Timothy Lee Patrick

US Patent:

6413204, Jul 2, 2002

Filed:

Apr 15, 1999

Appl. No.:

09/293524

Inventors:

Rance A. Winkler - Atlanta GA
Timothy J. Patrick - Alpharetta GA
James Stubbs - Alpharetta GA

Assignee:

Proxima Therapeutics, Inc. - Alpharetta GA

International Classification:

A61N 500

US Classification:

600 3

Abstract:

An interstitial brachytherapy apparatus for delivering radioactive emissions to an internal body location includes a catheter body member having a proximal end and distal end, an inner spatial volume disposed proximate to the distal end of the catheter body member, an outer spatial volume defined by an expandable surface element disposed proximate to the distal end of the body member in a surrounding relation to the inner spatial volume, and a radiation source disposed in the inner spatial volume.

US Patent:

6482142, Nov 19, 2002

Filed:

Dec 16, 1999

Appl. No.:

09/464727

Inventors:

Rance A. Winkler - Atlanta GA
Timothy J. Patrick - Alpharetta GA

Assignee:

Proxima Therapeutics, Inc. - Alpharetta GA

International Classification:

A61N 500

US Classification:

600 3

Abstract:

An interstitial brachytherapy apparatus of the invention delivers radioactive emissions in an asymmetric fashion to target tissue surrounding a surgical extraction site. The apparatus includes an expandable outer surface element defining an apparatus spatial volume, a radiation source disposed within the apparatus volume, and a means for providing predetermined asymmetric isodose curves within the target tissue. In one configuration, asymmetric isodose curves are created in the target tissue by shaping or locating the radiation source so as to be asymmetrically placed with respect to a longitudinal axis of the apparatus. In other configurations, asymmetric radiopaque shielding is provided between the radiation source and the target tissue. A surgical procedure using the apparatus is also described.

US Patent:

6695760, Feb 24, 2004

Filed:

Oct 11, 2002

Appl. No.:

10/269555

Inventors:

Rance A. Winkler - Atlanta GA
Timothy J. Patrick - Alpharetta GA
Carribeth B. Ramey - Suwanee GA

Assignee:

Proxima Therapeutics - Alpharetta GA

International Classification:

A61N 500

US Classification:

600 7, 623 1716, 606192

Abstract:

A radiotherapy system, and preferably a brachytherapy system, for delivering radiation to tissue surrounding an interstitial space is provided. While the system can be used for a variety of purposes, the system is preferably used to treat spinal metastases. In general, the system includes a catheter member having a proximal end, a distal end, and an inner lumen extending therethrough, and a structural support adapted to fit within an interstitial space in load bearing portion of a patients body and having an internal space for removably receiving the distal end of the catheter member. At least one anchoring element can be disposed proximate to the distal end of the catheter. The anchoring element is preferably adapted to fit within the internal space in the structural support so as to anchor the distal end of the catheter therein. The system further includes a radiation source disposable within the internal space of the structural support through the lumen in the catheter for delivering radiation to tissue surrounding the interstitial space.

US Patent:

6749555, Jun 15, 2004

Filed:

Feb 13, 2003

Appl. No.:

10/365977

Inventors:

Rance A. Winkler - Atlanta GA
Timothy J. Patrick - Alpharetta GA
Carribeth B. Ramey - Suwanee GA

Assignee:

Proxima Therapeutics, Inc. - Alpharetta GA

International Classification:

A61N 500

US Classification:

600 3

Abstract:

A brachytherapy system for treating metastases on and around a patients spinous process is provided. The device generally includes a catheter member having a proximal portion, a distal portion, and at least one lumen extending therethrough. The distal portion of the catheter member includes first and second branch members that are adapted to be positioned on opposed sides of a patients spinous process. The device further includes first and second elongate anchoring elements disposed on the first and second branch members, and optionally can include at least one centering mechanism disposed within each of the first and second anchoring elements. The first and second anchoring elements are preferably adapted to be positioned between a spinous process and transverse process of at least one vertebral body, and to extend along a length of a patients spinal column, such that the first and second anchoring elements, when expanded, engage and anchor the first and second branch members between the spinous process and transverse process of at least one vertebral body.

