Thomas B Wood

US Patent:

7521534, Apr 21, 2009

Filed:

Mar 3, 2004

Appl. No.:

10/793339

Inventors:

Allan R. Brasier - Galveston TX, US
Tao Hai - Galveston TX, US
Thomas G. Wood - Houston TX, US
Yuanfen Wei - Galveston TX, US

Assignee:

The University Board of Regents of Texas System - Austin TX

International Classification:

C07K 1/00

US Classification:

530350

Abstract:

Disclosed are isolated IKKγΔ; isolated nucleic acid molecules encoding IKKγΔ; expression vectors and cells which contain such nucleic acid molecules; oligonucleotides which are complementary to at least a portion of nucleic acid molecules encoding IKKγΔ but which are not complementary to any portion of nucleic acid molecules encoding wild type IKKγ; antibodies which are specific for IKKγΔ; DNA and RNA oligomers, optionally in labeled or enzymatically active form, which are capable of selectively hybridizing to nucleic acid molecules encoding IKKγΔ; and DNA and RNA oligomers, optionally in labeled or enzymatically active form, which are capable of selectively hybridizing to nucleic acid molecules encoding IKKγΔ but which do not hybridize with nucleic acid molecules encoding wild type IKKγ. Methods for using these materials to inhibit formation of IKKγΔ-containing IKK, to inhibit NF-κB activation, and to treat or prevent inflammation are also disclosed.

US Patent:

8635671, Jan 21, 2014

Filed:

May 31, 2011

Appl. No.:

13/118841

Inventors:

Thomas Alexander Wood - Raleigh NC, US
Daniel P. Radez - Apex NC, US

Assignee:

Red Hat, Inc. - Raleigh NC

International Classification:

H04L 29/06

US Classification:

726 4, 713166, 713168

Abstract:

In accordance with some aspects of the present disclosure, a method is disclosed that can include receiving, by a security delegate module, a set of user authentication credentials by an application running a first instance in a network for a user; determining, by the security delegate module, a type of the application; and selecting, by the security delegate module, a security service based on the set of user authentication credentials and the type of application.

US Patent:

20030166548, Sep 4, 2003

Filed:

Jun 19, 2002

Appl. No.:

10/175270

Inventors:

Johnny Peterson - Dickinson TX, US
Shamsher Saini - Galveston TX, US
Thomas Wood - Houston TX, US
Ashok Chopra - Galveston TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

A61K038/17
G01N033/53

US Classification:

514/012000, 435/007100

Abstract:

Synthetic milittin and related peptides derived from the sequence of human phospholipase A-activating protein (PLAP), free from the contaminating phospholipase A(PLA) and/or present when the peptides are purified from natural sources, show inhibitory activity against PLA. Inhibition of this enzyme, responsible for the hydrolysis of arachiodonate, an important precursor of eicosanoids, should lead to a decrease in the inflammatory response. In addition to their use as anti-inflammatory therapeutics, compositions containing the synthetic peptides may also be useful therapeutic tools for diagnosing inflammatory diseases (e.g., Crohn's disease, ulcerative colitis, rheumatoid arthritis).

US Patent:

20120227095, Sep 6, 2012

Filed:

Mar 4, 2011

Appl. No.:

13/040774

Inventors:

Thomas Alexander Wood - Raleigh NC, US
Daniel Radez - Apex NC, US

International Classification:

G06F 7/04

US Classification:

726 5

Abstract:

Embodiments of the present teachings relate to systems and methods for generating modular security delegates for applications. According to embodiments, in a multiple network environment, multiple machines (or clients) can be configured. Each machine can include a plurality of application instances and an authentication delegate. In addition, each network environment can include a communication interface to security services. The applications can include logic that indicates what security delegate to use for a given set of user authentication credentials. The logic can be configured to determine the appropriate authentication delegate using various methods. The authentication delegates can receive a set of user authentication credentials from application instances and determine whether the set of user authentication credentials are valid. Each authentication delegate corresponds to one and only one type of authentication mechanism.

