Thomas P Mcclure

US Patent:

6379970, Apr 30, 2002

Filed:

Apr 30, 1999

Appl. No.:

09/302475

Inventors:

Daniel C. Liebler - Tucson AZ
Thomas D. McClure - Tucson AZ
Garth Powis - Tucson AZ

Assignee:

The Arizona Board of Regents on behalf of the University of Arizona - Tucson AZ

International Classification:

G01N 3300

US Classification:

436 86, 436 89, 436 16, 435 6, 435267, 435272, 435804, 536 187, 536 221, 536 231, 536 243, 536 2431, 536 2432, 536 2532, 536 254, 536 2541, 536 266, 204451, 204601, 204459, 204610

Abstract:

A method of detecting peptide fragments of protein(s) that are differentially present in biological samples. The identity of the peptides may be determined and correlated with the protein(s) that are differentially present in the samples.

US Patent:

7158862, Jan 2, 2007

Filed:

Jun 11, 2001

Appl. No.:

09/877182

Inventors:

Daniel C. Liebler - Tucson AZ, US
Beau T. Hansen - Tucson AZ, US
Daniel E. Mason - Tucson AZ, US
Sean W. Davey - Tucson AZ, US
Juliet A. Jones - Tucson AZ, US
Thomas McClure - Santee CA, US

Assignee:

The Arizona Board of Regents on Behalf of the University of Arizona - Tucson AZ

International Classification:

G06F 19/00
B01D 59/44
G01N 33/50

US Classification:

700266, 250281, 250282, 422 62, 436 86, 436 94, 436173, 700273, 702 19, 702 20, 702 22, 702 23, 702 27

Abstract:

A method, system, and computer program product for mining mass spectral data to detect chemical-specific characteristic features in large databases and/or files, including specifying spectral characteristics of mass spectra to mine, specifying a relationship between the spectral characteristics, searching the mass spectra for portions of the mass spectra which match the spectral characteristics based on the relationship, and assigning scores to the portions of mass spectra to indicate a degree of correlation between the portions of mass spectra and the spectral characteristics. Exemplary embodiments encompass a user specification of the spectral characteristics and their relationships used to mine the mass spectral data, automated specification of the spectral characteristics and their relationships used to mine the data, and real-time data mining wherein the mass spectrometer is adjusted based on the result.

US Patent:

44574533, Jul 3, 1984

Filed:

Oct 22, 1982

Appl. No.:

6/436087

Inventors:

Peter P. Stevens - Cochise AZ
Thomas R. McClure - Oakland CA
Ann H. Firstenfeld - Corte Madera CA

International Classification:

B65D 3700

US Classification:

222 48

Abstract:

A self-sealing container closure includes a rotatable cap mounted over the mouth of an oval squeezable container. The cap has an outlet opening defined by a valve seat. The outlet opening is sealed by a valve element forced against the valve seat by a valve spring and a pair of actuating arms. An upper end of each actuating arm is non-rotatably coupled to the cap while the lower end is connected to the valve spring. When the cap is rotated to align the actuating arms with the minimum width of the container, squeezing the sides of the container presses on the actuating arms to further deflect the valve spring. This forces the valve element away from the valve seat to open the container. Rotating the cap, to align the arms with the maximum width of the container, places the container in a non-operational mode. Also disclosed is a piston and cylinder arrangement coupled to the actuating arms for dispensing a measured amount of liquid from the container.