13, 2014

Appl. No.:

14/540341

Inventors:

Thomas Manning - Hahira GA, US
Brittany Butler - Ray City GA, US
Mehulkumar Patel - Valdosta GA, US
Sydney Plummer - Quitman GA, US
Tess Baker - Valdosta GA, US

Assignee:

Valdosta State University, University System of Georgia - Valdosta GA

International Classification:

A01K 61/00

Abstract:

Many types of artificial reefs have been deployed in the world's oceans, bays and estuaries. These range from sinking ships to dispersing old building debris. In most approaches, the material placed in the marine environment lacks any nutrients needed for growth or concern regarding proper chemical conditions necessary to start and sustain life. In this discovery, concrete is made from both inorganic and organic components. The inorganic components are selected to include species that will be used to create a receptive surface to start and sustain life. Moreover, other conditions such as pH, chemical toxicity, nutrient levels and biodegradability are considered in the formulation. Additionally, there is an organic component that is part of the concentration mixture which provides trace nutrients and serves to weaken the structures so it will biodegrade over time. The biodegradable concrete slowly releases small quantities of resources (over months and years) providing a steady flux of essential nutrients.

US Patent:

20160038422, Feb 11, 2016

Filed:

Aug 3, 2015

Appl. No.:

14/816377

Inventors:

Thomas J. Manning - Hahira GA, US
Sydney E. B. Plummer - Quitman GA, US
Tess A. Baker - Valdosta GA, US

Assignee:

University System of Georgia, Valdosta State University - Valdosta GA

International Classification:

A61K 9/20
A61K 31/4409

Abstract:

Bacterial resistance to antibiotics is increasing worldwide creating a global threat. Tuberculosis (TB), caused by the bacterium , is a bacterial infectious disease that results in over one million deaths annually. The discovery outlined here involves a tablet composition for patient administration and subsequently a new paradigm in drug delivery vehicles in vivo and in vitro and is applied to existing TB antibiotics in order to increase their efficacy. The drug delivery system is a three component complex that is administered with the TB antibiotic or a combination of TB antibiotics. The components are a saccharide or saccharides, a transition metal ion or a combination of metal ions that can bind a nitrogen and/or oxygen atom(s), and a water soluble polymer capable of aggregating and enclosing the other constituents. The three component molecular delivery approach has demonstrated ability to overcome bacterial resistance to an existing antibiotic.

US Patent:

20150230434, Aug 20, 2015

Filed:

Feb 14, 2014

Appl. No.:

14/181606

Inventors:

Thomas J. Manning - Hahira GA, US

International Classification:

A01K 61/00

Abstract:

Artificial reefs serve a useful purpose to promote the growth of sessile marine organisms such as bacteria, algae, corals, and bryozoans as well as providing a habitat and food source for species such as fish, crabs, lobsters, and some marine invertebrates. This invention applies the United States Environmental Protection Agencies' Twelve Principles of Green Technology to provide a cellulose based surface that is coated in nutrients to promote the rapid growth of marine microbes, the base of the marine food chain. This rapid growth, which begins days after being submerged, starts the food chain. The mineral based substrate attached to the cellulose based material is denser than water to allow the entire structure to sink; both the cellulose and mineral based materials will degrade rapidly leaving behind nucleation sites for microbes, corals, invertebrate collections, and more. The reef is constructed entirely from biodegradable materials and production costs are economical.