Tianling O Chen

US Patent:

8008330, Aug 30, 2011

Filed:

Aug 28, 2009

Appl. No.:

12/549947

Inventors:

TianLing Chen - Florham Park NJ, US
Diane Greeley - Watchung NJ, US
John David Rothermel - Sunset Beach NC, US
Markus Wartmann - Riehen, CH
Jeanette Marjorie Wood - Biel-Benken, CH

Assignee:

Novartis AG - Basel

International Classification:

A61K 31/427
A61K 31/28

US Classification:

514365, 514492

Abstract:

The invention relates to a combination which comprises (a) a bisphosphonate, a platinum compound or a vasculostatic compound and (b) an epothilone derivative of formula I.

US Patent:

20040092478, May 13, 2004

Filed:

Sep 15, 2003

Appl. No.:

10/471904

Inventors:

John Rothermel - Randolph NJ, US
Horst Schran - Morristown NJ, US
Diane Greeley - Watchung NJ, US
TianLing Chen - Florham Park NJ, US

International Classification:

A61K031/485
A61K031/427
A61K031/454

US Classification:

514/054000, 514/282000, 514/365000, 514/503000, 514/323000

Abstract:

Epothilone derivatives are co-administered with an antidiarrheal agent, e.g., a DPP-IV inhibitor, in the treatment of a proliferative disease.

US Patent:

20040235796, Nov 25, 2004

Filed:

Jul 9, 2004

Appl. No.:

10/484482

Inventors:

TianLing Chen - Florham Park NJ, US
Diane Greeley - Watchung NJ, US
John Rothermel - Randolph NJ, US
Markus Wartmann - Riehen, CH
Jeanette Wood - Biel-Benken, CH

International Classification:

A61K033/24
A61K031/66
A61K031/427

US Classification:

514/102000, 514/365000, 424/649000

Abstract:

The invention relates to a combination which comprises (a) a bisphosphonate, a platinum compound or a vasculostatic compound and (b) an epothilone derivative of formula (I), wherein A represents O or NRN, wherein RN is hydrogen or lower alkyl, R is hydrogen or lower alkyl, and Z is O or a bond, in which the active ingredients (a) and (b) are present in each case in free form or in the form of a pharmaceutically acceptable salt and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the delay of progression or treatment of a proliferative disease, especially a solid tumor disease; a pharmaceutical composition, a commercial package or product comprising such a combination; the use of such a combination for the preparation of a medicament for the delay of progression or treatment of a proliferative disease and to a method of treatment of a warm-blooded animal.

US Patent:

20080119529, May 22, 2008

Filed:

Jan 24, 2008

Appl. No.:

12/019294

Inventors:

TianLing Chen - Florham Park NJ, US
Diane Greeley - Watchung NJ, US
John Rothermel - Sunset Beach NC, US
Markus Wartmann - Riehen, CH
Jeanette Wood - Biel-Benken, CH

International Classification:

A61K 31/426
A61P 43/00
C07D 417/06

US Classification:

514365000, 548204000

Abstract:

The invention relates to a combination which comprises (a) a bisphosphonate, a platinum compound or a vasculostatic compound and (b) an epothilone derivative of formula I wherein A represents O or NR, wherein Ris hydrogen or lower alkyl, R is hydrogen or lower alkyl, and Z is O or a bond, in which the active ingredients (a) and (b) are present in each case in free form or in the form of a pharmaceutically acceptable salt and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the delay of progression or treatment of a proliferative disease, especially a solid tumor disease; a pharmaceutical composition, a commercial package or product comprising such a combination; the use of such a combination for the preparation of a medicament for the delay of progression or treatment of a proliferative disease and to a method of treatment of a warm-blooded animal.