Timothy J Lewis

US Patent:

6451801, Sep 17, 2002

Filed:

Mar 24, 2000

Appl. No.:

09/534947

Inventors:

Ralph Scannell - Hopkinson MA
Pierre Chatelain - Pierre, BE
Anna Toy-Palmer - Arlington MA
Edmond Differding - Louvain-La-Neuve, BE
James Ellis - Boxford MA
Marie-Agnes Lassoie - Brainele-Chateau, BE
Xiong Cai - Belmont MA
Sajjat Hussoin - Lexington MA
Gurmit Grewal - Natick MA
Timothy Lewis - Framingham MA

Assignee:

UCB, S.A. - Brussels

International Classification:

A61K 31495

US Classification:

51425303, 5142541, 51425504, 514290, 514318, 514325, 514326, 514331, 544361, 544379, 544380, 544396, 546 93, 546203, 546231, 546234

Abstract:

The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl peperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferable asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

US Patent:

6686502, Feb 3, 2004

Filed:

Mar 11, 2003

Appl. No.:

10/386226

Inventors:

Xiong Cai - Belmont MA
Timothy Lewis - Marlborough MA

Assignee:

UCB S.A. - Brussels

International Classification:

C07C25904

US Classification:

562623, 564 58

Abstract:

The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted,4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

US Patent:

6797713, Sep 28, 2004

Filed:

Sep 12, 2002

Appl. No.:

10/242346

Inventors:

Ralph Scannell - Hopkinson MA
Pierre Chatelain - Woluwe Saint Pierre, BE
Anna Toy-Palmer - Arlington MA
Edmond Differding - Louvain-la-Neuve, BE
James Ellis - Boxford MA
Marie-Agnes Lassoie - Braine-le-Chateau, BE
Michelle Young - Belmont MA
Xiong Cai - Belmont MA
Sajjat Hussoin - Lexington MA
Gurmit Grewal - Natick MA
Timothy Lewis - Marlborough MA

Assignee:

UCB S.A. - Brussels

International Classification:

A61K 31495

US Classification:

51425504, 544396

Abstract:

The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

US Patent:

6894059, May 17, 2005

Filed:

Mar 23, 2000

Appl. No.:

09/937667

Inventors:

Ralph Scannell - Hopkinson MA, US
Pierre Chatelain - Woluwe Saint Pierre, BE
Anna Toy-Palmer - Arlington MA, US
Edmund Differding - Louvain-La-Neuve, BE
James Ellis - Boxford MA, US
Marie-Agnes Lassoie - Braine-Le-Chateau, BE
Michelle Young - Belmont MA, US
Xiong Cai - Belmont MA, US
Sajjat Hussoin - Lexington MA, US
Gurmit Grewal - Natick MA, US
Timothy Lewis - Framingham MA, US

Assignee:

UCB S.A. - Brussels

International Classification:

A61K031/44
A61K031/445

US Classification:

514290, 514325, 514329, 514330, 514331, 514340, 546 93, 546192, 546226, 546229, 5462681

Abstract:

The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obsructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

US Patent:

20040048875, Mar 11, 2004

Filed:

Aug 8, 2003

Appl. No.:

10/637163

Inventors:

Ralph Scannell - Hopkinson MA, US
Pierre Chatelain - Woluwe Saint Pierre, BE
Anna Toy-Palmer - Arlington MA, US
Edmond Differding - Louvain-La-Neuve, BE
James Ellis - Boxford MA, US
Marie-Agnes Lassoie - Braine-Le-Chateau, BE
Michelle Young - Belmont MA, US
Xiong Cai - Belmont MA, US
Sajjat Hussoin - Lexington MA, US
Gurmit Grewal - Natick MA, US
Timothy Lewis - Marlborough MA, US

Assignee:

UCB S.A.

International Classification:

A61K031/496
A61K031/495
A61K031/473
A61K031/4545

US Classification:

514/253010, 514/253030, 514/255040, 514/290000, 514/317000, 514/316000, 544/360000, 544/361000, 546/093000

Abstract:

The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted,4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

US Patent:

20100093716, Apr 15, 2010

Filed:

Aug 29, 2007

Appl. No.:

12/438793

Inventors:

Barbara A. Gilchrest - Boston MA, US
Mark S. Eller - Boston MA, US
Angela N. Koehler - Cambridge MA, US
Olivia M. McPherson - Cambridge MA, US
Christopher S. Neumann - Cambridge MA, US
Timothy A. Lewis - Marlborough MA, US

Assignee:

TRUSTEES OF BOSTON UNIVERSITY AND PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Boston MA

International Classification:

A61K 31/5386
C07D 498/20
A61P 35/04

US Classification:

5142295, 544 70

Abstract:

The present invention provides, inter alia, compositions and methods for treating various diseases and disorders in a mammal by administering to a mammal in need an effective amount of a composition comprising a non-DNA small molecule that binds WRN, such as members of the spirooxindole (SPOX) class.

US Patent:

20230017200, Jan 19, 2023

Filed:

Jul 11, 2022

Appl. No.:

17/862255

Inventors:

- Leverkusen, DE
- Berlin, DE
- Cambridge MA, US
- Boston MA, US
Adrian TERSTEEGEN - Wuppertal, DE
Philip LIENAU - Berlin, DE
Christa HEGELE-HARTUNG - Mülheim an der Ruhr, DE
Detlev SÜLZLE - Berlin, DE
Timothy A. LEWIS - Cambridge MA, US
Heidi GREULICH - Cambridge MA, US
Xiaoyun WU - Cambridge MA, US
Matthew MEYERSON - Boston MA, US
Alex BURGIN - Cambridge MA, US

Assignee:

Bayer Aktiengesellschaft - Leverkusen
Bayer Pharma Aktiengesellschaft - Berlin
The Broad Institute, Inc. - Cambridge MA
Dana-Farber Cancer Institute, Inc. - Boston MA

International Classification:

C07D 273/04
C07D 413/10
C07D 413/12
C07D 417/10
C07D 471/04
C07D 491/107
C07D 495/10

Abstract:

The present invention provides dihydrooxydiazinone compounds of general formula (I):in which R, R, R, and R, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.

US Patent:

20210353630, Nov 18, 2021

Filed:

Jul 30, 2021

Appl. No.:

17/389940

Inventors:

- Leverkusen, DE
- Cambridge MA, US
Philip LIENAU - Berlin, DE
Charlotte Christine KOPITZ - Falkensee, DE
Martin LANGE - Berlin, DE
Adrian TERSTEEGEN - Wuppertal, DE
Detlev SÜLZLE - Berlin, DE
Timothy A. LEWIS - Cambridge MA, US
Heidi GREULICH - Cambridge MA, US
Xiaoyun WU - Cambridge MA, US

Assignee:

BAYER AKTIENGESELLSCHAFT - Leverkusen
THE BROAD INSTITUTE, INC. - Cambridge MA

International Classification:

A61K 31/53
A61P 35/00
C07D 403/10
C07D 403/12
C07D 253/06

Abstract:

The present invention includes name compounds of general formula (I): (I) in which R, R, Rand Rare as defined herein, methods for their preparation, pharmaceutical compositions and combinations comprising said compounds, and their use for the treatment of hyperproliferative diseases.