Thomas Allen Wood

US Patent:

7521534, Apr 21, 2009

Filed:

Mar 3, 2004

Appl. No.:

10/793339

Inventors:

Allan R. Brasier - Galveston TX, US
Tao Hai - Galveston TX, US
Thomas G. Wood - Houston TX, US
Yuanfen Wei - Galveston TX, US

Assignee:

The University Board of Regents of Texas System - Austin TX

International Classification:

C07K 1/00

US Classification:

530350

Abstract:

Disclosed are isolated IKKγΔ; isolated nucleic acid molecules encoding IKKγΔ; expression vectors and cells which contain such nucleic acid molecules; oligonucleotides which are complementary to at least a portion of nucleic acid molecules encoding IKKγΔ but which are not complementary to any portion of nucleic acid molecules encoding wild type IKKγ; antibodies which are specific for IKKγΔ; DNA and RNA oligomers, optionally in labeled or enzymatically active form, which are capable of selectively hybridizing to nucleic acid molecules encoding IKKγΔ; and DNA and RNA oligomers, optionally in labeled or enzymatically active form, which are capable of selectively hybridizing to nucleic acid molecules encoding IKKγΔ but which do not hybridize with nucleic acid molecules encoding wild type IKKγ. Methods for using these materials to inhibit formation of IKKγΔ-containing IKK, to inhibit NF-κB activation, and to treat or prevent inflammation are also disclosed.

US Patent:

8153541, Apr 10, 2012

Filed:

Jul 17, 2008

Appl. No.:

12/174982

Inventors:

Thomas W. McCullough - Lake Jackson TX, US
James E. Schuetz - Sanford MI, US
Thomas D. Wood - Houghton MI, US

Assignee:

Century, Inc. - Traverse City MI

International Classification:

C04B 35/00
B29C 47/60

US Classification:

501 952, 501 951, 26421123

Abstract:

A ceramic article comprises ceramic fibers having an aspect ratio of greater than 3:1 and ceramic particles. The ceramic fibers are substantially randomly oriented in three dimensions in the ceramic article. A method of forming the ceramic article includes the step of providing a composition including ceramic fibers having an aspect ratio of greater than 3:1 and ceramic particles. The composition is extruded through a multi-screw extruder having at least three intermeshing screws to form an extrudate. The extrudate is heated to form the ceramic article.

US Patent:

8455379, Jun 4, 2013

Filed:

Apr 10, 2012

Appl. No.:

13/443292

Inventors:

Thomas W. McCullough - Lake Jackson TX, US
James E. Schuetz - Sanford MI, US
Thomas D. Wood - Houghton MI, US

Assignee:

Century, Inc. - Traverse City MI

International Classification:

C04B 35/00

US Classification:

501 952

Abstract:

A ceramic article comprises ceramic fibers having an aspect ratio of greater than or equal to 10:1, ceramic particles, and an inorganic binder comprising silica. Greater than 90 out of 100 ceramic fibers are randomly oriented in three dimensions in the ceramic article, and greater than 85 out of 100 ceramic fibers are spaced at least one ceramic fiber diameter away from an adjacent ceramic fiber. The ceramic article has a consistent density of from 0. 9 to 1. 1 g/cmin x-, y-, and z-dimensions and has a uniform strength in three dimensions as measured in accordance with ASTM C1424.

US Patent:

20030166548, Sep 4, 2003

Filed:

Jun 19, 2002

Appl. No.:

10/175270

Inventors:

Johnny Peterson - Dickinson TX, US
Shamsher Saini - Galveston TX, US
Thomas Wood - Houston TX, US
Ashok Chopra - Galveston TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

A61K038/17
G01N033/53

US Classification:

514/012000, 435/007100

Abstract:

Synthetic milittin and related peptides derived from the sequence of human phospholipase A-activating protein (PLAP), free from the contaminating phospholipase A(PLA) and/or present when the peptides are purified from natural sources, show inhibitory activity against PLA. Inhibition of this enzyme, responsible for the hydrolysis of arachiodonate, an important precursor of eicosanoids, should lead to a decrease in the inflammatory response. In addition to their use as anti-inflammatory therapeutics, compositions containing the synthetic peptides may also be useful therapeutic tools for diagnosing inflammatory diseases (e.g., Crohn's disease, ulcerative colitis, rheumatoid arthritis).

