Timothy J Eberlein

Address:

4909 Laclede Ave APT 2302, Saint Louis, MO 63108

Phone:

3144543005

VIN:

JNKAY01F77M453355

Make:

INFINITI

Model:

M35

Year:

2007

US Patent:

55502148, Aug 27, 1996

Filed:

Feb 10, 1994

Appl. No.:

8/195075

Inventors:

Timothy J. Eberlein - Dover MA
George E. Peoples - Newtonville MA
Ichiro Yoshino - Brookline MA
Peter Goedegebuure - Brighton MA

Assignee:

Brigham and Women's Hospital - Boston MA

International Classification:

A61K 3808
C07K 412

US Classification:

530328

Abstract:

An isolated antigenic peptide fragment that is an isolated oncogene protein fragment is disclosed. The isolated peptide fragment of the invention is a peptide either 9 or 10 amino acid residues in length that includes at least a leucine residue at the C- terminus (i. e. , position 9 or position 10). The peptide fragment is capable of binding in an HLA-A2 binding cleft and is capable of stimulating proliferation of at least one tumor-specific cytotoxic T-lymphocyte. Preferred peptides further include an isoleucine residue at position 2 and a valine residue at position 6. The most preferred isolated peptides can stimulate proliferation of cytotoxic T-lymphocytes obtainable from peripheral blood lymphocytes, ovarian tumors, breast tumors, gastric tumors, non-small cell lung tumors, pancreatic tumors, colon tumors, gliomas, bladder tumors, endometrial tumors and neuroblastomas. The preferred isolated peptide of the invention is a mutant peptide defined by SEQ ID NO. :2 or its functional equivalents.