Business Law Corporate Counsel Corporate Governance Financial Services Franchise & Distribution Law Mergers and Acquisitions Real Property Law Securities Insurance Law Insolvency
Richard A Keith - Wilmington DE Edward J Warawa - Wilmington DE Thomas R Simpson - Wilmington DE
Assignee:
Astrazenela UK Limited
International Classification:
A61K 3155
US Classification:
514218, 540575
Abstract:
This invention provides substituted 1,2,3,4-tetrahydronaphthalene [ H]-emopamil binding site inhibitors useful in the treatment of neurological disorders. Such inhibitors are compounds of formula (I) wherein R, R1, m, R2 and n are as defined in the specification. The invention also provides pharmaceutical compositions containing such compounds, methods of using such compounds and methods of making such compounds.
Christopher Becker - Wilmington DE, US Bruce Dembofsky - Wilmington DE, US Robert Jacobs - Wilmington DE, US James Kang - Wilmington DE, US Cyrus Ohnmacht - Wilmington DE, US James Rosamond - Wilmington DE, US Ashokkumar Bhikkappa Shenvi - Wilmington DE, US Thomas Simpson - Wilmington DE, US James Woods - Wilmington DE, US
Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid β protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit γ secretase and thereby inhibit the production of amyloid β protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.
Keith John Herzog - Wilmington DE, US Robert Jacobs - Research Triangle Park NC, US Jianxing Kang - Wilmington DE, US Thomas Richard Simpson - Wilmington DE, US James M Woods - Wilmington DE, US
This invention relates to novel compounds having formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit secretase and thereby inhibit the production of amyloid β protein, thereby acting to prevent the formation of neurological deposits of amyloid protein. The present invention relates to the treatment of neurological disorders related to amyloid β-protein production such as Alzheimer's disease.
Thomas R. Simpson - West Chester PA, US James Kang - Chadds Ford PA, US Jeffrey S. Albert - Wilmington DE, US Cristobal Alhambra - Havertown PA, US Gerald M. Koether - Bear DE, US James Woods - Wilmington DE, US Yan Li - Glen Mills PA, US
Hui-Fang Chang - Wilmington DE, US Christopher Holmquist - Wilmington DE, US Eifion Phillips - Boothwyn PA, US Timothy Piser - Wilmington DE, US Thomas Simpson - Wilmington DE, US Rebecca Urbanek - Wilmington DE, US James Woods - Wilmington DE, US Hui Xiong - Wilmington DE, US
Assignee:
AstraZeneca AB
International Classification:
C07D 265/30 A61K 31/5375
US Classification:
544106, 546 18, 5142312, 514278
Abstract:
Nicotinic acetylcholine receptor ligands of Formula I.
Alkyl Sulfoxide Quinolines As Nk-3 Receptor Ligands
Jeffrey S. Albert - Wilmington DE, US Gerard M. Koether - Wilmington DE, US Cristobal Alhambra - Wilmington DE, US James Kang - Wilmington DE, US Thomas R. Simpson - Wilmington DE, US James Woods - Wilmington DE, US Yan Li - Wilmington DE, US
Thomas Simpson - Wilmington DE, US James Kang - Wilmington DE, US Jeffrey Albert - Wilmington DE, US Cristobal Alhambra - Wilmington DE, US Gerard Koether - Wilmington DE, US James Woods - Wilmington DE, US Yan Li - Wilmington DE, US
Christopher Becker - Wilmington DE, US Jeanne Comstock - West Boylston MA, US William Michne - Wilmington DE, US Megan Murphy - Wilmington DE, US Eifion Phillips - Wilmington DE, US James Rosamond - Wilmington DE, US Thomas Simpson - Wilmington DE, US
International Classification:
A61K 31/4743 A61K 31/4741 A61K 31/473
US Classification:
514290000, 514291000
Abstract:
Compounds of Formula I or Formula II wherein R, X and Ar are as described in the specification, pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially for treatment of conditions associated with reductions in nicotinic transmission.
