Ramesh N. Patel - Bridgewater NJ Amit Banerjee - St. Louis MO Venkata B. Nanduri - East Brunswick NJ Steven L. Goldberg - Basking Ridge NJ Robert M. Johnston - Whitehouse Station NJ Thomas P. Tully - Middlesex NJ Laszlo J. Szarka - East Brunswick NJ Shankar Swaminathan - North Brunswick NJ John J. Venit - North Brunswick NJ Jerome L. Moniot - Chester NJ William J. Winter - New Brunswick NJ Neal G. Anderson - Stockton NJ David A. Lust - Roosevelt NJ Gerard Crispino - Princeton NJ Sushil K. Srivastava - Dayton NJ
Assignee:
Bristol-Myers Squibb Co. - Princeton NJ
International Classification:
C07C 3200
US Classification:
562432, 562433, 562426, 562485, 562400
Abstract:
The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.
Enzymatic Preparation Of (S) Amino Acid From (R,S) Amino Acid Or From Keto Acid
Ramesh Patel - Bridgewater NJ, US Yijun Chen - Belle Mead NJ, US Steven Goldberg - Basking Ridge NJ, US Iqbal Gill - Denville NJ, US Animesh Goswami - Plainsboro NJ, US Thomas Tully - Middlesex NJ, US William Parker - Pennington NJ, US Ronald Hanson - Morris Plains NJ, US
Disclosed and claimed herein are novel biocatalysts for converting racemic mixtures of amino acids to an enantiomerically pure (S) form of the amino acid, methods for their use, and the enantiomerically enriched products of such biocatalytic processes.
Betulinic Acid Derivatives With Hiv Maturation Inhibitory Activity
- Brentford, Middlesex, GB Animesh GOSWAMI - New Brunswick NJ, US Zhiwei GUO - Sammamish WA, US Thomas P. TULLY - New Brunswick NJ, US Jacob SWIDORSKI - Wallingford CT, US Zheng LIU - Wallingford CT, US Nicholas A. MEANWELL - Wallingford CT, US
International Classification:
C07J 63/00 C07J 71/00
Abstract:
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivaties that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III:These compounds are useful for the treatment of HIV and AIDS.
St. John The Baptist School New Brunswick NJ 1962-1968, Saint Frances Cabrini School Piscataway NJ 1968-1972, St. Pius X High School Piscataway NJ 1972-1974
Community:
Tom Laudino, Elaine Quinet, Beth Mason, Bill Borwegen, Teresa Malok, Nancy Szabo, Diane Denicola