Thomas Michael Wood

US Patent:

7521534, Apr 21, 2009

Filed:

Mar 3, 2004

Appl. No.:

10/793339

Inventors:

Allan R. Brasier - Galveston TX, US
Tao Hai - Galveston TX, US
Thomas G. Wood - Houston TX, US
Yuanfen Wei - Galveston TX, US

Assignee:

The University Board of Regents of Texas System - Austin TX

International Classification:

C07K 1/00

US Classification:

530350

Abstract:

Disclosed are isolated IKKγΔ; isolated nucleic acid molecules encoding IKKγΔ; expression vectors and cells which contain such nucleic acid molecules; oligonucleotides which are complementary to at least a portion of nucleic acid molecules encoding IKKγΔ but which are not complementary to any portion of nucleic acid molecules encoding wild type IKKγ; antibodies which are specific for IKKγΔ; DNA and RNA oligomers, optionally in labeled or enzymatically active form, which are capable of selectively hybridizing to nucleic acid molecules encoding IKKγΔ; and DNA and RNA oligomers, optionally in labeled or enzymatically active form, which are capable of selectively hybridizing to nucleic acid molecules encoding IKKγΔ but which do not hybridize with nucleic acid molecules encoding wild type IKKγ. Methods for using these materials to inhibit formation of IKKγΔ-containing IKK, to inhibit NF-κB activation, and to treat or prevent inflammation are also disclosed.

US Patent:

20030166548, Sep 4, 2003

Filed:

Jun 19, 2002

Appl. No.:

10/175270

Inventors:

Johnny Peterson - Dickinson TX, US
Shamsher Saini - Galveston TX, US
Thomas Wood - Houston TX, US
Ashok Chopra - Galveston TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

A61K038/17
G01N033/53

US Classification:

514/012000, 435/007100

Abstract:

Synthetic milittin and related peptides derived from the sequence of human phospholipase A-activating protein (PLAP), free from the contaminating phospholipase A(PLA) and/or present when the peptides are purified from natural sources, show inhibitory activity against PLA. Inhibition of this enzyme, responsible for the hydrolysis of arachiodonate, an important precursor of eicosanoids, should lead to a decrease in the inflammatory response. In addition to their use as anti-inflammatory therapeutics, compositions containing the synthetic peptides may also be useful therapeutic tools for diagnosing inflammatory diseases (e.g., Crohn's disease, ulcerative colitis, rheumatoid arthritis).

US Patent:

20120263651, Oct 18, 2012

Filed:

Apr 12, 2012

Appl. No.:

13/445558

Inventors:

Steven G. Widen - Galveston TX, US
Thomas G. Wood - Houston TX, US
Allan R. Brasier - Galveston TX, US
Yingxin Zhao - Houston TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

A61K 31/7088
G01N 27/62
C12N 5/071
G01N 21/64
G01N 27/72
A61K 49/00
A61P 29/00
A61P 1/00
A61P 11/06
A61P 35/00
A61K 9/127
G01N 33/566
C07H 21/04
B82Y 15/00

US Classification:

424 91, 436501, 435375, 536 231, 514 44 A, 424450, 977774, 977773

Abstract:

DNA aptamers are high affinity ligands selected by genetic enrichment techniques to bind to specific protein targets. Because these represent chemically stable and reproducible molecules, they have application as affinity reagents and/or therapeutic drugs to affect the target protein's actions. NF-kB is an important mediator of the innate immune response and mediator of tissue inflammation. Although RNA and double stranded DNA aptamers have been identified to bind to the NF-kB family of proteins, the present invention represents the first identification of single stranded DNA aptamers that recognize NFkB RelA. The aptamers disclosed herein bind to several distinct regions of RelA and may be useful to antagonize the DNA binding of RelA as an inhibitor of cellular inflammation, visualize the location or amount of RelA in tissues from pathological conditions, or to quantitatively measure the activated state of RelA by affinity binding.

US Patent:

57862133, Jul 28, 1998

Filed:

Apr 18, 1996

Appl. No.:

8/634546

Inventors:

Pomila Singh - Galveston TX
Thomas G. Wood - Houston TX

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C12N 500

US Classification:

4353201

Abstract:

The present invention discloses is for the treatment of colon cancer. The expression of gastrin by colon cancers is inhibited by the use of antisense gastrin expression. Methods are disclosed for the preparation of expression constructs and the use of such constructs to inhibit colon cancer growth.

US Patent:

61659908, Dec 26, 2000

Filed:

May 15, 1998

Appl. No.:

9/079372

Inventors:

Pomila Singh - Galveston TX
Thomas G. Wood - Houston TX

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

A61K 4800

US Classification:

514 44

Abstract:

The present invention discloses methods for the treatment of colon cancer. The expression of gastrin by colon cancers is inhibited by the use of antisense gastrin expression. Methods are disclosed for the preparation of expression constructs and the use of such constructs to inhibit colon cancer growth.

US Patent:

20150339948, Nov 26, 2015

Filed:

May 22, 2015

Appl. No.:

14/719482

Inventors:

Thomas James Wood - Houston TX, US
Alan Roachell - Houston TX, US
David Truax - Houston TX, US
Tom Wood - Houston TX, US
Mike Rowan - Houston TX, US

International Classification:

G09B 19/00
G09B 5/06
G06N 5/02

Abstract:

A knowledge system is provided that is operable for producing how-to segments of information for use with a maintenance system, an equipment and asset tracking system, and a job function competency system to utilize a plurality of types of display devices for maintaining a plurality of types of industrial assets located at a plurality of locations. In one embodiment, a low energy communicator is mounted to said each of said plurality of industrial equipment assets and operable for providing more precise location information of a selected industrial equipment asset.

US Patent:

20150259687, Sep 17, 2015

Filed:

Mar 30, 2015

Appl. No.:

14/673572

Inventors:

- Austin TX, US
Thomas G. Wood - Houston TX, US
Allan R. Brasier - Galveston TX, US
Yingxin Zhao - Houston TX, US

International Classification:

C12N 15/115
G01N 33/53

Abstract:

DNA aptamers are high affinity ligands selected by genetic enrichment techniques to bind to specific protein targets. Because these represent chemically stable and reproducible molecules, they have application as affinity reagents and/or therapeutic drugs to affect the target protein's actions. NF-kB is an important mediator of the innate immune response and mediator of tissue inflammation. Although RNA and double stranded DNA aptamers have been identified to bind to the NF-kB family of proteins, the present invention represents the first identification of single stranded DNA aptamers that recognize NFkB RelA. The aptamers disclosed herein bind to several distinct regions of RelA and may be useful to antagonize the DNA binding of RelA as an inhibitor of cellular inflammation, visualize the location or amount of RelA in tissues from pathological conditions, or to quantitatively measure the activated state of RelA by affinity binding.

Address:

16310 Harvest Summer Ct, Houston, TX 77059

VIN:

1NXBR32E07Z882908

Make:

TOYOTA

Model:

COROLLA

Year:

2007