Isbn (Books And Publications)
Dios, El Mamboreta Y La Mosca: Investigaciones De Un Hombre Curioso
23321 E Knox Ave, Liberty Lake, WA 99019 PO Box 665, Liberty Lake, WA 99019 22425 E Appleway Ave FL 1, Liberty Lake, WA 99019 2394 E Camelback Rd, Phoenix, AZ 85016 5099266000, 5099268915, 8005514567
Thomas Daniel Simpson Managing
Iqon Hospitality, LLC
Thomas H. Simpson Manager
MUDDY TOES, LLC
Thomas Simpson Director of Data Processing
Dmb Associates, Inc Ret Misc Merchandise Nonresdentl Bldg Operatr Ret Mail-Order House Nonresidential Cnstn Mfg Architectural Mtlwrk · Ret Misc Merchandise Ret Mail-Order House Mfg Architectural Mtlwrk Nonresidential Cnstn Nonresdentl Bldg Operatr
7600 E Doubletree, Scottsdale, AZ 85258 4803677000
Thomas S. Simpson Director, Secretary
Buske Lines, Inc
Thomas S. Simpson Secretary
TMS-CBS RPG, LLC Nonclassifiable Establishments
8201 N Hayden Rd, Scottsdale, AZ 85258 500 W Madison St SUITE 2400, Chicago, IL 60661 124 W Capitol Ave SUITE 1900, Little Rock, AR 72201 1000 N Old Rte 66, Litchfield, IL 62056
helper at Carney Electric, Referee at Charlotte Hockey Officiating Program (CHOP), Concessions Manager/ ID Check at Wolfgang Puck Catering, Concessions Manager for Uptown Amp at Wolfgang Puck Catering
Location:
Charlotte, North Carolina
Industry:
Entertainment
Work:
Carney Electric since Sep 2011
helper
Charlotte Hockey Officiating Program (CHOP) since Nov 2010
Referee
Wolfgang Puck Catering since Aug 2009
Concessions Manager/ ID Check
Wolfgang Puck Catering since Aug 2008
Concessions Manager for Uptown Amp
Ovations Food Service Mar 2011 - Sep 2011
Level Supervisor
Education:
Johnson and Wales University 2006 - 2011
Bachelor of Science; Entertainment, Sports; Event Management
Aquinas Instititute of Rochester 2002 - 2006
Principal Owner at The Kent Stage, Exec. Director at Western Reserve Folk Arts Assoc.
Location:
Kent, Ohio
Industry:
Entertainment
Work:
The Kent Stage - Cleveland/Akron, Ohio Area since Feb 2002
Principal Owner
Western Reserve Folk Arts Assoc. - Kent, Ohio since Aug 1998
Exec. Director
Main Street Kent 2007 - 2009
Board Member
Education:
Kent State University
Bachelor of Science (BS), General Studies
Skills:
Entertainment Music Music Industry Recording Voice Over Event Planning Event Management Talent Booking Sound Festivals Theatre Studio Recording Production Managment
Harbin ClinicHarbin Clinic Medical Oncology 255 W 5 St SW FL 2, Rome, GA 30165 7065289110 (phone), 7065289113 (fax)
Education:
Medical School University of Alabama School of Medicine Graduated: 1984
Procedures:
Chemotherapy Bone Marrow Biopsy
Conditions:
Anemia Bladder Cancer Breast Neoplasm, Malignant Cervical Cancer Gastric Cancer
Languages:
English Spanish
Description:
Dr. Simpson graduated from the University of Alabama School of Medicine in 1984. He works in Rome, GA and 1 other location and specializes in Hematology/Oncology. Dr. Simpson is affiliated with Cartersville Medical Center, Floyd Medical Center and Redmond Regional Medical Center.
Thomas E Simpson MD 124 W 32 St, Bayonne, NJ 07002 2013392332 (phone), 2013392465 (fax)
Education:
Medical School New York University School of Medicine Graduated: 1976
Procedures:
Appendectomy Bariatric Surgery Breast Biopsy Endoscopic Retrograde Cholangiopancreatography (ERCP) Gallbladder Removal Hallux Valgus Repair Hemorrhoid Procedures Hernia Repair Laparoscopic Gallbladder Removal Mastectomy Proctosigmoidoscopy Sigmoidoscopy Small Bowel Resection Thoracoscopy Tracheostomy Upper Gastrointestinal Endoscopy Laparoscopic Appendectomy Oophorectomy Pilonidal Cyst Excision
Conditions:
Hemorrhoids Abdominal Hernia Appendicitis Breast Disorders Cholelethiasis or Cholecystitis
Languages:
English
Description:
Dr. Simpson graduated from the New York University School of Medicine in 1976. He works in Bayonne, NJ and specializes in General Surgery. Dr. Simpson is affiliated with Carepoint Health Bayonne Medical Center, Carepoint Hoboken University Medical Center, Christ Hospital and Jersey City Medical Center.
