Timothy J Lewis

US Patent:

6451801, Sep 17, 2002

Filed:

Mar 24, 2000

Appl. No.:

09/534947

Inventors:

Ralph Scannell - Hopkinson MA
Pierre Chatelain - Pierre, BE
Anna Toy-Palmer - Arlington MA
Edmond Differding - Louvain-La-Neuve, BE
James Ellis - Boxford MA
Marie-Agnes Lassoie - Brainele-Chateau, BE
Xiong Cai - Belmont MA
Sajjat Hussoin - Lexington MA
Gurmit Grewal - Natick MA
Timothy Lewis - Framingham MA

Assignee:

UCB, S.A. - Brussels

International Classification:

A61K 31495

US Classification:

51425303, 5142541, 51425504, 514290, 514318, 514325, 514326, 514331, 544361, 544379, 544380, 544396, 546 93, 546203, 546231, 546234

Abstract:

The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl peperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferable asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

US Patent:

6686502, Feb 3, 2004

Filed:

Mar 11, 2003

Appl. No.:

10/386226

Inventors:

Xiong Cai - Belmont MA
Timothy Lewis - Marlborough MA

Assignee:

UCB S.A. - Brussels

International Classification:

C07C25904

US Classification:

562623, 564 58

Abstract:

The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted,4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

US Patent:

6797713, Sep 28, 2004

Filed:

Sep 12, 2002

Appl. No.:

10/242346

Inventors:

Ralph Scannell - Hopkinson MA
Pierre Chatelain - Woluwe Saint Pierre, BE
Anna Toy-Palmer - Arlington MA
Edmond Differding - Louvain-la-Neuve, BE
James Ellis - Boxford MA
Marie-Agnes Lassoie - Braine-le-Chateau, BE
Michelle Young - Belmont MA
Xiong Cai - Belmont MA
Sajjat Hussoin - Lexington MA
Gurmit Grewal - Natick MA
Timothy Lewis - Marlborough MA

Assignee:

UCB S.A. - Brussels

International Classification:

A61K 31495

US Classification:

51425504, 544396

Abstract:

The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

US Patent:

6894059, May 17, 2005

Filed:

Mar 23, 2000

Appl. No.:

09/937667

Inventors:

Ralph Scannell - Hopkinson MA, US
Pierre Chatelain - Woluwe Saint Pierre, BE
Anna Toy-Palmer - Arlington MA, US
Edmund Differding - Louvain-La-Neuve, BE
James Ellis - Boxford MA, US
Marie-Agnes Lassoie - Braine-Le-Chateau, BE
Michelle Young - Belmont MA, US
Xiong Cai - Belmont MA, US
Sajjat Hussoin - Lexington MA, US
Gurmit Grewal - Natick MA, US
Timothy Lewis - Framingham MA, US

Assignee:

UCB S.A. - Brussels

International Classification:

A61K031/44
A61K031/445

US Classification:

514290, 514325, 514329, 514330, 514331, 514340, 546 93, 546192, 546226, 546229, 5462681

Abstract:

The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obsructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

US Patent:

6920566, Jul 19, 2005

Filed:

Jul 12, 2002

Appl. No.:

10/194857

Inventors:

Timothy A. Lewis - El Dorado Hills CA, US

Assignee:

Phoenix Technologies Ltd. - Milpitas CA

International Classification:

G06F012/14

US Classification:

713194, 713193, 711163

Abstract:

Systems, methods and software that use a programmable lock bit that disables read access to a firmware ROM until the CPU is reset or enters into a secure CPU mode. The present invention provides for secure system firmware by preventing access to and reading of the contents of the firmware ROM.

US Patent:

7043729, May 9, 2006

Filed:

Aug 8, 2002

Appl. No.:

10/214909

Inventors:

Timothy A. Lewis - El Dorado Hills CA, US

Assignee:

Phoenix Technologies Ltd. - Milpitas CA

International Classification:

G06F 9/46

US Classification:

718103, 718107, 718108, 712244, 712245, 710260, 710261, 710262, 710263, 710264, 710265, 710266, 710267, 710268, 710269

Abstract:

Systems, methods, and software for reducing system management interrupt (SMI) latency while operating in system management mode. The present invention implements a technique for exiting system management mode while waiting for polled hardware events, handling any pending lower-priority interrupts and then resuming polling. The present invention does this by multi-threading SMI source handlers, using an idle thread, and using protocols for software-generated system management interrupts that insure that lower priority interrupts are serviced.

US Patent:

7917762, Mar 29, 2011

Filed:

Sep 28, 2006

Appl. No.:

11/529140

Inventors:

Timothy Andrew Lewis - El Dorado Hills CA, US
Timothy Joseph Markey - San Jose CA, US

Assignee:

Phoenix Technologies Ltd. - Milpitas CA

International Classification:

H04L 9/32

US Classification:

713176, 726 4, 726 10, 705 54, 713180

Abstract:

A device and method for providing a secure execution environment includes retrieving a boot loader, for example, from the memory of an electronic device or from a peripheral component. Next, a determination is made as to whether the boot loader is authorized to be executed on the corresponding electronic device. If the boot loader is authorized, then the boot loader code is executed. By only allowing execution of authorized boot loaders, security related breaches are substantially reduced or eliminated; thereby, enhancing device integrity.

US Patent:

7949874, May 24, 2011

Filed:

Sep 28, 2006

Appl. No.:

11/529141

Inventors:

Timothy Andrew Lewis - El Dorado Hills CA, US
Timothy Joseph Markey - San Jose CA, US

Assignee:

Phoenix Technologies Ltd. - Milpitas CA

International Classification:

G06F 21/00

US Classification:

713170, 713 2, 710 1, 710 62

Abstract:

A method for providing a secure firmware operating environment includes detecting the presence of a new component, for example, a peripheral device. Next, a determination is made as to whether the peripheral device includes an option read-only memory. Next, a determination is made as to whether the option read-only memory is authorized to be executed on the corresponding device. If the option read-only memory is authorized, the code contained within the option read-only memory is executed. By only allowing execution of peripheral devices or components including authorized option read-only memories, security related breaches are substantially reduced or eliminated; thereby, enhancing device integrity.