Thomas M Stout

US Patent:

6515109, Feb 4, 2003

Filed:

Oct 12, 2001

Appl. No.:

09/976239

Inventors:

Michael Martin Ollmann - Redwood City CA
Kevin Patrick Keegan - San Diego CA
Thomas J. Stout - San Francisco CA
David Matthews - San Francisco CA
Alison Joly - San Mateo CA

Assignee:

Exelixis, Inc. - S. San Francisco CA

International Classification:

C07K 1400

US Classification:

530350

Abstract:

Human Ect2 polypeptide, fragments and derivatives, along with vectors and host cells for expression and production of Ect2 polypeptide are provided. Various methods of screening for agents that modulate interaction of Ect2 with an Ect2 binding agent, including high throughput methods, are also provided.

US Patent:

6579701, Jun 17, 2003

Filed:

Dec 14, 2000

Appl. No.:

09/738946

Inventors:

Kevin Patrick Keegan - San Leandro CA
Thomas J. Stout - San Francisco CA

Assignee:

Exelixis, Inc. - South San Francisco CA

International Classification:

C12P 2106

US Classification:

435 691, 4353201, 435325, 435455, 435243, 435410, 435348, 435352, 435358, 435468, 435471, 4352523, 43525411, 536 231, 536 235

Abstract:

Novel nucleic acids that are homologs of genes implicated in cancer are described that have been isolated from These novel nucleic acids can be used to genetically modify metazoan invertebrate organisms, such as insects and worms, or cultured cells, resulting in novel gene expression or mis-expression. The genetically modified organisms or cells can be used in screening assays to identify candidate compounds which are potential pesticidal agents or therapeutics that interact with gene products implicated in cancer. They can also be used in methods for studying gene activity and identifying other genes that modulate the function of, or interact with, genes implicated in cancer.

US Patent:

6630297, Oct 7, 2003

Filed:

Nov 7, 2002

Appl. No.:

10/289779

Inventors:

Michael Martin Ollmann - Redwood City CA
Kevin Patrick Keegan - San Diego CA
Thomas J. Stout - San Francisco CA
David Matthews - San Francisco CA
Alison Joly - San Mateo CA

Assignee:

Exelixis, Inc. - South San Francisco CA

International Classification:

C12Q 100

US Classification:

435 4, 435 71, 435 6, 435 721, 530350

Abstract:

Human Ect2 polypeptide, fragments and derivatives, along with vectors and host cells for expression and production of Ect2 polypeptide are provided. Various methods of screening for agents that modulate interaction of Ect2 with an Ect2 binding agent, including high throughput methods, are also provided.

US Patent:

20030049711, Mar 13, 2003

Filed:

Jun 26, 2002

Appl. No.:

10/184128

Inventors:

Allen Ebens - San Carlos CA, US
Thomas Stout - San Francisco CA, US
Stuart Johnston - Menlo Park CA, US
Dat Nguyen - Redwood City CA, US

International Classification:

C12Q001/37
C07H021/04
C12N009/64
A01N061/00
C12N005/06
C12P021/02

US Classification:

435/023000, 435/069100, 435/226000, 435/320100, 435/348000, 514/001000, 536/023200

Abstract:

The instant invention provides nucleic acid molecules encoding insect 26/29 cysteine protease, as well as 26/29 cysteine protease encoded thereby. The invention further provides methods of identifying agents that modulate a level of 26/29 cysteine protease mRNA, polypeptide, or enzyme activity. Such agents are candidate insecticidal compounds.

US Patent:

20030217376, Nov 20, 2003

Filed:

Nov 12, 2002

Appl. No.:

10/149165

Inventors:

Allen Ebens - San Carlos CA, US
Kevin Keegan - San Diego CA, US
Thomas Stout - San Francisco CA, US

International Classification:

A01K067/033
A01N061/00
C07H021/04
C12N009/88
C12P021/02
C12N005/06

US Classification:

800/008000, 435/232000, 435/069100, 435/320100, 435/348000, 514/001000, 536/023200

Abstract:

Nucleic acids isolated from that are lethal when knocked out in Drosophila, and proteins encoded thereby, are described. The nucleic acids and proteins can be used to genetically modify metazoan invertebrate organisms, such as insects and worms, or cultured cells, resulting in expression or mis-expression of the encoded proteins. The genetically modified organisms or cells can be used in screening assays to identify candidate compounds which are potential pesticidal agents or therapeutics that interact with subject proteins. They can also be used in methods for studying activity of subject proteins, and identifying other genes that modulate the function of, or interact with, the subject genes.

US Patent:

20210015563, Jan 21, 2021

Filed:

Oct 7, 2020

Appl. No.:

17/065290

Inventors:

- Casper WY, US
Michael Andrew Swartz - San Jose CA, US
Thomas Edward Stout - San Jose CA, US
Mike Zelina - Lakewood OH, US
Collin T. Stoner - San Leandro CA, US

International Classification:

A61B 34/20
A61B 90/00
A61B 34/00
A61B 34/30

Abstract:

Navigation assistance systems and methods for use with a surgical instrument to assist in navigation of a surgical instrument during an operation. The system may include sensors that may observe the patient to generate positioning data regarding the relative position of the surgical instrument and the patient. The system may retrieve imaging data regarding the patient and correlate the imaging data to the positioning data. In turn, the position of the surgical instrument relative to the imaging data may be provided and used to generate navigation date (e.g., position, orientation, trajectory, or the like) regarding the surgical instrument.

US Patent:

20190231443, Aug 1, 2019

Filed:

Oct 2, 2018

Appl. No.:

16/342154

Inventors:

- Casper WV, US
Michael Andrew Swartz - San Jose CA, US
Thomas Edward Stout - San Jose CA, US
Mike Zelina - Lakewood OH, US
Collin T. Stoner - San Leandro CA, US

International Classification:

A61B 34/20
A61B 34/30

Abstract:

Navigation assistance systems and methods for use with a surgical instrument to assist in navigation of a surgical instrument during an operation. The system may include sensors that may observe the patient to generate positioning data regarding the relative position of the surgical instrument and the patient. The system may retrieve imaging data regarding the patient and correlate the imaging data to the positioning data. In turn, the position of the surgical instrument relative to the imaging data may be provided and used to generate navigation date (e.g., position, orientation, trajectory, or the like) regarding the surgical instrument.