Thomas K O'Brien

US Patent:

7618783, Nov 17, 2009

Filed:

Apr 30, 2001

Appl. No.:

09/844281

Inventors:

Beverly Lynn Mangold - Rockville MD, US
Jennifer Lynn Aldrich - Silver Spring MD, US
Thomas W. O'Brien - Fairfax VA, US

Assignee:

Tetracore, Inc. - Rockville MD

International Classification:

G01N 33/53

US Classification:

435 71, 435 4, 435 72, 435 732, 435 772, 435975, 5303871, 5303881, 5303882, 5303884, 4241641

Abstract:

The present invention is directed to diagnostic tools and therapies using antibodies to Specifically, the present invention is directed to a -specific monoclonal antibody that binds to the EA1 antigen (corresponding to the eag gene) of the S-layer (surface layer) of spores. This monoclonal antibody may be used in a variety of applications, including to specifically detect and diagnose Preferably, antibodies are monoclonal and bind to a surface protein, such as EA1 protein, on the spores of and not to spores of either or Antibodies can be incorporated into detection kits using, for example, colloidal particle based lateral flow detection system. Such detection kits can distinguish anthrax spores from non-pathogenic varieties of spores. In addition, the invention is directed to EA1 antigen and pharmaceuticals such as vaccines that can be used as therapeutics and to develop improved antibodies and detection methods.

US Patent:

20060115908, Jun 1, 2006

Filed:

Nov 10, 2005

Appl. No.:

11/271040

Inventors:

Thomas O'Brien - Fairfax VA, US

Assignee:

TETRACORE, INC. - Rockville MD

International Classification:

G01N 33/551

US Classification:

436524000, 977920000

Abstract:

Air or gas is drawn into a particle impact collector where the air or gas is forced through non-linear passages inside the collector in such a manner that particles or droplets entrained in the air or gas, or contaminant vapors in the air or gas, are retained in and concentrated by the passages. Once retained and concentrated, the contaminants are suspended or dissolved in a liquid collection medium purging the passages, the collection medium containing assay reagents for a multiplexed binding assay. The agitation produced by the flow of gas and liquid through the non-linear passages increases the reaction rate of the assay.

US Patent:

20110200614, Aug 18, 2011

Filed:

Nov 16, 2009

Appl. No.:

12/619489

Inventors:

Beverly Lynn Mangold - Rockville MD, US
Jennifer Lynn Aldrich - Silver Spring MD, US
Thomas W. O'Brien - Fairfax VA, US

International Classification:

A61K 39/395
C12N 5/071
G01N 33/569
G01N 33/566
C07K 16/12
C12P 21/08
C07K 14/32
A61K 39/07
A61P 37/04
A61P 31/04

US Classification:

4241641, 435340, 435 71, 436501, 5303884, 435 7021, 5303879, 5303873, 5303895, 530350, 4242461

Abstract:

The present invention is directed to diagnostic tools and therapies using antibodies to . Specifically, the present invention is directed to a -specific monoclonal antibody that binds to the EA1 antigen (corresponding to the eag gene) of the S-layer (surface layer) of spores. This monoclonal antibody may be used in a variety of applications, including to specifically detect and diagnose . Preferably, antibodies are monoclonal and bind to a surface protein, such as EA1 protein, on the spores of , and not to spores of either or . Antibodies can be incorporated into detection kits using, for example, colloidal particle based lateral flow detection system. Such detection kits can distinguish anthrax spores from non-pathogenic varieties of spores. In addition, the invention is directed to EA1 antigen and pharmaceuticals such as vaccines that can be used as therapeutics and to develop improved antibodies and detection methods.

