Timothy David Fitzpatrick

US Patent:

55020356, Mar 26, 1996

Filed:

Jul 27, 1994

Appl. No.:

8/279677

Inventors:

Fortuna Haviv - Deerfield IL
Timothy D. Fitzpatrick - Boulder CO
Rolf E. Swenson - Grayslake IL
Charles J. Nichols - Greendale WI
Nicholas A. Mort - Waukegan IL

Assignee:

Tap Holdings Inc. - Abbott Park IL

International Classification:

C07K 1459

US Classification:

514 15

Abstract:

Decapaptide and undecapaptides substituted on the N-terminal nitrogen atom by acyl groups which include furo-2-yl, isonicotinyl, nicotinyl, 2-, 3-, and 4-quinolinecarbonyl, shikimyl, dihydroshikimyl, and tetrahydrofur-2-oyl are potent antagonists of LHRH and are useful for suppressing the levels of sex hormones in mammals.

US Patent:

54322634, Jul 11, 1995

Filed:

Jan 28, 1994

Appl. No.:

8/188293

Inventors:

Fortuna Haviv - Deerfield IL
Rolf E. Swenson - Grayslake IL
Timothy D. Fitzpatrick - Boulder CO

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3800

US Classification:

530345

Abstract:

The present invention provides a process for the preparation of peptides which have or side-chains containing an alkyl- or dialkyl-substituted guanidinyl group or a imidazinylamino or tetrahydropyrimidinylamino group. The process provides higher overall yields of peptide product by permitting the synthesis of the entire peptide chain prior to modification of the side-chain to introduce the groups.

US Patent:

51400090, Aug 18, 1992

Filed:

Jul 10, 1990

Appl. No.:

7/548511

Inventors:

Fortuna Haviv - Deerfield IL
Jonathan Greer - Chicago IL
Christopher A. Palabrica - River Hills WI
Timothy D. Fitzpatrick - Libertyville IL

Assignee:

Tap Pharmaceuticals, Inc. - Deerfield IL

International Classification:

C07K 706
C07K 720
A61K 3738

US Classification:

514 16

Abstract:

The present invention relates to novel LHRH analogs. The LHRH analogs include "pseudo" hexapeptide, heptapeptide, octapeptide and nonapeptide analogs of LHRH, wherein all or some of the amino acids, 1, 2 and 3 have been eliminated and the remaining (2-9), (2-10), (3-9), (3-10), (4-9) or (4-10) peptide is linked to various carboxylic acids which take the place of amino acids 1, 2 or 3 in LHRH.

US Patent:

56985223, Dec 16, 1997

Filed:

Jun 1, 1995

Appl. No.:

8/446809

Inventors:

Fortuna Haviv - Deerfield IL
Timothy D. Fitzpatrick - Salem OR
Rolf E. Swenson - Grayslake IL
Charles J. Nichols - Greendale WI
Nicholas A. Mort - Waukegan IL
Jonathan Greer - Chicago IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3809
C07K 723

US Classification:

514 15

Abstract:

The present invention provides a class of decapeptide compounds which are potent antagonists of LHRH activity and which have the structure A. sup. 1 -D. sup. 2 -E. sup. 3 -G. sup. 4 -J. sup. 5 -L. sup. 6 -M. sup. 7 -Q. sup. 8 -R. sup. 9 -T. sup. 10. The compounds of the percent invention are characterized by having an. OMEGA. -amino-functionalized side chain on the D-aminoacyl residue at position 6. The. OMEGA. -amino group of this side chain is further derivatized by the attachment of an extending group which likewise has a terminal amino group which is capped by an acyl group.

US Patent:

54139902, May 9, 1995

Filed:

Aug 6, 1993

Appl. No.:

8/103022

Inventors:

Fortuna Haviv - Deerfield IL
Timothy D. Fitzpatrick - Boulder CO
Rolf E. Swenson - Grayslake IL
Charles J. Nichols - Greendale WI
Nicholas A. Mort - Waukegan IL

Assignee:

Tap Pharmaceuticals Inc. - Deerfield IL

International Classification:

A61K 3700
A61K 3702
C07K 500
C07K 700

US Classification:

514 15

Abstract:

Decapaptides substituted on the N-terminal nitrogen atom by acyl groups are potent antagonists of LHRH and are useful for suppressing the levels of sex hormones in mammals.

US Patent:

57007799, Dec 23, 1997

Filed:

Jun 20, 1996

Appl. No.:

8/668100

Inventors:

Val S. Goodfellow - Westminster CO
Manoj V. Marathe - Pittsburgh PA
Eric T. Whalley - Golden CO
Timothy D. Fitzpatrick - Boulder CO
Karen G. Kuhlman - Denver CO

Assignee:

Cortech, Inc. - Denver CO

International Classification:

C07K 718

US Classification:

514 14

Abstract:

The present invention provides bradykinin type peptides containing N-substituted glycines, particularly bradykinin antagonist peptides useful for the treatment of conditions mediated by bradykinin including pain and inflammation.

US Patent:

20200002316, Jan 2, 2020

Filed:

Sep 13, 2019

Appl. No.:

16/570191

Inventors:

- Summit NJ, US
Timothy D. FITZPATRICK - Kirkland WA, US
Anthony FRANK - Easton PA, US
Ying LI - Millburn NJ, US
Xiaoling LU - Whippany NJ, US
Marie G. BEAUCHAMPS - Randolph NJ, US
Antonio C. FERRETTI - Summit NJ, US

International Classification:

C07D 403/10
A61P 35/00

Abstract:

Provided herein are compositions including the crystalline forms of (1E, 4E)-2-amino-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide (“Compound A”), methods of making the crystalline forms, and methods of using the crystalline forms for the treatment of diseases, including, for example, cancer.

US Patent:

20190100512, Apr 4, 2019

Filed:

Dec 15, 2015

Appl. No.:

15/537331

Inventors:

- Summit NJ, US
Timothy D. FITZPATRICK - Kirkland WA, US
Anthony FRANK - Easton PA, US
Ying LI - Millburn NJ, US
Xiaoling LU - Whippany NJ, US
Marie G. BEAUCHAMPS - Randolph NJ, US
Antonio C. FERRETTI - Summit NJ, US

Assignee:

Celgene Corporation - Summit NJ

International Classification:

C07D 403/10
A61P 35/00

Abstract:

Provided herein are compositions including the crystalline forms of (1E, 4E)-2-amino-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b] azepine-4-carboxamide (“Compound A”), methods of making the crystalline forms, and methods of using the crystalline forms for the treatment of diseases, including, for example, cancer.