Tianyuan M Zhang from 3 Wendy Ct, Edison, NJ 08820, age 56

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Education:

Tianjin University of Finance and Economics

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Location:

Edison, NJ

Industry:

Pharmaceuticals

Work:

Merck
Senior Chemist

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Thienopyridones As Ampk Activators For The Treatment Of Diabetes And Obesity
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US Patent:

20050038068, Feb 17, 2005
Filed:

May 17, 2004
Appl. No.:

10/847144
Inventors:

Rajesh Iyengar - Lindenhurst IL, US
Andrew Judd - Grayslake IL, US
Gang Zhao - Northbrook IL, US
Philip Kym - Libertyville IL, US
Hing Sham - Vernon Hills IL, US
Yugui Gu - Libertyville IL, US
Gang Liu - Gurnee IL, US
Mei Liu - Gurnee IL, US
Hongyu Zhao - Buffalo Grove IL, US
Richard Clark - Gurnee IL, US
Ernst Frevert - Deerfield IL, US
Barbara Cool - Highland Park IL, US
Tianyuan Zhang - Gurnee IL, US
Robert Keyes - Pleasant Prairie WI, US
Todd Hansen - Grayslake IL, US
Zhili Xin - Lake Bluff IL, US
International Classification:

C07D498/02
A61K031/4743
US Classification:

514301000, 546114000
Abstract:

The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.

Novel Acetyl-Coa Carboxylase (Acc) Inhibitors And Their Use In Diabetes, Obesity And Metabolic Syndrome
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US Patent:

20060178400, Aug 10, 2006
Filed:

Nov 7, 2005
Appl. No.:

11/268698
Inventors:

Bruce Beutel - Lake Forest IL, US
Heidi Camp - Winnetka IL, US
Richard Clark - Gurnee IL, US
Todd Hansen - Grayslake IL, US
Robert Keyes - Pleasant Prairie WI, US
Qun Li - Libertyville IL, US
Gang Liu - Libertyville IL, US
Hing Sham - Vernon Hills IL, US
Xiaojun Wang - Libertyville IL, US
Moshe Weitzberg - Highland Park IL, US
Zhili Xin - Lake Bluff IL, US
Xiangdong Xu - Buffalo Grove IL, US
Tianyuan Zhang - Gurnee IL, US
International Classification:

C07D 211/68
A61K 31/445
US Classification:

514317000, 514340000, 546194000, 546268100
Abstract:

The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.

Thienopyridones As Ampk Activators For The Treatment Of Diabetes And Obesity
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US Patent:

20060287356, Dec 21, 2006
Filed:

Aug 24, 2006
Appl. No.:

11/509383
Inventors:

Rajesh Iyengar - Lindenhurst IL, US
Andrew Judd - Grayslake IL, US
Gang Zhao - Northbrook IL, US
Philip Kym - Libertyville IL, US
Hing Sham - Vernon Hills IL, US
Yugui Gu - Libertyville IL, US
Gang Liu - Gurnee IL, US
Mei Liu - Gurnee IL, US
Hongyu Zhao - Buffalo Grove IL, US
Richard Clark - Gurnee IL, US
Ernst Frevert - Deerfield IL, US
Barbara Cool - Highland Park IL, US
Tianyuan Zhang - Gurnee IL, US
Robert Keyes - Pleasant Prairie WI, US
Todd Hansen - Grayslake IL, US
Zhili Xin - Lake Bluff IL, US
International Classification:

C07D 498/02
A61K 31/4743
US Classification:

514301000, 546114000
Abstract:

The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.

Novel Acetyl-Coa Carboxylase (Acc) Inhibitors And Their Use In Diabetes, Obesity And Metabolic Syndrome
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US Patent:

20070225332, Sep 27, 2007
Filed:

Feb 15, 2007
Appl. No.:

11/675410
Inventors:

Yu Gui Gu - Libertyville IL, US
Moshe Weitzberg - Highland Park IL, US
Xiangdong Xu - Buffalo Grove IL, US
Richard Clark - Gurnee IL, US
Tianyuan Zhang - Gurnee IL, US
Qun Li - Libertyville IL, US
Todd Hansen - Grayslake IL, US
Hing Sham - South San Francisco CA, US
Bruce Beutel - Lake Forest IL, US
Heidi Camp - Winnetka IL, US
Xiaojun Wang - Libertyville IL, US
International Classification:

A61K 31/444
A61K 31/4439
A61K 31/433
A61K 31/427
A61K 31/42
C07D 417/14
C07D 413/02
US Classification:

514332000, 514365000, 514378000, 514362000, 514341000, 546256000, 546269700, 546268700, 548134000, 548202000, 548235000
Abstract:

The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.

Compounds Useful For Altering The Levels Of Bile Acids For The Treatment Of Diabetes And Cardiometabolc Disease
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US Patent:

20190218224, Jul 18, 2019
Filed:

Aug 10, 2017
Appl. No.:

16/324604
Inventors:

- Rahway NJ, US
Mary Ann Caplen - Sayreville NJ, US
Jared N. Cumming - Garwood NJ, US
Kevin D. Dykstra - West Milford NJ, US
Alan Hruza - Hackettstown NJ, US
Claire Lankin - High Bridge NJ, US
Derun Li - Scotch Plains NJ, US
Hong Liu - Hillsborough NJ, US
Amy McCracken - Berkeley Heights NJ, US
Brian McKittrick - New Vernon NJ, US
Ashwin Rao - Morganville NH, US
Jayaram Tagat - Westfield NJ, US
Haiqun Tang - Belle Mead NJ, US
Brandon M. Taoka - Hoboken NJ, US
Andreas Verras - New York NY, US
Shawn P. Walsh - Bridgewater NJ, US
Tianyuan Zhang - Edison NJ, US
Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:

C07D 487/04
C07D 519/00
C07D 498/04
Abstract:

Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for diabetes and cardiovascular disease.