Timothy J Lewis

US Patent:

6451801, Sep 17, 2002

Filed:

Mar 24, 2000

Appl. No.:

09/534947

Inventors:

Ralph Scannell - Hopkinson MA
Pierre Chatelain - Pierre, BE
Anna Toy-Palmer - Arlington MA
Edmond Differding - Louvain-La-Neuve, BE
James Ellis - Boxford MA
Marie-Agnes Lassoie - Brainele-Chateau, BE
Xiong Cai - Belmont MA
Sajjat Hussoin - Lexington MA
Gurmit Grewal - Natick MA
Timothy Lewis - Framingham MA

Assignee:

UCB, S.A. - Brussels

International Classification:

A61K 31495

US Classification:

51425303, 5142541, 51425504, 514290, 514318, 514325, 514326, 514331, 544361, 544379, 544380, 544396, 546 93, 546203, 546231, 546234

Abstract:

The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl peperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferable asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

US Patent:

6686502, Feb 3, 2004

Filed:

Mar 11, 2003

Appl. No.:

10/386226

Inventors:

Xiong Cai - Belmont MA
Timothy Lewis - Marlborough MA

Assignee:

UCB S.A. - Brussels

International Classification:

C07C25904

US Classification:

562623, 564 58

Abstract:

The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted,4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

US Patent:

6797713, Sep 28, 2004

Filed:

Sep 12, 2002

Appl. No.:

10/242346

Inventors:

Ralph Scannell - Hopkinson MA
Pierre Chatelain - Woluwe Saint Pierre, BE
Anna Toy-Palmer - Arlington MA
Edmond Differding - Louvain-la-Neuve, BE
James Ellis - Boxford MA
Marie-Agnes Lassoie - Braine-le-Chateau, BE
Michelle Young - Belmont MA
Xiong Cai - Belmont MA
Sajjat Hussoin - Lexington MA
Gurmit Grewal - Natick MA
Timothy Lewis - Marlborough MA

Assignee:

UCB S.A. - Brussels

International Classification:

A61K 31495

US Classification:

51425504, 544396

Abstract:

The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

US Patent:

6894059, May 17, 2005

Filed:

Mar 23, 2000

Appl. No.:

09/937667

Inventors:

Ralph Scannell - Hopkinson MA, US
Pierre Chatelain - Woluwe Saint Pierre, BE
Anna Toy-Palmer - Arlington MA, US
Edmund Differding - Louvain-La-Neuve, BE
James Ellis - Boxford MA, US
Marie-Agnes Lassoie - Braine-Le-Chateau, BE
Michelle Young - Belmont MA, US
Xiong Cai - Belmont MA, US
Sajjat Hussoin - Lexington MA, US
Gurmit Grewal - Natick MA, US
Timothy Lewis - Framingham MA, US

Assignee:

UCB S.A. - Brussels

International Classification:

A61K031/44
A61K031/445

US Classification:

514290, 514325, 514329, 514330, 514331, 514340, 546 93, 546192, 546226, 546229, 5462681

Abstract:

The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obsructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

US Patent:

7778920, Aug 17, 2010

Filed:

Feb 25, 2002

Appl. No.:

10/082171

Inventors:

Marjorie Faith Zarin - New York NY, US
Rachel Glim - New York NY, US
Heather D. Kay - Hoboken NJ, US
Timothy Patrick Lewis - Phoenix AZ, US
Rhene Meyer - Phoenix AZ, US
Dafna Sarnoff - New York NY, US
Robert P. Cichon - Peoria AZ, US

Assignee:

American Express Travel Related Services Company, Inc. - New York NY

International Classification:

G06Q 40/00

US Classification:

705 38, 705 39

Abstract:

A system and method for providing in real-time an immediately accessible customized transaction account via the internet is disclosed. In particular, the system and method recognizes distinct access codes which are correlated to the credit profile of a person accessing an on-line application system via a computer network. During operation of the invention, a party may be driven to the on-line application system via the internet to conduct a transaction in response to an invitation to enroll in a special program. Upon entering the on-line application system, the accessing party may be unilaterally given the opportunity to apply for a special offer, which has been tailored to the accessing party's credit profile.

US Patent:

7930244, Apr 19, 2011

Filed:

Jul 6, 2010

Appl. No.:

12/831067

Inventors:

Marjorie Faith Zarin - New York NY, US
Rachel Glim - New York NY, US
Heather D. Kay - Hoboken NJ, US
Timothy Patrick Lewis - Phoenix AZ, US
Rhene Meyer - Phoenix AZ, US
Dafna Sarnoff - New York NY, US
Robert P. Cichon - Peoria AZ, US

Assignee:

American Express Travel Related Services Company, Inc. - New York NY

International Classification:

G06Q 40/00

US Classification:

705 38, 705 39

Abstract:

A system and method for providing in real-time an immediately accessible customized transaction account via the internet is disclosed. In particular, the system and method recognizes distinct access codes which are correlated to the credit profile of a person accessing an on-line application system via a computer network. During operation of the invention, a party may be driven to the on-line application system via the internet to conduct a transaction in response to an invitation to enroll in a special program. Upon entering the on-line application system, the accessing party may be unilaterally given the opportunity to apply for a special offer, which has been tailored to the accessing party's credit profile.

US Patent:

20040048875, Mar 11, 2004

Filed:

Aug 8, 2003

Appl. No.:

10/637163

Inventors:

Ralph Scannell - Hopkinson MA, US
Pierre Chatelain - Woluwe Saint Pierre, BE
Anna Toy-Palmer - Arlington MA, US
Edmond Differding - Louvain-La-Neuve, BE
James Ellis - Boxford MA, US
Marie-Agnes Lassoie - Braine-Le-Chateau, BE
Michelle Young - Belmont MA, US
Xiong Cai - Belmont MA, US
Sajjat Hussoin - Lexington MA, US
Gurmit Grewal - Natick MA, US
Timothy Lewis - Marlborough MA, US

Assignee:

UCB S.A.

International Classification:

A61K031/496
A61K031/495
A61K031/473
A61K031/4545

US Classification:

514/253010, 514/253030, 514/255040, 514/290000, 514/317000, 514/316000, 544/360000, 544/361000, 546/093000

Abstract:

The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted,4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

US Patent:

20100093716, Apr 15, 2010

Filed:

Aug 29, 2007

Appl. No.:

12/438793

Inventors:

Barbara A. Gilchrest - Boston MA, US
Mark S. Eller - Boston MA, US
Angela N. Koehler - Cambridge MA, US
Olivia M. McPherson - Cambridge MA, US
Christopher S. Neumann - Cambridge MA, US
Timothy A. Lewis - Marlborough MA, US

Assignee:

TRUSTEES OF BOSTON UNIVERSITY AND PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Boston MA

International Classification:

A61K 31/5386
C07D 498/20
A61P 35/04

US Classification:

5142295, 544 70

Abstract:

The present invention provides, inter alia, compositions and methods for treating various diseases and disorders in a mammal by administering to a mammal in need an effective amount of a composition comprising a non-DNA small molecule that binds WRN, such as members of the spirooxindole (SPOX) class.