US Patent:

20210362164, Nov 25, 2021

Filed:

Aug 6, 2021

Appl. No.:

17/396545

Inventors:

- Ft. Detrick MD, US
Mark M. Bailey - Alexandria VA, US
Larry E. Bowen - Williamsport MD, US
Brett R. Haupt - Thurmont MD, US
Thomas J. O'Brien - Silver Spring MD, US

Assignee:

The Government of the United States, as Represented by the Secretary of the Army - Ft. Detrick MD

International Classification:

B04B 5/08
B01D 45/14
B04B 11/02

Abstract:

A system with a rotatable drum and an exposure device configured to age and concentrate aerosol particles by simulating operational conditions. The system includes the rotatable drum; a port connected to the drum, an impactor with vacuum nozzles, the exposure device, and optionally an outlet port when the port is solely an inlet port. The port delivers the aerosol particles into the drum with the nozzles withdrawing air to increase the concentration of the particles. After aging and concentrating, evacuating the aerosol particles directly from the drum into at least one of an exposure chamber or a testing apparatus.

US Patent:

20200292546, Sep 17, 2020

Filed:

Jan 24, 2020

Appl. No.:

16/752105

Inventors:

- Bethesda MD, US
Thomas R. O'BRIEN - Potomac MD, US
Brian MUCHMORE - Potomac MD, US
Raymond P. DONNELLY - Damascus MD, US
Patricia A. PORTER-GILL - Little Rock AR, US

International Classification:

G01N 33/569
C07K 14/555
C07K 16/24
C12Q 1/6883

Abstract:

The invention is related to identification of an interferon-analog (IFNL4) protein and genetic association with spontaneous clearance of HCV infection and response to treatment for HCV infection.

US Patent:

20180093281, Apr 5, 2018

Filed:

Oct 3, 2017

Appl. No.:

15/723448

Inventors:

- Ft. Detrick MD, US
Mark M. Bailey - Alexandria VA, US
Larry E. Bowen - Williamsport MD, US
Brett R. Haupt - Thurmont MD, US
Thomas J. O'Brien - Silver Spring MD, US

Assignee:

United States of America, as Represented by the Secretary of the Army - Ft. Detrick MD

International Classification:

B04B 5/08
B04B 11/02
B01D 45/14

Abstract:

An embodiment of the invention provides an aerosol concentrating apparatus for use with an aerosol aging drum, where the aerosol concentrating apparatus includes an outer housing, an aerosol inlet tube connected to the outer housing, and an extraction tube connected to the outer housing. An axle connected to the outer housing is axially centered within the outer housing, where the axle is formed from porous material. An inner housing is connected to the axle, such that the axle is axially centered within the inner housing, and such that the inner housing is adapted to spin about the axle within the outer housing to separate aerosol particles by size. Aerosol particles below a first threshold size are forced out of the aerosol concentrating apparatus through the axle; and, aerosol particles between the first threshold size and a second threshold size are suspended within the inner housing.

US Patent:

20170254808, Sep 7, 2017

Filed:

May 17, 2017

Appl. No.:

15/597459

Inventors:

- Bethesda MD, US
Thomas R. O'BRIEN - Potomac MD, US
Brian MUCHMORE - Potomac MD, US
Raymond P. DONNELLY - Damascus MD, US
Patricia A. PORTER-GILL - Little Rock AR, US

International Classification:

G01N 33/569
C07K 16/24
C12Q 1/68
C07K 14/555

Abstract:

The invention is related to identification of an interferon-analog (IFNL4) protein and genetic association with spontaneous clearance of HCV infection and response to treatment for HCV infection.

US Patent:

20150050640, Feb 19, 2015

Filed:

Mar 14, 2013

Appl. No.:

14/388293

Inventors:

- Bethesda MD, US
Thomas R. O'Brien - Potomac MD, US
Brian Muchmore - Potomac MD, US
Raymond P. Donnelly - Damascus MD, US
Patricia A. Porter-Gill - Little Rock AR, US

International Classification:

G01N 33/569
C07K 16/24
C07K 14/555

US Classification:

435 5, 530324, 530350, 5303879, 536 235, 4353201

Abstract:

The invention is related to identification of an interferon-analog (IFNL4) protein and genetic association with spontaneous clearance of HCV infection and response to treatment for HCV infection.