Thomas Charles Robbins

US Patent:

20110238323, Sep 29, 2011

Filed:

May 14, 2010

Appl. No.:

13/132856

Inventors:

Thomas Charles Robbins - Salt Lake City UT, US
Robert Andrew Palais - Salt Lake City UT, US
Carl Thomas Wittwer - Salt Lake City UT, US

Assignee:

Idaho Technology, Inc. - Salt Lake City UT
The University of Utah Research Foundation - Salt Lake City UT

International Classification:

G06F 19/00
G01N 33/48

US Classification:

702 19, 702 32

Abstract:

An experimental melting curve is modeled as a sum of a true melting curve and background fluorescence. A deviation function may be generated based upon the experimental melting curve data and a model of a background signal. The deviation function may be generated by segmenting a range of the experimental curve into a plurality of windows. Within each window, a fit between the model of the background signal and the experimental melting curve data may be calculated. The deviation function may be formed from the resulting fit parameters. The deviation function may include background signal compensation and, as such, may be used in various melting curve analysis operations, such as data visualization, clustering, genotyping, scanning, negative sample removal, and the like. The deviation function may be used to seed an automated background correction process. A background-corrected melting curve may be further processed to remove an aggregation signal.

US Patent:

20210277450, Sep 9, 2021

Filed:

May 25, 2021

Appl. No.:

17/329844

Inventors:

- Salt Lake City UT, US
Robert John Crisp - Salt Lake City UT, US
Andrew Clinton Hemmert - Murray UT, US
Elizabeth Barker Campbell - Orem UT, US
Thomas Charles Robbins - Salt Lake City UT, US
David J. Eyre - Salt Lake City UT, US

International Classification:

C12Q 1/686
C12Q 1/6851
C12Q 1/689
C12Q 1/70

Abstract:

Methods and devices are provided for simultaneously amplifying a plurality of sample wells for a predetermined amount of amplification, detecting whether amplification has occurred in a first set of the wells, amplifying for an additional amount of amplification and detecting whether amplification has occurred in a second set of the wells. Methods are also provided for analyzing a target nucleic acid sequence using melt curves that were generated in a plurality of amplification cycles.

US Patent:

20210147924, May 20, 2021

Filed:

Jun 21, 2018

Appl. No.:

16/632823

Inventors:

- Salt Lake City UT, US
Thomas Charles Robbins - Salt Lake City UT, US
Charles Benjamin Cox - Sandy UT, US

International Classification:

C12Q 1/6848
G16B 30/00
C12Q 1/70
C12Q 1/689
C12Q 1/686

Abstract:

Methods, sample vessels, and instruments are provided for melting curve analysis.

US Patent:

20200164334, May 28, 2020

Filed:

Oct 11, 2019

Appl. No.:

16/599352

Inventors:

- Salt Lake City UT, US
Kirk Max Ririe - Salt Lake City UT, US
Thomas Charles Robbins - Salt Lake City UT, US
Elizabeth Doman Copene - Salt Lake City UT, US
Charles Benjamin Cox - Sandy UT, US

International Classification:

B01J 19/00
B01L 3/02

Abstract:

Devices and methods are provided for spotting an array with fluid. Arrays produced by such methods are also provided. In one aspect of the invention, a spotter device for spotting a plurality of fluids into an array is described, the spotter device comprising a plurality of reservoirs provided in a first configuration, each reservoir holding its respective fluid, a print head having a plurality of positions provided in a second configuration, the second configuration being different from the first configuration, a plurality of tubes, each tube configured to provide fluid communication from a reservoir at a first end of the tube to a position in the print head at the second end of the tube, and a pump for pumping fluid through the tubes from the reservoir to the print head.

US Patent:

20180320220, Nov 8, 2018

Filed:

Jul 17, 2018

Appl. No.:

16/037948

Inventors:

- Salt Lake City UT, US
Robert John Crisp - Salt Lake City UT, US
Andrew Clinton Hemmert - Murray UT, US
Elizabeth Barker Campbell - Orem UT, US
Thomas Charles Robbins - Salt Lake City UT, US
David J. Eyre - Salt Lake City UT, US

International Classification:

C12Q 1/686

Abstract:

Methods and devices are provided for simultaneously amplifying a plurality of sample wells for a predetermined amount of amplification, detecting whether amplification has occurred in a first set of the wells, amplifying for an additional amount of amplification and detecting whether amplification has occurred in a second set of the wells. Methods are also provided for analyzing a target nucleic acid sequence using melt curves that were generated in a plurality of amplification cycles.

US Patent:

20170209844, Jul 27, 2017

Filed:

Jan 5, 2017

Appl. No.:

15/399663

Inventors:

- Salt Lake City UT, US
Kirk Max Ririe - Salt Lake City UT, US
Thomas Charles Robbins - Salt Lake City UT, US
Elizabeth Doman Copene - Salt Lake City UT, US
Charles Benjamin Cox - Sandy UT, US

International Classification:

B01J 19/00

Abstract:

Devices and methods are provided for spotting an array with fluid. Arrays produced by such methods are also provided. In one aspect of the invention, a spotter device for spotting a plurality of fluids into an array is described, the spotter device comprising a plurality of reservoirs provided in a first configuration, each reservoir holding its respective fluid, a print head having a plurality of positions provided in a second configuration, the second configuration being different from the first configuration, a plurality of tubes, each tube configured to provide fluid communication from a reservoir at a first end of the tube to a position in the print head at the second end of the tube, and a pump for pumping fluid through the tubes from the reservoir to the print head.

US Patent:

20150283531, Oct 8, 2015

Filed:

Apr 17, 2013

Appl. No.:

14/395002

Inventors:

- Salt Lake City UT, US
Kirk Max Ririe - Salt Lake City UT, US
Thomas Charles Robbins - Salt Lake City UT, US
Elizabeth Doman Copene - Salt Lake City UT, US
Charles Benjamin Cox - Sandy UT, US

International Classification:

B01J 19/00

Abstract:

Devices and methods are provided for spotting an array with fluid. Arrays produced by such methods are also provided. In one aspect of the invention, a spotter device for spotting a plurality of fluids into an array is described, the spotter device comprising a plurality of reservoirs provided in a first configuration, each reservoir holding its respective fluid, a print head having a plurality of positions provided in a second configuration, the second configuration being different from the first configuration, a plurality of tubes, each tube configured to provide fluid communication from a reservoir at a first end of the tube to a position in the print head at the second end of the tube, and a pump for pumping fluid through the tubes from the reservoir to the print head.

US Patent:

20150232916, Aug 20, 2015

Filed:

Sep 9, 2013

Appl. No.:

14/425588

Inventors:

- Salt Lake City UT, US
Robert John Crisp - Salt Lake City UT, US
Andrew Clinton Hemmert - Murray UT, US
Elizabeth Barker Campbell - Orem UT, US
Thomas Charles Robbins - Salt Lake City UT, US
David J. Eyre - Salt Lake City UT, US

International Classification:

C12Q 1/68

Abstract:

Methods and devices are provided for simultaneously amplifying a plurality of sample wells for a predetermined amount of amplification, detecting whether amplification has occurred in a first set of the wells, amplifying for an additional amount of amplification and detecting whether amplification has occurred in a second set of the wells. Methods are also provided for analyzing a target nucleic acid sequence using melt curves that were generated in a plurality of amplification cycles.