Thomas J Poole

US Patent:

20220369688, Nov 24, 2022

Filed:

May 5, 2022

Appl. No.:

17/737625

Inventors:

- London, GB
Alexandre Mendes CAMPOS - Porto Alegre, BR
Thomas H. POOLE - Winston-Salem NC, US
Christopher KELLER, JR. - Advance NC, US
Shahin ROOHINEJAD - Winston-Salem NC, US

International Classification:

A24B 13/00
A61K 9/00
A61K 31/465
A61K 47/38
A61K 47/12
A61K 47/02
A61K 45/06
A24B 15/16
A24B 15/40
A24B 15/32

Abstract:

The disclosure provides compositions configured for oral use, the compositions including at least one filler, water, a basic amine, and an organic acid, an alkali metal salt of an organic acid, or a combination thereof, wherein the organic acid has a log P value of from about 1.4 to about 8.0. At least a portion of the basic amine is associated with at least a portion of the organic acid or the alkali metal salt thereof. The association is in the form of a basic amine-organic acid salt, an ion pair between the basic amine and a conjugate base of the organic acid, or a combination of both. Further provided are methods for stabilizing a composition configured for oral use, for enhancing a predicted buccal absorption of a composition configured for oral use, and for reducing potential throat irritation associated with the use of compositions including a basic amine.

US Patent:

20220354785, Nov 10, 2022

Filed:

Apr 19, 2022

Appl. No.:

17/724056

Inventors:

- London, GB
Nicholas Von Cosmos - Moravian Falls NC, US
Matthew Lampe - Winston-Salem NC, US
Steven Lee Alderman - Lewisville NC, US
Thomas H. Poole - Winston-Salem NC, US
Michael Andrew Zawadzki - Clemmons NC, US
Charlotte Smith - Winston-Salem NC, US

International Classification:

A61K 9/00
A61K 47/10
A61K 47/12
A61K 31/465

Abstract:

Products configured for oral use and methods for preparing such products are provided. In particular, such products may be provided in the form of a lozenge. In some embodiments, oral products described herein may include a first sugar substitute in an amount of at least about 80 weight percent, a basic amine, and an organic acid, an alkali metal salt of an organic acid, or a combination thereof. In one or more embodiments, at least a portion of the basic amine is associated with at least a portion of the organic acid or the alkali metal salt thereof, the association in the form of a basic amine-organic acid salt, an ion pair between the basic amine and a conjugate base of the organic acid, or both.

US Patent:

20220346434, Nov 3, 2022

Filed:

Apr 22, 2022

Appl. No.:

17/727154

Inventors:

- London, GB
Nicolas Von Cosmos - Moravian Falls NC, US
Matthew E. Lampe - Winston-Salem NC, US
Steven Lee Alderman - Lewisville NC, US
Thomas H. Poole - Winston-Salem NC, US

International Classification:

A24B 15/16
A61K 9/00
A61K 47/26
A61K 47/42
A61K 31/465
A61K 47/12
A61K 47/10
A24B 13/00
A24B 15/40
A24B 15/32
A24B 15/30
A23G 3/42
A23G 3/38
A23G 3/36
A23G 3/54

Abstract:

An oral product configured for oral use is provided herein, the oral product including: at least one sugar substitute in an amount from about 25% to about 45% by weight, based on the total weight of the oral product; a gum in an amount from about 35% to about 55% by weight, based on the total weight of the oral product; a basic amine; and an organic acid, an alkali metal salt of an organic acid, or a combination thereof; wherein the organic acid has a log P value of from about 1.0 to about 12.0; wherein at least a portion of the basic amine is associated with at least a portion of the organic acid or the alkali metal salt thereof, the association in the form of a basic amine-organic acid salt, an ion pair between the basic amine and a conjugate base of the organic acid, or both; and wherein the oral product is in the form of a pastille.

US Patent:

20220346436, Nov 3, 2022

Filed:

Apr 21, 2022

Appl. No.:

17/726121

Inventors:

- London, GB
Steven Lee Alderman - Lewisville NC, US
Thomas H. Poole - Winston-Salem NC, US
Michael Joyce - Athens GA, US
Wesley Steven Jones - Lexington NC, US
Matthew Lampe - Winston-Salem NC, US

International Classification:

A24B 15/30
A61K 47/12
A61K 9/00
A61K 47/38
A61K 31/465

Abstract:

An oral product in the form of an edible film is provided herein. The edible film can include a binder in an amount of at least about 30 percent by weight; a plasticizer in an amount of at least about 5 percent by weight; and an active agent, wherein the edible film is orally dissolvable. The edible film can also be used as a component of another oral product, e.g., a fleece-based pouched product. The edible film can form a coating on a portion of an interior or exterior surface of a fleece-based pouched product.

