Thomas N Tulenko

US Patent:

20140056806, Feb 27, 2014

Filed:

Oct 15, 2012

Appl. No.:

13/652408

Inventors:

Rowan University - , US
Jennifer KADLOWEC - Haddon Township NJ, US
Pamela KUBINSKI - Jackson NJ, US
Thomas N. TULENKO - Ambler PA, US
Cristina IFTODE - Princeton NJ, US
Bryan JOHNSON - Philadelphia PA, US
Craig WILTSEY - Mantua NJ, US

Assignee:

Rowan University - Glassboro NJ

International Classification:

A61L 27/52
A61L 27/26

US Classification:

424 111, 424400, 424 937

Abstract:

The disclosure relates to a composition that is liquid at a temperature below the body temperature of a mammal and that solidifies at or above the body temperature of the mammal. The composition includes a thermally-desolubilizable polymer interspersed with a polymeric component of extracellular matrix and an encapsulated form of an amine compound (preferably an aminated component of extracellular matrix) that is de-encapsulated in the body of the mammal. The polymeric component is able to form covalent bonds with amine moieties in the aminated component, in one or more tissues in the body of the mammal, or both. Upon injection of a liquid suspension of these components into the body of the mammal, the thermally-desolubilizable polymer condenses, entrapping the polymeric component. The polymeric component binds covalently with a tissue in the body, and the aminated component end-caps the remaining reactive moieties of the polymeric component, forming a matrix at the site of injection. The disclosure also relates to uses of such compositions for forming a matrix on or within the body of a mammal. The compositions have a variety of uses, such as as bioadhesives, as sealants for ruptured tissues, as drug or imaging agent depots, or as mechanical cushions.

US Patent:

42297338, Oct 21, 1980

Filed:

Aug 10, 1978

Appl. No.:

5/932553

Inventors:

Thomas N. Tulenko - Philadelphia PA
Carmen A. Di Camillo - Philadelphia PA

International Classification:

G08B 2300
G08B 1712
G01J 142

US Classification:

340500

Abstract:

An exposure detecting device comprising a radiation detector means providing an output signal responsive to the intensity of received ultraviolet radiation, a storage means receiving the output signal of said detector means and providing an output signal which increases as a function of the signal received and its duration, and decreases in the absence of a received signal as a predetermined function of time. A sensitivity control means provides a reference signal, and comparing means receives the output signal of said storage means and the reference signal of said sensitivity control means and delivers an output signal when the storage means output signal exceeds a predetermined value with respect to the reference signal. Alarm means is activated upon receiving an output signal from said comparing means providing an alarm.

US Patent:

20170000923, Jan 5, 2017

Filed:

Sep 19, 2016

Appl. No.:

15/269404

Inventors:

- Glassboro NJ, US
Jennifer Kadlowec - Haddon Township NJ, US
Pamela Kubinski - Jackson NJ, US
Thomas N. Tulenko - Ambler PA, US
Cristina Iftode - Princeton NJ, US
Bryan Johnson - Philadelphia PA, US
Craig Wiltsey - Mantua NJ, US

Assignee:

Rowan University - Glassboro NJ

International Classification:

A61L 24/04
A61F 2/00
A61L 24/00

Abstract:

The disclosure relates to a composition that is liquid at a temperature below the body temperature of a mammal and that solidifies at or above the body temperature of the mammal. The composition includes a thermally-desolubilizable polymer interspersed with a polymeric component of extracellular matrix and an encapsulated form of an amine compound (preferably an aminated component of extracellular matrix) that is de-encapsulated in the body of the mammal. The polymeric component is able to form covalent bonds with amine moieties in the aminated component, in one or more tissues in the body of the mammal, or both. Upon injection off liquid suspension of these components into the body of the mammal, the thermally-desolubilizable polymer condenses, entrapping the polymeric component. The polymeric component binds covalently with a tissue in the body, and the aminated component end-caps the remaining reactive moieties of the polymeric component, forming a matrix at the site of injection. The disclosure also relates to uses of such compositions for forming a matrix on or within the body of a mammal. The compositions have a variety of uses, such as bioadhesives, as sealants for ruptured tissues, as drug or imaging agent depots, or as mechanical cushions.

US Patent:

20160158406, Jun 9, 2016

Filed:

Feb 11, 2016

Appl. No.:

15/041170

Inventors:

- Glassboro NJ, US
Jennifer Kadlowec - Haddon Township NJ, US
Pamela Kubinski - Jackson NJ, US
Thomas N. Tulenko - Ambler PA, US
Cristina Iftode - Princeton NJ, US
Bryan Johnson - Philadelphia PA, US
Craig Wiltsey - Mantua NJ, US

Assignee:

Rowan University - Glassboro NJ

International Classification:

A61L 24/04
A61F 2/00
A61L 24/00

Abstract:

The disclosure relates to a composition that is liquid at a temperature below the body temperature of a mammal and that solidifies at or above the body temperature of the mammal. The composition includes a thermally-desolubilizable polymer interspersed with a polymeric component of extracellular matrix and an encapsulated form of an amine compound (preferably an aminated component of extracellular matrix) that is de-encapsulated in the body of the mammal. The polymeric component is able to form covalent bonds with amine moieties in the aminated component, in one or more tissues in the body of the mammal, or both. Upon injection of a liquid suspension of these components into the body of the mammal, the thermally-desolubilizable polymer condenses, entrapping the polymeric component. The polymeric component binds covalently with a tissue in the body, and the aminated component end-caps the remaining reactive moieties of the polymeric component, forming a matrix at the site of injection. The disclosure also relates to uses of such compositions for forming a matrix on or within the body of a mammal. The compositions have a variety of uses, such as bioadhesives, as sealants for ruptured tissues, as drug or imaging agent depots, or as mechanical cushions.