US Patent:

6976949, Dec 20, 2005

Filed:

Feb 20, 2004

Appl. No.:

10/784083

Inventors:

Rance A. Winkler - Atlanta GA, US
Timothy J. Patrick - Alpharetta GA, US
Carribeth B. Ramey - Suwanee GA, US

Assignee:

Proxima Therapeutics, Inc. - Alpharetta GA

International Classification:

A61N005/00
A61F002/44
A61M029/00

US Classification:

600 7, 623 1716, 606192

Abstract:

A radiotherapy system, and preferably a brachytherapy system, for delivering radiation to tissue surrounding an interstitial space is provided. While the system can be used for a variety of purposes, the system is preferably used to treat spinal metastases. In general, the system includes a catheter member having a proximal end, a distal end, and an inner lumen extending therethrough, and a structural support adapted to fit within an interstitial space in load bearing portion of a patient's body and having an internal space for removably receiving the distal end of the catheter member. At least one anchoring element can be disposed proximate to the distal end of the catheter. The anchoring element is preferably adapted to fit within the internal space in the structural support so as to anchor the distal end of the catheter therein. The system further includes a radiation source disposable within the internal space of the structural support through the lumen in the catheter for delivering radiation to tissue surrounding the interstitial space.

US Patent:

7494457, Feb 24, 2009

Filed:

Nov 7, 2003

Appl. No.:

10/704344

Inventors:

Rance A. Winkler - Atlanta GA, US
Bartolome J. Salazar - Alpharetta GA, US
Timothy J. Patrick - Alpharetta GA, US
James B. Stubbs - Alpharetta GA, US

Assignee:

CYTYC Corporation - Marlborough MA

International Classification:

A61M 36/00

US Classification:

600 7

Abstract:

A brachytherapy device is provided for treating a target tissue through an external surface area of the target tissue. The device includes an insertion member having a proximal portion, a distal portion, and at least one lumen extending therethrough. A fluid retaining member is mated to the distal portion of the insertion member and has a first surface shaped to conform to a predetermined external surface area of a tissue to be treated, and a cavity formed therein in fluid communication with the at least one lumen in the insertion member. A plurality of anchor members can be distributed about a periphery of the first surface to anchor the first surface to an external surface area of a tissue to be treated.

US Patent:

7524274, Apr 28, 2009

Filed:

Nov 7, 2003

Appl. No.:

10/704161

Inventors:

Timothy J. Patrick - Alpharetta GA, US
James B. Stubbs - Alpharetta GA, US

Assignee:

Cytyc Corporation - Marlborough MA

International Classification:

A61N 5/00

US Classification:

600 1

Abstract:

A system for treating tissue surrounding a resected cavity that is subject to a proliferative tissue disorder is provided. The system includes a tissue fixation device including a catheter body member having a proximal end, a distal end, an inner lumen, and an expandable surface element disposed proximate to the distal end of the body member, the expandable surface element sized and configured to reproducibly position tissue surrounding a resected tissue cavity in a predetermined geometry upon expansion. After expansion of the expandable surface element within a resected tissue cavity, an external radiation device positioned outside the resected cavity delivers a dose of radiation to the tissue surrounding the expandable surface element.

US Patent:

7524275, Apr 28, 2009

Filed:

Nov 14, 2003

Appl. No.:

10/714586

Inventors:

Timothy J. Patrick - Alpharetta GA, US
James B. Stubbs - Alpharetta GA, US

Assignee:

Cytyc Corporation - Marlborough MA

International Classification:

A61N 5/00

US Classification:

600 2, 600 3

Abstract:

An interstitial brachytherapy apparatus and methods for treating proliferative tissue disorders with radiation and a surface delivered treatment agent. The brachytherapy device includes an insertion member having proximal and distal portions and at least one lumen extending therethrough. An expandable surface member is mated to the distal portion of the insertion member and includes a treatment agent releasably mated thereon. When the brachytherapy device is positioned within a tissue cavity and the expandable surface member is expanded, at least a portion of the treatment agent is delivered to tissue surrounding the tissue cavity.