Thomas S Rowe

US Patent:

6627618, Sep 30, 2003

Filed:

Jan 5, 2001

Appl. No.:

09/755681

Inventors:

Volkmar Weissig - Allston MA
Jeffrey Allen Hughes - Gainesville FL
Jürgen Lasch - Halle, DE
Thomas Cardon Rowe - Gainesville FL

Assignee:

University of Florida Research Foundation, Inc. - Gainesville FL

International Classification:

A61K 4800

US Classification:

514 44, 4353201, 435455, 435458, 424450

Abstract:

The subject invention finds utility in the area of gene therapy of diseases. More specifically, the invention concerns the making of a novel non-viral vector which can bind to desired DNA to form a combination useful to transfect diseased mitochondria of human or animal cells. The non-viral vector comprises a dequalinium salt subjected to standard liposome production procedures to obtain the vector named DQAsomes.

US Patent:

20070208058, Sep 6, 2007

Filed:

Mar 21, 2007

Appl. No.:

11/689091

Inventors:

Roy Bryant - Dahlonega GA, US
Ravi Parihar - Atlanta GA, US
Thomas Rowe - Roswell GA, US

International Classification:

A61K 31/453
A61K 31/4164

US Classification:

514324000, 514401000

Abstract:

Stable compositions comprising ketotifen or a ketotifen salt and methods of preparing such compositions are provided. The pH of the compositions remains at less than about 5 during storage. The methods comprise preparing pharmaceutical compositions comprising ketotifen or a ketotifen salt, and adjusting their pH to less than 5, thus slowing the changes of the active ingredients.

US Patent:

20110312998, Dec 22, 2011

Filed:

Aug 26, 2011

Appl. No.:

13/218694

Inventors:

Roy W. Bryant - Dahlonega GA, US
Ravi Parihar - Atlanta GA, US
Thomas Rowe - Roswell GA, US
Susan Caballa - Sugar Hill GA, US

International Classification:

A61K 31/4535
A61P 27/02

US Classification:

514324

Abstract:

Stable compositions comprising ketotifen or a ketotifen salt and methods of preparing such compositions are provided. The pH of the compositions remains at less than about 5 during storage. The methods comprise preparing pharmaceutical compositions comprising ketotifen or a ketotifen salt, and adjusting their pH to less than 5, thus slowing the changes of the active ingredients.

US Patent:

20120164213, Jun 28, 2012

Filed:

Jun 18, 2010

Appl. No.:

13/378335

Inventors:

Clive H. Reading - Kent, GB
Thomas Rowe - Roswell GA, US
Mario G. Fsadni - Hertfordshire, GB
Rick Coulon - Cummings GA, US

Assignee:

Altos Vision Limited - Kent

International Classification:

A61K 9/127
A61P 27/02
A61P 29/00
A61K 31/56

US Classification:

424450, 514170, 514171, 514182

Abstract:

A topical application formulation of estrogen and estrogen analogs or other estrogen receptor modulators is disclosed for the treatment of primary or secondary dry eye syndrome (also known as keratoconjunctivitis sicca (KCS)). Preferred formulations include 17-β-estradiol and its derivatives in lipid, liposomes, polymers, or aqueous or non-aqueous vehicles for the topical treatment of the ocular surface tissues particularly as time-release or micro-dose formulations. These formulations may also be useful in treating other conditions where KCS may occur, such as post-operative refractive surgery and corneal transplant patients.

US Patent:

56114648, Mar 18, 1997

Filed:

May 30, 1995

Appl. No.:

8/449476

Inventors:

Stephen M. Martin - Roswell GA
Harold Shlevin - Marietta GA
Thomas E. Rowe - Roswell GA

Assignee:

CIBA Geigy Corporation - Tarrytown NY

International Classification:

B67D 558

US Classification:

22218906

Abstract:

A container, composition and method for preserving treatment solutions, in which the composition includes weak and strong preservatives. The dispensing container includes media within a dispensing tip which media removes or alters the strong preservative, while allowing the weak preservative to inhibit microbial growth in the tip media. The dispensing container is especially useful in delivering to the ocular environment ophthalmic solutions which are essentially free of strong preservative which may cause patient discomfort. A dispensing container including a pH-preserved pilocarpine solution is disclosed in one embodiment.

US Patent:

61718637, Jan 9, 2001

Filed:

Sep 8, 1998

Appl. No.:

9/148953

Inventors:

Volkmar Weissig - Allston MA
Jeffrey Allen Hughes - Gainesville FL
Jurgen Lasch - Halle, DE
Thomas Cardon Rowe - Gainesville FL

Assignee:

University of Florida - Gainesville FL

International Classification:

C12N 1588

US Classification:

435458

Abstract:

The subject invention finds utility in the area of gene therapy of diseases. More specifically, the invention concerns the making of a novel non-viral vector which can bind to desired DNA to form a combination useful to transfect diseased mitochondria of human or animal cells. The non-viral vector comprises a dequalinium salt subjected to standard liposome production procedures to obtain the vector names DQAsomes.

US Patent:

58635629, Jan 26, 1999

Filed:

Mar 29, 1996

Appl. No.:

8/626198

Inventors:

Stephen Merritt Martin - Roswell GA
Harold Shlevin - Marietta GA
Thomas Edward Rowe - Roswell GA

Assignee:

CIBA Vision Corporation - Duluth GA

International Classification:

A61K 3340

US Classification:

424616

Abstract:

A container, composition and method for preserving treatment solutions, in which the composition includes weak and strong preservatives. The dispensing container includes media within a dispensing tip which media removes or alters the strong preservative, while allowing the weak preservative to inhibit microbial growth in the tip media. The dispensing container is especially useful in delivering to the ocular environment ophthalmic solutions which are essentially free of strong preservative which may cause patient discomfort. A dispensing container including a pH-preserved pilocarpine solution is disclosed in one embodiment.

US Patent:

60906197, Jul 18, 2000

Filed:

Sep 8, 1997

Appl. No.:

8/929175

Inventors:

Volkmar Weissig - Allston MA
Jeffrey Allen Hughes - Gainesville FL
Jurgen Lasch - Halle, DE
Thomas Cardon Rowe - Gainesville FL

Assignee:

University of Florida - Gainesville FL

International Classification:

C12N 1500
A61K 4800

US Classification:

4353201

Abstract:

The subject invention finds utility in the area of gene therapy of diseases. More specifically, the invention concerns the making of a novel non-viral vector which can bind to desired DNA to form a combination useful to transfect diseased mitochondria of human or animal cells. The non-viral vector comprises a dequalinium salt subjected to standard liposome production procedures to obtain the vector named DQAsomes.