Thomas J Mcnicholas

US Patent:

20130035567, Feb 7, 2013

Filed:

Jul 31, 2012

Appl. No.:

13/562403

Inventors:

Michael S. Strano - Lexington MA, US
Paul W. Barone - Jamaica Plain MA, US
Jin-Ho Ahn - Seoul, KR
Kyungsuk Yum - Berkeley CA, US
Thomas P. McNicholas - Cambridge MA, US

International Classification:

A61B 5/1459
B82Y 15/00

US Classification:

600316, 977742, 977750

Abstract:

A composition for sensing an analyte can include a photoluminescent nanostructure complexed to a sensing polymer, where the sensing polymer includes an organic polymer non-covalently bound to the photoluminescent nanostructure and an analyte-binding protein covalently bound to the organic polymer, and where the analyte-binding protein is capable of selectively binding the analyte, and the analyte-binding protein undergoes a substantial conformational change when binding the analyte. Separately, a composition for sensing an analyte, can include a complex, where the complex includes a photoluminescent nanostructure in an aqueous surfactant dispersion and a boronic acid capable of selectively reacting with an analyte. The compositions can be used in devices and methods for sensing an analyte.

US Patent:

20150133752, May 14, 2015

Filed:

Sep 16, 2014

Appl. No.:

14/488040

Inventors:

- Cambridge MA, US
Michael S. Strano - Lexington MA, US
Nigel F. Reuel - Cambridge MA, US
Thomas P. McNicholas - Cambridge MA, US

International Classification:

A61B 5/1455
A61B 5/145
A61B 5/1459

US Classification:

600316, 600317, 427 74

Abstract:

A nanosensor for detecting an analyte can include a substrate, a photoluminescent nanostructure, and a polymer interacting with the photoluminescent nanostructure. The nanosensor can be used in in vivo for biomedical applications.

US Patent:

20140199229, Jul 17, 2014

Filed:

Mar 14, 2013

Appl. No.:

13/827478

Inventors:

- Cambridge MA, US
Thomas P. McNicholas - Cambridge MA, US
Andrew J. Hilmer - Cambridge MA, US
Rishabh M. Jain - Cambridge MA, US
Kevin C. Tvrdy - Cambridge MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C01B 31/02

US Classification:

4234472, 4234471

Abstract:

The present invention generally relates to compositions, methods, and systems for separating carbon-based nanostructures.