US Patent:

20220304362, Sep 29, 2022

Filed:

Jun 9, 2022

Appl. No.:

17/836771

Inventors:

- London, GB
Thomas H. Poole - Winston-Salem NC, US
Dwayne William Beeson - Winston-Salem NC, US
Frank Kelley St. Charles - Bowling Green KY, US
Ronald K. Hutchens - East Bend NC, US

International Classification:

A24B 13/00
A24B 15/14
A24B 15/16
A24B 15/40
A24B 15/42
A61K 9/00
A61K 36/185
A61K 31/465

Abstract:

The disclosure provides compositions and products configured for oral use, the compositions and products including a filler material, an active ingredient, and a salt component. The salt component may be present in an amount of between about 3.0% and about 4.5% by weight based on the total weight of the composition. The compositions and products as described herein may particularly exhibit a desired flavor profile.

US Patent:

20220304363, Sep 29, 2022

Filed:

Jun 9, 2022

Appl. No.:

17/836823

Inventors:

- London, GB
Dwayne William Beeson - Kernersville NC, US
Ronald K. Hutchens - East Bend NC, US
Christopher Keller - Advance NC, US
Thomas H. Poole - Winston-Salem NC, US
Andries Don Sebastian - Kathleen GA, US
Frank Kelley St. Charles - Bowling Green KY, US

International Classification:

A24B 13/00
A24B 15/30
A24B 15/32
A24B 15/40
A24B 15/38

Abstract:

The disclosure provides for oral compositions that exhibit desired properties associated with moist products while incorporating a relatively low water content. Such compositions may include at least one releasable material, at least one filler/carrier component, and at least one water substitute, such as a polyol. The water substituted may be present in an amount of about 25% by weight or greater based on the total weight of the oral composition, and the compositions and products formed therewith can exhibit a relatively low water activity, such as in the range of about 0.85 or less. The present disclosure further provides methods of forming an oral composition with a mouthfeel corresponding to a moist product while having a relatively low water activity.

US Patent:

20220304365, Sep 29, 2022

Filed:

Jun 9, 2022

Appl. No.:

17/836794

Inventors:

- London, GB
Anthony Richard Gerardi - Winston-Salem NC, US
Ronald K. Hutchens - East Bend NC, US
Thomas H. Poole - Winston-Salem NC, US
Luis Mansalud - Kernersville NC, US
John Paul Mua - Advance NC, US
Frank Kelley St. Charles - Bowling Green KY, US

International Classification:

A24B 15/16
A24B 13/00
A24B 15/30
A24B 15/42
A24B 15/40
A61K 36/185
A61K 31/465
A61K 47/44
A61K 47/38
A61K 47/24

Abstract:

The disclosure provides a composition including a filler, a lipid having a melting point of about 29 C. or above, water, and a flavoring agent or an active ingredient or both a flavoring agent and an active ingredient, which is optionally substantially free of isomalt and substantially free of tobacco material, excluding any nicotine component present, based on the total weight of the composition. The disclosure also provides compositions including a filler, a lipid having a melting point of about 29 C. or above, water in an amount of at least about 15% by weight, based on total weight of the composition, and a flavoring agent or an active ingredient or both a flavoring agent and an active ingredient.

US Patent:

20220304366, Sep 29, 2022

Filed:

Jun 9, 2022

Appl. No.:

17/836814

Inventors:

- London, GB
Dwayne William Beeson - Kernersville NC, US
Ronald K. Hutchens - East Bend NC, US
Christopher Keller - Advance NC, US
Thomas H. Poole - Winston-Salem NC, US
Andries Don Sebastian - Kathleen GA, US
Frank Kelley St. Charles - Bowling Green KY, US

International Classification:

A24B 15/38
A24B 13/00
A24B 15/30

Abstract:

The disclosure provides products configured for oral use, the products including one or more agents adapted to or configured to reduce irritation that may be associated with release of a component from the products. Xylitol, in particular, may be useful as an irritation reducing agent. The disclosure further provides methods of reducing irritation associated with the release of one or more components from an oral composition or product.