Thomas Vernice Spring

US Patent:

7256008, Aug 14, 2007

Filed:

Jan 6, 2006

Appl. No.:

11/327711

Inventors:

Thomas G. Spring - Highland Park IL, US
Elaine M. Brate - Grayslake IL, US
Rajarathnam E. Reddy - Gurnee IL, US
Donald D. Johnson - Lindenhurst IL, US
You Pan - Libertyville IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

G01N 33/00

US Classification:

435 793, 435 71, 435 792, 436518, 436524

Abstract:

Methods and kits for measurement of concentration of FK778 in a biological sample by means of an immunoassay, preferably a competitive immunoassay. In one aspect, the method and kit involve the use of (a) an antibody to FK778 conjugated to a label, e. g. , an acridinium label, (b) an antibody to FK778 not conjugated to a label, (c) a solid phase containing an antibody to a first hapten, e. g. , a fluorescein hapten, and (d) a bihapten comprising a first hapten and FK778 or an analogue of FK778, e. g. , a bihapten comprising a fluorescein hapten and a FK778 hapten. In another aspect, the method and kit involve the use of (a) antibody to FK778, (b) a bihapten comprising FK778 or an analogue of FK778 and a first hapten, e. g. , a bihapten comprising the fluorescein hapten and the hapten of FK778 or an analogue of FK778, and (c) a pretreatment reagent.

US Patent:

20070243631, Oct 18, 2007

Filed:

Jun 29, 2007

Appl. No.:

11/770853

Inventors:

Thomas Spring - Highland Park IL, US
Elaine Brate - Grayslake IL, US
Rajarathnam Reddy - Gurnee IL, US
Donald Johnson - Lindenhurst IL, US
You Pan - Libertyville IL, US

International Classification:

G01N 33/566

US Classification:

436501000

Abstract:

Methods and kits for measurement of concentration of FK778 in a biological sample by means of an immunoassay, preferably a competitive immunoassay. In one aspect, the method and kit involve the use of (a) an antibody to FK778 conjugated to a label, e.g., an acridinium label, (b) an antibody to FK778 not conjugated to a label, (c) a solid phase containing an antibody to a first hapten, e.g., a fluorescein hapten, and (d) a bihapten comprising a first hapten and FK778 or an analogue of FK778, e.g., a bihapten comprising a fluorescein hapten and a FK778 hapten. In another aspect, the method and kit involve the use of (a) antibody to FK778, (b) a bihapten comprising FK778 or an analogue of FK778 and a first hapten, e.g., a bihapten comprising the fluorescein hapten and the hapten of FK778 or an analogue of FK778, and (c) a pretreatment reagent.

US Patent:

20070269841, Nov 22, 2007

Filed:

Jun 29, 2007

Appl. No.:

11/770907

Inventors:

Thomas Spring - Highland Park IL, US
Elaine Brate - Grayslake IL, US
Rajarathnam Reddy - Gurnee IL, US
Donald Johnson - Lindenhurst IL, US
You Pan - Libertyville IL, US

International Classification:

G01N 33/00

US Classification:

435007930

Abstract:

Methods and kits for measurement of concentration of FK778 in a biological sample by means of an immunoassay, preferably a competitive immunoassay. In one aspect, the method and kit involve the use of (a) an antibody to FK778 conjugated to a label, e.g., an acridinium label, (b) an antibody to FK778 not conjugated to a label, (c) a solid phase containing an antibody to a first hapten, e.g., a fluorescein hapten, and (d) a bihapten comprising a first hapten and FK778 or an analogue of FK778, e.g., a bihapten comprising a fluorescein hapten and a FK778 hapten. In another aspect, the method and kit involve the use of (a) antibody to FK778, (b) a bihapten comprising FK778 or an analogue of FK778 and a first hapten, e.g., a bihapten comprising the fluorescein hapten and the hapten of FK778 or an analogue of FK778, and (c) a pretreatment reagent.

US Patent:

56437218, Jul 1, 1997

Filed:

Feb 9, 1994

Appl. No.:

8/193972

Inventors:

Thomas G. Spring - Highland Park IL
John M. Brackett - Kenosha WI
Sheila A. Vogdes - Grayslake IL
Steven G. Schultz - Winthrop Harbor IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

G01N 33543
G01N 33545
G01N 33548
G01N 33551

US Classification:

435 6

Abstract:

The present invention provides an immobilization medium which can immobilize bioreagents to support materials and which dries to a water resistant layer or film. The immobilization medium comprises (i) a liquid or fluid binding reagent and (ii) complexes of a bioreagent immobilized to a solid phase which are evenly dispersed within the binding reagent. The suspension can further include supplemental ingredients evenly dispersed throughout the medium which can provide the medium with electrochemical properties, enhance the stability of the immobilized bioreagent and/or improve the medium's capability of drying to a substantially water resistant or insoluble layer. The immobilization medium provided by the instant invention is in the form of a homogeneous liquid suspension.

US Patent:

62614401, Jul 17, 2001

Filed:

Sep 12, 1997

Appl. No.:

8/928364

Inventors:

Timothy P. Henning - Vernon Hills IL
Thomas G. Spring - Highland Park IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

G01F 164

US Classification:

205792

Abstract:

Provided are microparticle forms of carbon, carbon catalysts and carbon-containing electrically conductive materials which are covalently linked to peroxidase. The carbon:peroxidase conjugates are suitable for use as substrates in conventional electrodes. Surprisingly, the conjugates display very little sensitivity to known interfering substances and thus are suitable for use as interference free electrodes.

US Patent:

57559538, May 26, 1998

Filed:

Dec 18, 1995

Appl. No.:

8/563728

Inventors:

Timothy P. Henning - Vernon Hills IL
Thomas G. Spring - Highland Park IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

G01N 2726

US Classification:

205778

Abstract:

Provided are microparticle forms of carbon, carbon catalysts and carbon-containing electrically conductive materials which are covalently linked to peroxidase. The carbon:peroxidase conjugates are suitable for use as substrates in conventional electrodes. Surprisingly, the conjugates display very little sensitivity to known interfering substances and thus are suitable for use as interference free electrodes.