Thomas E. Rollins - North Plainfield NJ Martin S. Springer - Westfield NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07K 1508 C07K 1514
US Classification:
530350
Abstract:
A method is disclosed for isolating and purifying C5a receptor from human polymorphonuclear leukocytes. C5a is a complement-derived protein which is important as a mediator of inflammatory responses. C5a receptor may be used to screen create and quantify C5a antagonists useful as anti-inflammatory agents and immunoregulants and to generate monoclonal and polyclonal anti-C5a receptor antibodies useful as anti-inflammatory agents and immunoregulants.