Timothy A Hayes

US Patent:

20090258834, Oct 15, 2009

Filed:

May 24, 2007

Appl. No.:

11/802730

Inventors:

David J. Hammond - Laytonsville MD, US
Julia Tait Lathrop - Falls Church VA, US
Annemarie Ralston - Bethesda MD, US
Timothy K. Hayes - N. Potomac MD, US
Iwona Fijalkowska - Rockville MD, US

Assignee:

The American National Red Cross - Falls Church VA

International Classification:

A61K 38/06
G01N 33/573
C12N 9/14
G01N 33/566
C07K 7/06
A61K 38/08
C07K 5/08
C07K 14/435
C07K 14/75
C07K 14/575

US Classification:

514 17, 435 78, 435195, 436501, 514 18, 530329, 530330, 530331, 530359, 530382, 530383

Abstract:

The invention provides an isolated or purified peptide that binds at least one plasma protein. In one embodiment, the isolated or purified peptide binds to fibrinogen, comprises no more than 10 amino acids, and comprises an amino acid sequence Xaa-Xaa-Xaa-Xaa-Xaa, an amino acid sequence Gly-Xaa-Arg-Xaa, or an amino acid sequence selected from specific amino acid sequences provided herein. Alternatively, the isolated or purified protein binds to α1 proteinase inhibitor and/or a protein complex comprising Apo-A1 lipoprotein and paraoxonase. The peptide comprises no more than 10 amino acids and comprises an amino acid sequence Xaa-Xaa-Xaa-His-Xaa-Xaa, and amino acid sequence His-Xaa-Xaa-Xaa-Xaa-Xaa, or an amino acid sequence selected from specific amino acid sequences provided herein. In addition, the invention provides isolated or purified peptide that binds to von Willebrand Factor. The peptide comprises an amino acid sequence Xaa-Xaa-Xaa, an amino acid sequence Tyr-Leu-Xaa-Xaa-Xaa-Thr, or an amino acid sequence selected from specific amino acid sequences provided herein.