US Patent:

20090309262, Dec 17, 2009

Filed:

Jul 17, 2008

Appl. No.:

12/175007

Inventors:

Thomas W. McCullough - Lake Jackson TX, US
James E. Schuetz - Sanford MI, US
Neil Anderson - Calumet MI, US
Justin LaCosse - Calumet MI, US
Thomas D. Wood - Houghton MI, US

Assignee:

CENTURY, INC. - Traverse City MI

International Classification:

B28B 21/42

US Classification:

264310, 425111

Abstract:

The present invention relates to a method of forming a preform from a material having a first edge and a second edge utilizing a mandrel. The method comprises the step of extruding the material through an extruder to form an extrudate. The first edge of the extrudate has a configuration complementary to a configuration of the second edge of the extrudate. The method also includes wrapping the material around the mandrel by abutting the first edge and the second edge to form a spiral joint.The invention uses a manufacturing apparatus comprising a multi-screw extruder having at least three intermeshing screws for forming the extrudate. The mandrel receives the extrudate and a pressure-applying device adjacent to the mandrel engages the extrudate and applies pressure to the spiral joint to create a smooth exterior surface of the extrudate and to define the preform.

US Patent:

20120263651, Oct 18, 2012

Filed:

Apr 12, 2012

Appl. No.:

13/445558

Inventors:

Steven G. Widen - Galveston TX, US
Thomas G. Wood - Houston TX, US
Allan R. Brasier - Galveston TX, US
Yingxin Zhao - Houston TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

A61K 31/7088
G01N 27/62
C12N 5/071
G01N 21/64
G01N 27/72
A61K 49/00
A61P 29/00
A61P 1/00
A61P 11/06
A61P 35/00
A61K 9/127
G01N 33/566
C07H 21/04
B82Y 15/00

US Classification:

424 91, 436501, 435375, 536 231, 514 44 A, 424450, 977774, 977773

Abstract:

DNA aptamers are high affinity ligands selected by genetic enrichment techniques to bind to specific protein targets. Because these represent chemically stable and reproducible molecules, they have application as affinity reagents and/or therapeutic drugs to affect the target protein's actions. NF-kB is an important mediator of the innate immune response and mediator of tissue inflammation. Although RNA and double stranded DNA aptamers have been identified to bind to the NF-kB family of proteins, the present invention represents the first identification of single stranded DNA aptamers that recognize NFkB RelA. The aptamers disclosed herein bind to several distinct regions of RelA and may be useful to antagonize the DNA binding of RelA as an inhibitor of cellular inflammation, visualize the location or amount of RelA in tissues from pathological conditions, or to quantitatively measure the activated state of RelA by affinity binding.

US Patent:

57862133, Jul 28, 1998

Filed:

Apr 18, 1996

Appl. No.:

8/634546

Inventors:

Pomila Singh - Galveston TX
Thomas G. Wood - Houston TX

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C12N 500

US Classification:

4353201

Abstract:

The present invention discloses is for the treatment of colon cancer. The expression of gastrin by colon cancers is inhibited by the use of antisense gastrin expression. Methods are disclosed for the preparation of expression constructs and the use of such constructs to inhibit colon cancer growth.

US Patent:

61659908, Dec 26, 2000

Filed:

May 15, 1998

Appl. No.:

9/079372

Inventors:

Pomila Singh - Galveston TX
Thomas G. Wood - Houston TX

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

A61K 4800

US Classification:

514 44

Abstract:

The present invention discloses methods for the treatment of colon cancer. The expression of gastrin by colon cancers is inhibited by the use of antisense gastrin expression. Methods are disclosed for the preparation of expression constructs and the use of such constructs to inhibit colon cancer growth.

Address:

16310 Harvest Summer Ct, Houston, TX 77059

VIN:

1NXBR32E07Z882908

Make:

TOYOTA

Model:

COROLLA

Year:

2007