Otologic Medical Services PCEar Nose & Throat Medical Services PC 2615 Northgate Dr, Iowa City, IA 52245 3193515680 (phone), 3193518980 (fax)
Education:
Medical School University of Iowa Carver College of Medicine Graduated: 1990
Procedures:
Allergen Immunotherapy Allergy Testing Hearing Evaluation Inner Ear Tests Myringotomy and Tympanotomy Rhinoplasty Sinus Surgery Skin Tags Removal Skull/Facial Bone Fractures and Dislocations Sleep and EEG Testing Tonsillectomy or Adenoidectomy Tracheostomy Tympanoplasty Vaccine Administration
Conditions:
Hearing Loss Abdominal Hernia Acne Acute Bronchitis Acute Pharyngitis
Languages:
English
Description:
Dr. Simpson graduated from the University of Iowa Carver College of Medicine in 1990. He works in Iowa City, IA and specializes in Otolaryngology. Dr. Simpson is affiliated with Mercy Hospital.
Pioneer Family Medicine Of Rural Hall 100 E Wall St, Rural Hall, NC 27045 3369699158 (phone), 3369694554 (fax)
Thomas Edward Simpson MD 3001 Maplewood Ave STE 301, Winston Salem, NC 27103 3367682403 (phone), 3364504020 (fax)
Education:
Medical School Wake Forest University School of Medicine Graduated: 1957
Languages:
English
Description:
Dr. Simpson graduated from the Wake Forest University School of Medicine in 1957. He works in Winston-Salem, NC and 1 other location and specializes in General Surgery. Dr. Simpson is affiliated with Pioneer Community Hospital Of Stokes.
Marshfield ClinicMarshfield Clinic Minocqua Center 9601 Townline Rd, Minocqua, WI 54548 7153581000 (phone), 7153581156 (fax)
Education:
Medical School Dalhousie Univ, Fac of Med, Halifax, Ns, Canada Graduated: 1978
Languages:
English
Description:
Dr. Simpson graduated from the Dalhousie Univ, Fac of Med, Halifax, Ns, Canada in 1978. He works in Minocqua, WI and specializes in Anesthesiology. Dr. Simpson is affiliated with Howard Young Medical Center.
San Francisco, CAThomas Robert Simpson, actor, director, producer, and writer, is the founder and artistic director of AfroSolo Arts Festival. Since 1991 he has concentrated on... Thomas Robert Simpson, actor, director, producer, and writer, is the founder and artistic director of AfroSolo Arts Festival. Since 1991 he has concentrated on presenting African American and African Diasporan art and culture through solo performances and the visual and literary arts.
For the past...
Santa Clara University - Bachelor of Arts, Santa Clara University - Juris Doctorate
Tagline:
Skilled and Experienced Divorce Lawyer in Glendale
Thomas Simpson
Work:
ZipNac - Guide/Wall Manager (2012)
About:
Hello, I'm a climber with 3+ years of experience under my harness, and a bouldering enthusiast. I am also currently working to get a climbing holds manufacturing company off the ground. As a sole-...
Tagline:
Climber.
Thomas Simpson
Education:
Mantachie Attendance Center
About:
My name is Thomas but most people know me as T.C. I am also an eagle scout, band member, and a gentleman.
Among those in the Sanders crowd, Thomas Simpson, a 29-year-old nonprofit worker from Allston, Massachusetts, said he originally supported Warren but switched and voted for Sanders during the early-voting period after her struggles in Iowa, New Hampshire and Nevada.
Date: Feb 29, 2020
Category: Headlines
Source: Google
Youtube
Thomas the Tank Engine References in The Simp...
Comment any ideas for future videos below Also Check Out My second Cha...
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Two pieces from a Renaissance English dance suite.
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The Story of Tom Simpson Part 4/6
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The Story of Tom Simpson Part 1/6
The Story of English Cyclist Tom Simpson and his death on Mt. Ventoux ...
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The Story of Tom Simpson Part 6/6
The Story of English Cyclist Tom Simpson and his death on Mt. Ventoux ...
Duration:
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Bought with a Price
Provided to YouTube by CDBaby Bought with a Price Thomas Simpson Boug...