US Patent:

20120240212, Sep 20, 2012

Filed:

Mar 15, 2011

Appl. No.:

13/048142

Inventors:

Thomas Alexander Wood - Raleigh NC, US
Daniel P. Radez - Apex NC, US

International Classification:

H04L 9/32
G06F 21/00

US Classification:

726 10, 726 5

Abstract:

Embodiments of the present teachings relate to systems and methods for generating modular security delegates for application instances, including, for example, applications usable on physical machines, virtualized environments, in the cloud, etc. According to embodiments, in a multiple network environment, multiple machines (or clients) can be configured, each having a defined security level. Each machine can include a plurality of application instances and corresponding security delegates for various defined security levels. For example, the defined security levels can be based on various authentication mechanisms, including, Kerberos, NT Lan Manager (NTLM) authentication protocol, secure sockets layer/transport security layer (SSL/TSL), token authentication, virtual private network (VPN), remote access security (RAS), digest authentication, etc.

US Patent:

20120263651, Oct 18, 2012

Filed:

Apr 12, 2012

Appl. No.:

13/445558

Inventors:

Steven G. Widen - Galveston TX, US
Thomas G. Wood - Houston TX, US
Allan R. Brasier - Galveston TX, US
Yingxin Zhao - Houston TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

A61K 31/7088
G01N 27/62
C12N 5/071
G01N 21/64
G01N 27/72
A61K 49/00
A61P 29/00
A61P 1/00
A61P 11/06
A61P 35/00
A61K 9/127
G01N 33/566
C07H 21/04
B82Y 15/00

US Classification:

424 91, 436501, 435375, 536 231, 514 44 A, 424450, 977774, 977773

Abstract:

DNA aptamers are high affinity ligands selected by genetic enrichment techniques to bind to specific protein targets. Because these represent chemically stable and reproducible molecules, they have application as affinity reagents and/or therapeutic drugs to affect the target protein's actions. NF-kB is an important mediator of the innate immune response and mediator of tissue inflammation. Although RNA and double stranded DNA aptamers have been identified to bind to the NF-kB family of proteins, the present invention represents the first identification of single stranded DNA aptamers that recognize NFkB RelA. The aptamers disclosed herein bind to several distinct regions of RelA and may be useful to antagonize the DNA binding of RelA as an inhibitor of cellular inflammation, visualize the location or amount of RelA in tissues from pathological conditions, or to quantitatively measure the activated state of RelA by affinity binding.

US Patent:

20130214015, Aug 22, 2013

Filed:

Feb 19, 2013

Appl. No.:

13/770079

Inventors:

Thomas Wood - Huntington Beach CA, US
Eric Ferraro - Fountain Valley CA, US
Michelle Wood - Huntington Beach CA, US

International Classification:

A47G 25/14

US Classification:

223 85

Abstract:

A security device for supporting and immobilizing a garment is disclosed, where the device includes a flexible member that is capable of looping through a sleeve, trunk, or leg of the garment, and of looping through a stable object such as a fence. The flexible member, which can be a cable, includes a coupling member, and/or locking mechanism is made of plastic and used for wetsuits, inter alia.

US Patent:

57862133, Jul 28, 1998

Filed:

Apr 18, 1996

Appl. No.:

8/634546

Inventors:

Pomila Singh - Galveston TX
Thomas G. Wood - Houston TX

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C12N 500

US Classification:

4353201

Abstract:

The present invention discloses is for the treatment of colon cancer. The expression of gastrin by colon cancers is inhibited by the use of antisense gastrin expression. Methods are disclosed for the preparation of expression constructs and the use of such constructs to inhibit colon cancer growth.

Address:

16310 Harvest Summer Ct, Houston, TX 77059

VIN:

1NXBR32E07Z882908

Make:

TOYOTA

Model:

COROLLA

Year:

2007