Saeid Seyedin - Sunnyvale CA Thomas Thomas - Concord CA Hanne Bentz - Palo Alto CA Larry Ellingsworth - San Jose CA Rosa Armstrong - Palo Alto CA
Assignee:
Collagen Corporation - Palo Alto CA
International Classification:
A61K 3712 A61K 3512 A01N 6302
US Classification:
530353
Abstract:
Two proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-. beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. Each is reduced to a single polypeptide indicating that the proteins are probably homodimers. One has an N-terminal sequence identical to that of human placenta-derived TGF-. beta. whereas the other has an N-terminal sequence that is different from that of TGF-. beta. derived from human placenta. The two proteins may be purified to homogeneity using RP-HPLC or acetic acid-urea gel electrophoresis.
Saeid Seyedin - Mountain View CA Thomas Thomas - Davis CA
Assignee:
Collagen Corporation - Palo Alto CA
International Classification:
A61K 3532
US Classification:
424 95
Abstract:
A partially purified proteinaceous bone-inducing factor of 10,000 to 30,000 daltons is described. It is derived from demineralized bovine bone by extraction with a chaotropic agent, gel filtration, cation exchange chromatography using carboxymethyl cellulose at pH 4. 8 and gradient elution with NaCl at 10 mM to about 150 mM.
Polypeptide Cartilage-Inducing Factors Found In Bone
Saeid Seyedin - Sunnyvale CA Thomas Thomas - Davis CA Hanne Bentz - Palo Alto CA Larry Ellingsworth - San Jose CA Rosa Armstrong - Palo Alto CA
Assignee:
Collagen Corporation - Palo Alto CA
International Classification:
C07G 700 A61K 900
US Classification:
514 2
Abstract:
Two proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-. beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. Each is reduced to a single polypeptide indicating that the proteins are probably homodimers. One has an N-terminal sequence identical to that of human placenta-derived TGF-. beta. whereas the other has an N-terminal sequence that is different from that of TGF-. beta. derived from human placenta. The two proteins may be purified to hmogeneity using RP-HPLC or acetic acid-urea gel electrophoresis.
Polypeptide Cartilage-Inducing Factors Found In Bone
Saeid Seyedin - Sunnyvale CA Thomas Thomas - Davis CA Hanne Bentz - Palo Alto CA Larry Ellingsworth - San Jose CA Rosa Armstrong - Palo Alto CA
Assignee:
Collagen Corporation - Palo Alto CA
International Classification:
A61K 3702 C07K 328
US Classification:
514 2
Abstract:
Two proteins that are found is bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-. beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. Each is reduced to a single polypeptide indicating that the proteins are probably homodimers. One has an N-terminal sequence identical to that of human placenta-derived TGF-. beta. whereas the other has an N-terminal sequence that is different from that of TGF-. beta. derived from human placenta. The two proteins may be purified to homogeneity using RP-HPLC or acetic acid-urea gel electrophoresis.
Partially Purified Osteogenic Factor And Process For Preparing Same From Demineralized Bone
Saeid Seyedin - Mt. View CA Thomas Thomas - Palo Alto CA
Assignee:
Collagen Corporation - Palo Alto CA
International Classification:
C07G 700
US Classification:
260112R
Abstract:
A process for partially purifying an osteogenic factor from demineralized bone particles in which nonfibrous proteins are extracted from the demineralized bone with a dissociative extractant for nonfibrous proteins, such as urea or guanidine hydrochloride, the extracted nonfibrous proteins are fractionated by anion exchange chromatography using DEAE cellulose at pH 7, the fraction not adsorbed by the DEAE cellulose is further fractionated by cation exchange chromatography using CM cellulose at pH 4. 8, the fraction adsorbed by the CM cellulose is eluted therefrom and the partially purified osteogenic factor is recovered from the eluate as a. ltoreq. 30,000 dalton protein isolate.
Polypeptide Cartilage-Inducing Factors Found In Bone Used In Tissue Proliferation
Saeid Seyedin - Sunnyvale CA Thomas Thomas - Concord CA Hanne Bentz - Palo Alto CA Larry Ellingsworth - San Jose CA Rosa Armstrong - Palo Alto CA
Assignee:
Collagen Corporation - Palo Alto CA
International Classification:
A61F 200 A61K 3712 A61K 3512
US Classification:
514 21
Abstract:
Two proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-. beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. Each is reduced to a single polypeptide indicating that the proteins are probably homodimers. One has an N-terminal sequence identical to that of human placenta-derived TGF-. beta. whereas the other has an N-terminal sequence that is different from that of TGF-. beta. derived from human placenta. The two proteins may be purified to homogeneity using RP-HPLC or acetic acid-urea gel electrophoresis.
A method of repairing windshields that have been chipped or cracked comprising the steps of removing damaged glass from a break in the surface of the glass, fixing a pressure applier over the break, impact vibrating the windshield and heating the reverse side of the windshield to increase the size of the opening being filled and to drive air from the opening, injecting a resin into the damaged area while vibrating and heating and, if necessary, removing any additional air by developing a suction over the damaged area. The apparatus of the invention includes a frame that is suction held in place, and that mounts the injection plunger and a vibrator to vibrate the glass as a resin is injected into openings in the glass.
