Thomas M Nguyen

US Patent:

57734208, Jun 30, 1998

Filed:

Oct 20, 1995

Appl. No.:

8/531142

Inventors:

Thomas T. Nguyen - Philadelphia PA
John W. Ellingboe - Ridgewood NJ

Assignee:

American Home Products Corporation - Madison NJ

International Classification:

A61K 3170
C07H 1700

US Classification:

514 25

Abstract:

This invention relates to acylated benzylglycosides and a method for their use as smooth muscle cell proliferation inhibitors and as therapeutic compositions for treating diseases and conditions which are characterize by excessive smooth muscle proliferation, such as restenosis. The acylated benzylglycosides of this invention are those of formula I, below: ##STR1## wherein X is ##STR2## R. sup. 1 is H, alkyl having 1 to 6 carbon atoms, chloro, bromo, or alkoxy having 1 to 6 carbon atoms; R. sup. 2 is H, an acyl group having 1 to 6 carbon atoms, phenylsulfonyl, or substituted phenylsulfonyl; and R. sup. 3 is an acyl group having 1 to 8 carbon atoms, benzoyl, substituted benzoyl, alkylsulfonyl having 1 to 6 carbon atoms, phenylsulfonyl, or substituted phenylsulfonyl; R. sup. 4, R. sup. 5, R. sup. 6, R. sup. 7, R. sup. 8, and R. sup. 9 are each, independently, an acyl group having 1 to 6 carbon atoms; and R. sup. 10 and R. sup. 11 are each, independently, an acyl group having 1 to 6 carbon atoms, or the R. sup. 10 and R. sup.

US Patent:

59771011, Nov 2, 1999

Filed:

Dec 20, 1996

Appl. No.:

8/505171

Inventors:

Fadia El-Fehail Ali - Cherry Hill NJ
William Bondinell - Wayne PA
William Francis Huffman - Malvern PA
M. Amparo Lago - Audubon PA
Richard McCulloch Keenan - Malvern PA
Chet Kwon - King of Prussia PA
William Henry Miller - Schwenksville PA
Thomas Nguyen - King of Prussia PA
Dennis T. Takata - Flourtown PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

A61K 3155
C07D40306
C07D40314

US Classification:

514221

Abstract:

Vitronectin receptor antagonists having the formula: ##STR1## which are useful for the treatment of inflammation, cancer and cardiovascular disorders, such as atherosclerosis and restenosis, and diseases wherein bone resorption is a factor, such as osteoporsis.