Thomas D Schmittgen

US Patent:

20100286232, Nov 11, 2010

Filed:

Mar 2, 2007

Appl. No.:

12/281194

Inventors:

Thomas D. Schmittgen - Granville OH, US
Daniel J. Brackett - Seminole OK, US

Assignee:

The Ohio State University - Columbus OH

International Classification:

A61K 31/7088
C12Q 1/68
C40B 30/04
A61P 35/04

US Classification:

514 44 A, 435 6, 506 9, 514 44 R

Abstract:

Methods are provided for diagnosing whether a subject has, or is at risk of developing, pancreatic cancer. The methods include measuring the level of at least one miR gene product in a biological sample derived from the subject's pancreas. An alteration in the level of the miR gene product in the biological sample as compared to the level of a corresponding miR gene product in a control sample, is indicative of the subject either having, or being at risk for developing, pancreatic cancer.

US Patent:

20110171646, Jul 14, 2011

Filed:

Dec 7, 2010

Appl. No.:

12/962065

Inventors:

Thomas D. Schmittgen - Granville OH, US
Daniel J. Brackett - Seminole OK, US

Assignee:

The Ohio State University Research Foundation - Columbus OH
Board of Regents of the University of Oklahoma - Norman OK

International Classification:

C12Q 1/68

US Classification:

435 611, 435 614, 435 613

Abstract:

Methods are provided for diagnosing whether a subject has, or is at risk of developing, pancreatic cancer. The methods include measuring the level of at least one miR gene product in a biological sample derived from the subject's pancreas. An alteration in the level of the miR gene product in the biological sample as compared to the level of a corresponding miR gene product in a control sample, is indicative of the subject either having, or being at risk for developing, pancreatic cancer

US Patent:

8192938, Jun 5, 2012

Filed:

Feb 24, 2006

Appl. No.:

11/816767

Inventors:

Thomas D. Schmittgen - Granville OH, US

Assignee:

The Ohio State University - Columbus OH

International Classification:

C12Q 1/68
C12P 19/34

US Classification:

435 612, 435 912

Abstract:

The present invention is directed to methods, reagents, kits and compositions for detecting microRNA (miRNA) precursors in a biological sample. The methods uses gene-specific primers and reverse transciptase to convert the primary miRNA precursors (pri-miRNA) and pre-miRNA precursors (pre-miRNAs) to cDNA. The method also uses amplification reactions using gene specific forward and reverse primers that are targeted to the hairpin sequence of pri- and pre-microRNA precursors to detect the expression levels of both the pri- and the pre-microRNAs.