Vehicle Frame Anchoring And Alignment Platform System
The present invention is a vehicle frame anchoring and alignment platform system. Because of the adjustability and modularity of the vehicle frame anchoring and alignment platform system, the system is adapted to minimize pull setups and takedowns, tool assembly and disassembly, and vehicle disassembly and assembly when used in aligning a vehicle frame.
2010 to 2000 Special Advisor for The Department of State-PRTCivil Affairs Team Fayetteville, NC 2008 to 2010 Bilingual Bicultural AdvisorPacific Guarantee Mortgage Foster City, CA 1994 to 2007 Mortgage BrokerEIC Group Redwood City, CA 1988 to 1994 Investment ConsultantWentworth Laboratories Inc Sunnyvale, CA 1985 to 1988 Quality Control Manager
Education:
University of Sulaimanyah 1976 B.Sc. in Chemistry Science
Medical School George Washington University School Of Medicine Graduated: 1973 Medical School Jackson Meml Hospital University Miami Graduated: 1974 Medical School Jackson Meml Hospital University Miami Graduated: 1977
Grace Health 181 Emmett St W, Battle Creek, MI 49037 2699658866 (phone), 2699662627 (fax)
Oaklawn Marshall Intnl/Fam MednOaklawn Medical Group Marshall Internal & Family Medicine 720 Old Us Hwy 27 N, Marshall, MI 49068 2697816600 (phone), 2697819228 (fax)
Education:
Medical School Wake Forest University School of Medicine Graduated: 1995
Procedures:
Cesarean Section (C-Section) D & C Dilation and Curettage Delivery After Previous Caesarean Section Skin Tags Removal Tubal Surgery Vaccine Administration Vaginal Delivery Vaginal Repair
Conditions:
Breast Disorders Menopausal and Postmenopausal Disorders Uterine Leiomyoma Abnormal Vaginal Bleeding Candidiasis of Vulva and Vagina
Languages:
English Spanish
Description:
Dr. Thomas graduated from the Wake Forest University School of Medicine in 1995. He works in Marshall, MI and 1 other location and specializes in Obstetrics & Gynecology. Dr. Thomas is affiliated with Bronson Battle Creek Hospital and Ella Mae Brown Oaklawn Hospital.
Holston Medical GroupHolston Medical Group General Surgery At Medical Plaza 105 W Stone Dr STE 4A, Kingsport, TN 37660 4233926265 (phone), 4233926272 (fax)
Education:
Medical School Washington University School of Medicine Graduated: 1992
Abdominal Hernia Appendicitis Cholelethiasis or Cholecystitis Hemorrhoids Inguinal Hernia
Languages:
English
Description:
Dr. Thomas graduated from the Washington University School of Medicine in 1992. He works in Kingsport, TN and specializes in General Surgery. Dr. Thomas is affiliated with Holston Valley Medical Center and Indian Path Medical Center.
Dr. Thomas graduated from the University of Missouri, Columbia School of Medicine in 1962. He works in Liberty, MO and specializes in Family Medicine and Allergy. Dr. Thomas is affiliated with Liberty Hospital and North Kansas City Hospital.
Dr. Thomas graduated from the Des Moines University College of Osteopathic Medicine in 1993. He works in Springfield, MO and specializes in Internal Medicine. Dr. Thomas is affiliated with Mercy Hospital Springfield.
Anesthesia Medical GroupAnesthesia Medical Group PC 2000 Church St, Nashville, TN 37236 6153274304 (phone), 6153277940 (fax)
Anesthesia Medical Group 5655 Frist Blvd, Hermitage, TN 37076 6153277870 (phone), 6153275435 (fax)
Anesthesia Medical Group 4220 Harding Pike, Nashville, TN 37205 6153277880 (phone), 6153275435 (fax)
Saint Thomas Surgicare 4230 Harding Pike STE 300, Nashville, TN 37205 6157831260 (phone), 6157831261 (fax)
Education:
Medical School University of Utah School of Medicine Graduated: 1984
Languages:
English French Spanish
Description:
Dr. Thomas III graduated from the University of Utah School of Medicine in 1984. He works in Nashville, TN and 3 other locations and specializes in Anesthesiology. Dr. Thomas III is affiliated with Saint Thomas Midtown Hospital, Saint Thomas West Hospital, Tristar Centennial Medical Center, Tristar Medical Center, Vanderbilt Stallworth Rehabilitation Hospital and Williamson Medical Center.
West Palm Beach VA Medical Center 7305 N Military Trl, Palm Beach Gardens, FL 33410 5614228262 (phone), 5614228708 (fax)
Education:
Medical School T.d. Med Coll, Univ of Kerala, Aleppey, Kerala, India Graduated: 1977
Languages:
English Spanish
Description:
Dr. Thomas graduated from the T.d. Med Coll, Univ of Kerala, Aleppey, Kerala, India in 1977. He works in Riviera Beach, FL and specializes in Internal Medicine. Dr. Thomas is affiliated with VA Medical Center Of West Palm Beach.